L-ascorbic acid |
Last updated: 31/10/2024 |
(Also known as: Vitamin C; ascorbic acid; 3-oxo-1-gulofuranolactone) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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Substance with fungicide and bactericide action against a range of crop diseases | |
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Phytophthora infestans; fusarium spp.; botrytis spp. | |
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Potatoes; Tomatoes; Ornamentals | |
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- | |
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- | |
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Current | |
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18th Centuary, discovered; 2011, introduced as pesticide | |
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UK regulatory status |
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Not approved | ||
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Withdrawn | ||
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Netherlands | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information |
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Chemical structure |
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Ascorbic acid exists as two enantiomers commonly referred to as L-ascorbic acide and D-ascorbic acid. The L-isomer is the more common. | |
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C₆H₈O₆ | |
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C(C(C1C(=C(C(=O)O1)O)O)O)O | |
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C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O | |
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CIWBSHSKHKDKBQ-JLAZNSOCSA-N | |
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InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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L-ascorbic acid | - | |
L-ascorbic acid | - |
General status |
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Fungicide, Other substance | |
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Bactericide, Biocide | |
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Plant-derived substance | |
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>990 g kg⁻¹ | |
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EU dossier - methanol <3g kg⁻¹; heavy metals 0.01g kg⁻¹ | |
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Natural | |
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Systemic, protective, stimulates the natural defence mechanisms and wound healing processes in plants | |
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A naturally occurring substance that can be isolated from synergistic vitamin C complexes found in living nutrient sources particularly citrus fruits, tomatoes and tomato juice, and potatoes | |
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Manufactered for commercial use from corn or refined sugar | |
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Crop protection | |
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Phytophthora infestans; fusarium spp.; botrytis spp. | |
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Potatoes; Tomatoes; Ornamentals | |
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- | |
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50-81-7 | |
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200-066-2 | |
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774 | |
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- | |
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- | |
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176.1 | |
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- | |
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(5R)-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one | |
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- | |
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Some applications may be approevd under the GB Biocide Products Regulations | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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NC | |
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White powder |
Formulations |
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Usually supplied as a soluble liquid |
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330000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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Insoluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Ether5 = Verified data used for regulatory purposes |
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Insoluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Benzene5 = Verified data used for regulatory purposes |
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Insoluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Chloroform5 = Verified data used for regulatory purposes |
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50000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Propylene glycol5 = Verified data used for regulatory purposes |
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190 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Decomposes before boiling | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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190 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1.32 X 10-02 | Calculated | - | |||||||
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-1.88 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low | ||||||||
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2.19 X 10-02 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility | ||||||||
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1.16 X 10-08 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-volatile | ||||||||
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pH 6.4: max @ 265nm pH 2: max @ 245nm |
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Not surface active | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Degradation |
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15 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 3 = Unverified data of known source |
Fast | ||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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ascorbate-2-sulphate | - | Human | - | ||||
oxalic acid | - | Human | - | ||||
dehydroascorbic acid | - | Human | - |
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Terrestrial ecotoxicology |
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11900 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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> 250 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Gallus domesticus NOEL3 = Unverified data of known source |
Moderate | ||||||||
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> 1000 | Q2 Q = Miscellaneous data from online sources Expert judgement2 = Unverified data of unknown source |
Low | ||||||||
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> 4.5 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Apis mellifera3 = Unverified data of known source |
Moderate | |||||||
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> 15.9 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Apis mellifera3 = Unverified data of known source |
Moderate | ||||||||
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> 0.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Aphidius rhopalosiphi5 = Verified data used for regulatory purposes |
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9.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Typhlodromus pyri5 = Verified data used for regulatory purposes |
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> 17 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Poecilus cupreus5 = Verified data used for regulatory purposes |
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Aquatic ecotoxicology |
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> 2000 | Q2 Q = Miscellaneous data from online sources Unknown species2 = Unverified data of unknown source |
Low | ||||||||
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2000 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oreochromis niloticus 3 = Unverified data of known source |
Low | ||||||||
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General |
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Low (class I) | - | - | ||||||||
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11900 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Intravenous LD₅₀ = 518 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 10000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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None allocated | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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None allocated | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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None allocated | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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100 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Considered safe | |||||||||
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Considered safe | ||||||||||
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Readily absorbed and excreted mainly in the urine in humans and via the lungs in rats and guinea pigs | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Excessive consumption may cause diarrhoea and behavioural effects |
Handling issues |
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Not explosive or oxidising Not expected to auto-ignite; Not highly flammable |
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Health: H315, H318, H319 | |||
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Not listed (Not listed) | |||
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Not regulated | |||
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L-ascorbic acid | ||
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acide ascorbique | ||
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acidum ascorbicum | ||
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acido ascorbico | ||
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Record last updated: | 31/10/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |