Bronopol |
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Last updated: 14/11/2024
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(Also known as: bronocot; bronidiol) |
Bronopol is a fungicide and bactericide used mainly for non-food/feed purposes. It is highly soluble in water and is not considered volatile. It is moderately toxic to most fauna and flora. It is also moderately toxic if ingested and is a recognised irritant. |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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A bactericide used mainly for non-food/feed purposes. Also has applications in fish medicine. |
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Broad spectrum of microbials; Slime; Moulds |
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Non-agricultual applications such as air conditioning systems, humidifying systems, water colling, industrial processes |
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- |
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Current |
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1971 reported; 1984 first registered USA |
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Not approved |
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Expired |
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No UK approval for use as a pesticide |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Expired |
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- |
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Yes |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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None |
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C₃H₆BrNO₄ |
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C(C(CO)([N+](=O)[O-])Br)O |
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No data |
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LVDKZNITIUWNER-UHFFFAOYSA |
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InChI=1S/C3H6BrNO4/c4-3(1-6,2-7)5(8)9/h6-7H,1-2H2 |
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Yes |
Cambridge Crystallographic Data Centre diagrams |
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Common Name |
Relationship |
Link |
bronopol |
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 |
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Fungicide, Veterinary substance, Other substance |
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Preservative, Biocide, Disinfectant, Algicide |
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Unclassified pesticide |
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- |
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- |
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Synthetic |
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Inhibition of dehydrogenase activity causes membrane damage |
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52-51-7 |
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200-143-0 |
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None allocated |
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216400 |
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2450 |
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603-085-00-8 |
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200.0 |
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2-bromo-2-nitropropane-1,3-diol |
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2-bromo-2-nitropropane-1,3-diol |
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2-bromo-2-nitro-1,3-propanediol |
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Listed on USA Toxic Release Inventory; PAN Bad Actor Chemical |
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- |
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Not applicable |
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Not applicable |
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Not applicable |
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7 |
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- |
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Colourless to pale yellow/brown solid |
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- Dow Chemical Co
- Rohm and Haas
- Bayer CropScience
- FBC
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- Onyxide 500
- Bronotak
- Brolly
- Bronocot
- Bugstick
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Usually supplied as a powder for dry application to seeds or as a liquid concentrate for use with fish |
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250000 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
High |
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500000 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Ethanol |
- |
250000 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Isopropanol |
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10000 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Glycerol |
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130 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Decomposes before boiling |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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- |
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1.51 X 1000 |
Calculated |
- |
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0.18 |
P3 P = Other non-EU, UK or US Governments and Regulators 3 = Unverified data of known source |
Low |
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- |
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- |
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- |
- |
- |
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- |
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- |
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- |
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1.68 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Low volatility. If applied directly to plants or soil, drift is a concern & mitigation is advisable |
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1.16 X 10-06 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Non-volatile |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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Very mobile |
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5.0 |
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Estimated |
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Cannot be calculated |
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0.28 |
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source Estimated |
Low potential |
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Not available |
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Known groundwater metabolites |
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None
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2-hydroxy-2-nitropropane-1,3-diol (tris) |
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2-hydroxymethyl-2-nitropropane-1,3-diol(tris) |
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Water (Hydrolysis) |
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2-bromo-2-nitroethanol |
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Terrestrial ecotoxicology |
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254 |
Rat |
Moderate |
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L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Rat |
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1000 |
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> 510 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Anas platyrhynchos |
Moderate |
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> 20 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Oncorhynchus mykiss |
Moderate |
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1.94 |
Oncorhynchus mykiss 49 day |
Moderate |
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> 1.4 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Daphnia magna |
Moderate |
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> 5.9 |
Americamysis bahia |
Moderate |
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> 0.52 |
Crassostrea gigas Embryo |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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254 |
Rat |
Moderate |
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1600 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Rat |
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5.0 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Rat |
- |
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Intraperitoneal LD₅₀ = 26.0 mg kg⁻¹ |
Rat |
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Intravenous LD₅₀ = 37.4 mg kg⁻¹ |
Rat |
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0.02 |
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EU MRL pesticide database |
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Metabolism studies indicate that bronopol is primarily excreted in the urine. |
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Carcinogen |
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Endocrine disruptor |
XNo, known not to cause a problem |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
XNo, known not to cause a problem |
XNo, known not to cause a problem |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
✓Yes, known to cause a problem |
✓Yes, known to cause a problem |
No data found |
Eye irritant |
Phototoxicant |
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✓Yes, known to cause a problem |
No data found |
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May cause contact dermatitis May cause stomach lesions |
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Prevent release of dust Not expected to auto-ignite; Not highly flammable |
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Health: H302, H312, H315, H318, H335 Environment: H400 |
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II (Moderately hazardous) |
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bronopol |
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bronopol |
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Bronopol |
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bronopol |
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bronopolum |
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bronopol |
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bronopol |
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bronoplu |
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bronopol |
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bronopol |
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bronopol |
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Record last updated: |
14/11/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |