Ledprona (Ref: GS2) |
Last updated: 12/06/2024
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(Not known by any other names) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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A novel foliar-applied double-stranded RNA biopesticide that offers excellent control of Colorado beetle ((Leptinotarsa decemlineata)) where resistence exists against traditional pesticides |
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Colorado beetle ((Leptinotarsa decemlineata)) |
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Potatoes and other solanaceous vegetables |
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Extensive investigation has shown significant effectiveness against colarado beetle and exposure to Ledprona for 6 h results in larval mortality |
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Novel |
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Not approved |
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Not applicable |
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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None |
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C₄₄₀₉H₅₃₉₈N₁₇₉₄O₃₂₀₈P₄₆₀ (Sense); C₄₃₃₁H₅₃₈₅N₁₆₂₅O₃₂₃₄P₄₆₀ (Antisense) |
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YROCNOMGGCXEN-KVQQXCGEBA-N (Sense); JITAZDZERUFLGA-RJPZJKRDBA-N (Antisense) |
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Yes |
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Insecticide |
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RNA |
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Semi-synthetic |
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Ledprona prevents the production of Proteasome Subunit Beta Type-5 protein in the insect via RNA interference (RNAi) which causs the beetle to stop eating and expire from accumulation of its own metabolic waste |
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Manufactered using a novel, economically sound method of producing dsRNA |
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Commercial synthesis |
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Crop protection |
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Colorado beetle (,i>(Leptinotarsa decemlineata)) |
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Potatoes and other solanaceous vegetables |
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Suitable for use in all farming systems where approved for use in that country |
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2433753-68-3 |
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No data found |
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No data found |
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RNA (Leptinotarsa decemlineata-specific recombinant double-stranded interfering GS2) |
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Not applicable |
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Not applicable |
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35 |
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Not applicable |
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Not applicable |
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RNA |
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Calantha |
GreenLight |
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Foliar applied |
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3.0 |
P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data |
Non-persistent |
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As ledprona is based on double-stranded ribonucleic acid it will degrade quickly in the environment |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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Carcinogen |
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Endocrine disruptor |
No data found |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
No data found |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
No data found |
No data found |
Eye irritant |
Phototoxicant |
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No data found |
No data found |
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No significant health effects anticipated |
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No information available |
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Not listed (Not listed) |
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ledprona |
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ledprona |
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Record last updated: |
12/06/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |