Pyrethrins (cinerin I) |
Last updated: 31/10/2024 |
(Also known as: pyrethum; cinerin) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A non-persistent insecticide extracted from Pyrethrum used to control a variety of pests on crops, in domestic and public health situations | |
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A wide range of insects and mites | |
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Vegetables; Fruit; Protected crops; Ornamentals; Public areas | |
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- | |
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- | |
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Current | |
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circa 1930, introduced | |
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- |
UK regulatory status |
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Approved | ||
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31/08/2026 | ||
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None |
EC Regulation 1107/2009 (repealing 91/414) |
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Approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Italy/Germany | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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15/06/2026 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information |
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USA, East Africa, Australia |
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Chemical structure |
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Cinerin-I is a complex molecule with three chiral centres. | |
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C₂₀H₂₈O₃ | |
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CC=CCC1=C(C(CC1=O)OC(=O)C2C(C2(C)C)C=C(C)C)C | |
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C/C=C\CC1=C([C@@H](CC1=O)OC(=O)[C@@H]2[C@H](C2(C)C)C=C(C)C)C | |
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FMTFEIJHMMQUJI-RWRPJIPASA-N | |
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InChI=1S/C20H28O3/c1-7-8-9-14-13(4)17(11-16(14)21)23-19(22)18-15(10-12(2)3)20(18,5)6/h7-8,10,15,17-18H,9,11H2,1-6H3/b8-7-/t15-,17-,18+/m1/s1 | |
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Yes |
General status |
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Insecticide, Acaricide, Veterinary substance | |
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Plant-derived substance | |
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- | |
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- | |
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Natural | |
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Contact acting neurotoxins with repellent properties. Sodium channel modulator. | |
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Originally isolated from the dried powdered flowers of the plant genus Chrysanthemum | |
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Extracted from the flowers of Tanacetum cineriaefolium | |
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Crop protection; Public health | |
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A wide range of insects and mites | |
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Vegetables; Fruit; Protected crops; Ornamentals; Public areas | |
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Suitable for use in all farming systems where approved for use in that country | |
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25402-06-6 | |
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8003-34-7 | |
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246-948-0 | |
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32 | |
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- | |
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- | |
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316.4 | |
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- | |
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(Z)-(S)-3-(but-2-enyl)-2-methyl-4-oxocyclopent-2-enyl(1R)-trans-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate | |
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(1R-(1α(S(Z),3β))-3-(2-butenyl)-2-methyl-4-oxo-2-cyclopenten-1-yl 2,2-dimethyl-3-(2-methyl-1-propenyl) cyclopropanecarboxylate | |
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- | |
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- | |
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Not applicable | |
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Not applicable | |
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3A | |
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Not applicable | |
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Blattella germanica, Boophilus decoloratus, Myzus persicae, Plodia interpunctella, Spodoptera litura, many others | |
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Viscous amber coloured liquid | |
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Formulations |
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Evergreen Crop Protetction 60-6 | MGK | ||||
Diatect II | Diatect International | |||||
Pyrethrum 5EC concentrate | Agropharm Ltd | |||||
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Available in a variety of formulations including ultra low-volume liquids and ready-to-use sprays for crop and public health applications and as powders, shampoos and impregnated collars for animals. |
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- | - | - | ||||||||
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250000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) n-Heptane5 = Verified data used for regulatory purposes |
- | ||||||||
250000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) p-Xylene5 = Verified data used for regulatory purposes |
- | |||||||||
250000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Methane5 = Verified data used for regulatory purposes |
- | |||||||||
250000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Acetone5 = Verified data used for regulatory purposes |
- | |||||||||
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- | - | - | ||||||||
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- | - | - | ||||||||
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190 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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- | - | - | ||||||||
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3.47 X 1005 | Calculated | - | |||||||
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5.54 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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- | - | - | |||||||
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- | - | - | ||||||||
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0.85 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
- | ||||||||
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Not applicable | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
No dissociation | |||||||||||
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6.93 X 10-02 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility | ||||||||
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- | - | - | ||||||||
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- | - | - | |||||||
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- | - | - | ||||||||
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- | - | - | ||||||||
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52.8 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as pyrethrins4 = Verified data |
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Degradation |
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- | ||||||||||
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2 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Non-persistent | |||||||
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2.5 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Non-persistent | ||||||||
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12 | H4 H = The US ARS pesticide properties database. Dataset is no longer available. 4 = Verified data |
Non-persistent | ||||||||
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6.3 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-persistent | ||||||||
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EU dossier lab studies for pyrethrins | ||||||||||
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3.6 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Peach fruit, n=1 | ||||||||||
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- | ||||||||||
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0.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Fast | |||||||
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Rapid | ||||||||||
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528 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Very persistent | |||||||
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- | ||||||||||
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3.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Fast | ||||||||
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1.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately fast | ||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | H3 H = The US ARS pesticide properties database. Dataset is no longer available. 3 = Unverified data of known source |
Non-mobile | |||||||
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100000 | ||||||||||
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Literature data | ||||||||||
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298 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-mobile | |||||||
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27019 | ||||||||||
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0.986 | ||||||||||
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EU dossier data for pyrethrins Kf range 198-430 mL g⁻¹, kfoc range 12472-74175 mL g⁻¹, 1/n range 0.907-1.10, Soils=4 | ||||||||||
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No |
Known soil metabolites |
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Minor fraction | 0.05 | - |
Known groundwater metabolites |
None
Other known metabolites |
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hydroxy-chrysanthenic acid | - | Plant | - | ||||
dihydroxy-chrysanthenic acid | - | Plant | - | ||||
dicarboxylic-chrysanthenic acid | - | Plant; Humans (Urine) | - | ||||
aldehyde-chrysanthenic acid | - | Plant | - |
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Terrestrial ecotoxicology |
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1050 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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- | - | - | |||||||
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- | - | |||||||||
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- | - | - | ||||||||
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> 51151 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Anas platyrhynchos as pyrethrins4 = Verified data |
Low | ||||||||
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- | - | - | ||||||||
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- | - | - | ||||||||
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23.7 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida corr4 = Verified data |
Moderate | ||||||||
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0.25 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida corr4 = Verified data |
Moderate | ||||||||
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- | - | - | ||||||||
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0.013 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Apis mellifera4 = Verified data |
High | |||||||
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0.10 | K3 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) Apis mellifera3 = Unverified data of known source |
High | ||||||||
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- | |||||||||||
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- | |||||||||||
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- | ||||||||||
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- | - | - | |||||||
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- | ||||||||||
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- | - | - | ||||||||
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- | - | - | ||||||||
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Harmful | Q2 Q = Miscellaneous data from online sources Parasitic wasp2 = Unverified data of unknown source |
- | ||||||||
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Harmless | AA2 AA = IOBC Database on classification of side effects to beneficial organisms, 2005 Typhlodromus pyri2 = Unverified data of unknown source |
- | ||||||||
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- | - | - |
Aquatic ecotoxicology |
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0.005 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Oncorhynchus mykiss as pyrethrins4 = Verified data |
High | ||||||||
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- | - | - | ||||||||
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- | - | - | ||||||||
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0.273 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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- | - | - | ||||||||
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- | - | - | ||||||||
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0.0014 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Americamysis bahia as pyrethrins4 = Verified data |
High | ||||||||
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- | - | - | ||||||||
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- | - | - | ||||||||
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320 | S1 S = Expert judgement Unknown species1 = Estimated data with little or no verification |
Low | ||||||||
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- | - | - |
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- | - | - |
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General |
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Intermediate (class II) | - | - | ||||||||
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1050 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat as Pyrethrins5 = Verified data used for regulatory purposes |
- | ||||||||
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3.4 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat as Pyrethrins5 = Verified data used for regulatory purposes |
- | ||||||||
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Intraperitoneal LD₅₀ = 200 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat Pyrethrins3 = Unverified data of known source |
- | ||||||||
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0.04 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
- | ||||||||
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0.2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
- | ||||||||
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- | - | - | ||||||||
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None allocated | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
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10 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) default5 = Verified data used for regulatory purposes |
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Almost completely excreted within 72hrs | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- |
Health issues |
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May cause dermatitis May cause gastointestinal problems Possible thyroid and liver toxicant |
Handling issues |
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Not explosive or oxidising Not expected to auto-ignite; Not highly flammable IMDG Transport Hazard Class 9 |
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Health: H332, H312, H302 Environment: H400, H410 |
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II (Moderately hazardous) | |||
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UN3082 | |||
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Packaging Group III (minor danger) | |||
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pyrethrins (cinerin I) | ||
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pyrethrines | ||
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Pyrethrine | ||
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pyrethrin | ||
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piretrine | ||
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piretrina | ||
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- | ||
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pyretryny | ||
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pyretriner | ||
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- | ||
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pyrethrinen | ||
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- |
Record last updated: | 31/10/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |