Lepimectin |
![]() Last updated: 24/08/2025 |
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(Not known by any other names) |
Hazard alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate | Ecotoxicity | Human health |
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A novel natural insecticide for the control of sucking and biting insects | |
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Thrips; Mites; Moths; Leaf-miners | |
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Vegetables including onions, leeks, sweet potato, cauliflower, peppers, lettuce; Fruit including melon, apple, pear, peach; Ornamentals | |
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GB regulatory status |
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Not approved | ||
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Not applicable | ||
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No UK approval for use as a plant protection agent |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information |
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Japan |
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Chemical structure |
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Lepimectin has isomeric forms: Lepimectin A3 and Lepimectin A4 | |
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C₈₁H₁₀₄N₂O₂₀ | |
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Yes |
General status |
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Insecticide; Veterinary substance | |
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Milbemycin (mixture of ethyl & methyl derivatives) | |
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Natural | |
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Glutamate-gated chloride channel (GluCl) allosteric modulator. | |
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The milbemycins are products of fermentation by Streptomyces species | |
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Crop protection | |
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Thrips; Mites; Moths; Leaf-miners | |
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Vegetables including onions, leeks, sweet potato, cauliflower, peppers, lettuce; Fruit including melon, apple, pear, peach; Ornamentals | |
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171249-05-1 | |
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1425.69 | |
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mixture of 80 to 100% (2aE,4E,8E)-(5'S,6S,6'R,7R,11R,13R,15S,17aR,20R,20aR,20bS)-6'-ethyl-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-tetradecahydro-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxospiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2'-[2H]pyran]-7-yl (Z)-2-methoxyimino-2-phenylacetate and 20–0% (2aE,4E,8E)-(5'S,6S,6'R,7R,11R,13R,15S,17aR,20R,20aR,20bS)-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-tetradecahydro-20,20b-dihydroxy-5',6,6',8,19-pentamethyl-17-oxospiro(11,15-methano-2H13H,17H-furo(4,3,2-pq)(2,6)benzodioxacyclooctadecin-13,2'-(2H)pyran)-7-yl (Z)-2-methoxyimino-2-phenylacetate | |
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mixture of 80 to 100% (2aE,4E,8E)-(5'S,6S,6'R,7R,11R,13R,15S,17aR,20R,20aR,20bS)-6'-ethyl-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-tetradecahydro-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxospiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2'-[2H]pyran]-7-yl (Z)-2-methoxyimino-2-phenylacetate and 20–0% (2aE,4E,8E)-(5'S,6S,6'R,7R,11R,13R,15S,17aR,20R,20aR,20bS)-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-tetradecahydro-20,20b-dihydroxy-5',6,6',8,19-pentamethyl-17-oxospiro[11,15-methano-2H,13H,17H-furo(4,3,2-pq)(2,6)benzodioxacyclooctadecin-13,2'-(2H)pyran)-7-yl (Z)-2-methoxyimino-2-phenylacetate | |
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(6R,13R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-13-((Z)-((methoxyimino)phenylacetyl)oxy)-25-methylmilbemycin B mixture with (6R,13R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-ethyl-13-((Z)-((methoxyimino)phenylacetyl)oxy)milbemycin B | |
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Not applicable | |
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Not applicable | |
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Off-white coloured solid |
Commercial |
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Current | |||
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1972, first isolated | |||
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Usually formulated as an emulsifiable concentrate | |||
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Lepimectin is commercially produced through a semi-synthetic process that begins with fermentation of Streptomyces species to yield milbemycin derivatives, specifically 15-hydroxy-5-ketomilbemycin A3 and A4. These intermediates are then chemically modified by coupling with methoxyiminophenylacetic acid, followed by reduction using agents like sodium borohydride to produce lepimectin A3 and A4, the active components of the final product | |||
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Degradation |
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1.8 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Undercover grown shallot bulbs, n=1 | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2000 | Q2 Q = Miscellaneous data from online sources Rat2 = Unverified data of unknown source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 2000 | Q2 Q = Miscellaneous data from online sources Rat2 = Unverified data of unknown source |
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Health issues |
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No information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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lepimectin | ||
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lepimectine | ||
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Record last updated: | 24/08/2025 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |