Sanguinarine |
Last updated: 27/05/2024
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(Also known as: Macleaya extract) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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A naturally occuring escharotic quarternary ammonium substance with acaricidal, fungicidal and insecticidal activity, usually used as the chloride salt |
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Powdery mildew; Texas root rot (Phymatotrichopsis omnivora); Blight; Honey fungus |
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Ornamentals including roses; Cotton |
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Current |
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Not approved |
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Not applicable |
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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C₂₀H₁₄NO₄ |
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C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6 |
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No data |
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INVGWHRKADIJHF-UHFFFAOYSA-N |
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InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1 |
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Yes |
Cambridge Crystallographic Data Centre diagrams |
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Common Name |
Relationship |
Link |
sanguinarine |
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Insecticide, Acaricide, Fungicide, Other substance |
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Antimicrobial |
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Plant-derived substance |
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Natural |
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Induces the release of membrane-bound cell wall autolytic enzymes, which eventually result in lysis of the cell |
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A substance extracted from a range of plants including bloodroot (Sanguinaria canadensis), pink plume poppy (Macleaya cordata,/i>) and the Mexican prickly poppy (Argemone mexicana) |
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Extracted from collected biomass |
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Crop protection |
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Powdery mildew; Texas root rot (Phymatotrichopsis omnivora); Blight; Honey fungus |
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Ornamentals including roses; Cotton |
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Suitable for use in all farming systems where approved for use in that country |
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2447-54-3 |
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332.36 |
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13-methyl(1,3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridin-13-ium |
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13-methyl(1,3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridin-13-ium |
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13-methyl(1,3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium |
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Not applicable |
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Not applicable |
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Not known |
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Not known |
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None identified |
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Orange-red coloured crystalline solid |
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266 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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1660 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Rat |
Moderate |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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1660 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Rat |
Moderate |
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2.2 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Rat |
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Subcutaneous LD₅₀ = 125 mg kg⁻¹ |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Rabbit |
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Intraperitoneal LD₅₀ = 18 mg kg⁻¹ |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Rat |
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Carcinogen |
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Endocrine disruptor |
XNo, known not to cause a problem |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
No data found |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
No data found |
No data found |
Eye irritant |
Phototoxicant |
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No data found |
No data found |
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Anti-inflammatory Some evidence to suggest it has anti-cancer properties Toxic if ingested |
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Corrosive |
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Not listed (Not listed) |
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sanguinarine |
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chlorure de sanguinarine |
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Record last updated: |
27/05/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |