1,2,4-trimethoxybenzene |
Last updated: 12/06/2024
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(Also known as: hydroxyhydroquinone trimethyl ether; pseudocumene) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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1,2,4-trimethoxybenzene occurs naturally in coal tar, petroleum and some plant oils. It can be used as a repellent for insects, cats and dogs |
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Insects including mosquitoes; Cats; Dogs |
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Non-food areas; Public places |
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Current |
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1994, first registered USA |
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Not approved |
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Not applicable |
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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Substance is one of 3 isomers of trimethylbenzene. |
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C₉H₁₂O₃ |
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COC1=CC(=C(C=C1)OC)OC |
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COC1=CC(=C(C=C1)OC)OC |
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AGIQIOSHSMJYJP-UHFFFAOYSA-N |
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InChI=1S/C9H12O3/c1-10-7-4-5-8(11-2)9(6-7)12-3/h4-6H,1-3H3 |
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Yes |
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Insecticide, Semiochemical |
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Methoxybenzene substance; Aromatic hydrocarbon substance; Petroleum derivative; Plant-derived substance |
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97% |
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- |
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Natural |
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Repellent |
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Substance occurs naturally in coal tar and petroleum at around 2-5%. It can also be found in some plants oils e.g. Rhizophora apiculata |
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Produced commercially from the C9 aromatic hydrocarbon fraction during petroleum distillation. It is also produced by the methylation of toluene and xylenes |
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General pest management |
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Insects including mosquitoes; Cats; Dogs |
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Non-food areas; Public places |
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- |
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135-77-3 |
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205-219-7 |
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67284 |
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168.19 |
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1,2,4-trimethoxybenzene |
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1,2,4-trimethoxybenzene |
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1,2,4-trimethoxybenzene |
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- |
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- |
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Not applicable |
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Not applicable |
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Not applicable |
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Not applicable |
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- |
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Pale yellow to yellow-brown coloured liquid with strong characteristic odour |
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20 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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247 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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77.9 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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5.13 X 1001 |
Calculated |
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1.71 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Low |
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1.128 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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Carcinogen |
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Endocrine disruptor |
XNo, known not to cause a problem |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative |
XNo, known not to cause a problem |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
No data found |
✓Yes, known to cause a problem |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
✓Yes, known to cause a problem |
✓Yes, known to cause a problem |
No data found |
Eye irritant |
Phototoxicant |
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✓Yes, known to cause a problem |
No data found |
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No information available |
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No information available |
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Health: H315, H319, H335 Environment: H411 |
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Not listed (Not listed) |
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Not regulated |
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1,2,4-trimethoxybenzene |
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Record last updated: |
12/06/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |