Griseofulvin |
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Last updated: 29/01/2025
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(Also known as: grisovin; delmofulvina; grisefuline; (+)-griseofulvin) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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Natural substance to treat fungal infections of the skin and nails |
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Athletes foot, Ringworm |
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Humans; Livestock; Domestic animals |
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- |
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Considered obsolete but may be available in some countries |
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1939, first reported |
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Not approved |
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Not applicable |
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No UK approval for use as a pesticide |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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Griseofulvin is a chiral molecule. Substance is racemic. |
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C₁₇H₁₇ClO₆ |
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CC1CC(=O)C=C(C12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC |
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C[C@@H]1CC(=O)C=C([C@]12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC |
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DDUHZTYCFQRHIY-RBHXEPJQSA-N |
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InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1 |
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Yes |
Cambridge Crystallographic Data Centre diagrams |
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Common Name |
Relationship |
Link |
griseofulvin |
Unstated isomer |
 |
griseofulvin |
- |
 |
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Fungicide, Veterinary substance |
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Benzofuran fungicide |
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97% |
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- |
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Natural |
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Acts by binding to keratin in keratin precursor cells making them resistant to fungal infections. |
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126-07-8 |
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204-767-4 |
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308 |
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471400 |
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441140 |
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No data found |
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352.77 |
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- |
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(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro [1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione |
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7-chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1'-(2'-methoxy-6'-methylcyclohex-2'-en-4'-one) |
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- |
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- |
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Not applicable |
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Not applicable |
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Not applicable |
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Not applicable |
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- |
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White to pale cream-coloured, odourless crystalline powder |
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- |
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- Obsolete - not thought to be commercially available for crop protection applications
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Was available in a variety of formulations including oral powders, pastes and granules for top dressing use |
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8.64 |
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Low |
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- |
- |
- |
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218 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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570 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
- |
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210 |
sublimes |
- |
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228 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
- |
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2.29 X 1002 |
Calculated |
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2.36 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Low |
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- |
- |
- |
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- |
- |
- |
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1.43 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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- |
- |
- |
- |
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1.28 X 10-03 |
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Low volatility |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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Max 286nm and 325nm |
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- |
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- |
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- |
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- |
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- |
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- |
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- |
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- |
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- |
- |
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- |
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- |
- |
- |
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- |
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- |
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- |
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- |
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- |
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- |
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- |
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- |
- |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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- |
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Cannot be calculated |
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- |
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- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
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Known soil and groundwater metabolites |
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None
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6-dimethylgriseofulvin |
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Mammals (Urine) |
- |
Terrestrial ecotoxicology |
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> 10000 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source Rat |
Low |
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- |
- |
- |
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- |
- |
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> 1000 |
R4 R = Peer reviewed scientific publications 4 = Verified data Daphnia magna |
Low |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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> 10000 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source Rat |
Low |
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- |
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- |
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Intraperitoneal LD₅₀ > 5000 mg kg⁻¹ |
Rat |
- |
Subcutaneous LD₅₀ > 12000 mg kg⁻¹ |
Mouse |
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EU MRL pesticide database |
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Excreted mainly in the urine and faeces. Deposited in varying concentrations in the keratin layer of the skin, hair, and nails |
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- |
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Carcinogen |
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Endocrine disruptor |
?Possibly, status not identified |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E1 E = Unspecified genotoxicity type (miscellaneous data source) 1 = Positive |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
?Possibly, status not identified |
No data found |
✓Yes, known to cause a problem |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
✓Yes, known to cause a problem |
✓Yes, known to cause a problem |
No data found |
Eye irritant |
Phototoxicant |
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✓Yes, known to cause a problem |
✓Yes, known to cause a problem |
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IARC Group 2B carcinogen; CLP data - suspected carcinogen May cause nausea, diarrhoea, hives, hives and fatigue Possible blood and liver toxicant |
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When heated to decomposition it emits toxic fumes of halogen gases |
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Health: H317, H351, H360 Environment: H411 |
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Not classified: Obsolete (Not classified: Obsolete) |
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griseofulvin |
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griseofulvine |
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griseofulvina |
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Record last updated: |
29/01/2025 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |