Spider venom peptide |

Last updated: 17/09/2025
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(Also known as: spider knottin) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate |
Ecotoxicity |
Human health |
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Complex substances, derived from spider venom rich in chemicals such as disulfide-rich peptides which exhibit insecticidal activity |
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Cockroach; Helicoverpaarmigera; Spodoptera littoralis; Drosophila suzukii; Thrips; Whiteflies; Mites; Houseflies; Fruit flies; Armyworms, Coddling moth; Fruit moths; Fruitworms |
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Hemp; Tobacco; Field and greenhouse crops; Cannabis; Fruit including blueberries, berries, stone fruits, tree fruits; Nursery crops; Brassicas; Legumes; Leafy crops; Citrus; Ornamentals |
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Not approved |
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Not applicable |
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No UK approval for use as a plant protection agent |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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Not applicable |
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No |
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Insecticide; Miticide |
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Animal-derived substance; Peptide insecticide |
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Natural |
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Insect neurotoxin. Nicotinic acetylcholine receptor (nAChR) channel blocker site II |
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Substance is derived from the Australian funnel spider (Hadronyche versuta) |
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Crop protection |
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Cockroach; Helicoverpaarmigera; Spodoptera littoralis; Drosophila suzukii; Thrips; Whiteflies; Mites; Houseflies; Fruit flies; Armyworms, Coddling moth; Fruit moths; Fruitworms |
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Hemp; Tobacco; Field and greenhouse crops; Cannabis; Blueberries |
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Suitable for IPM where approved for use |
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2307677-15-0 |
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None allocated |
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None allocated |
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GS-omega/kappa HXTX-Hv1a peptide |
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Not applicable |
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Not applicable |
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32 |
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Not applicable |
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- |
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Brown liquid with yeast-like odour |
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Novel |
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Usually supplied as a liquid concentrate |
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It may be produced by fermentation but, currently, this is not commercially viable. It can be synthesised and optimized using the genes from the venom and incorporating these into yeast. |
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Ball park estimates for GHG emissions from peptide production suggest an order of magnitude in the range of 20–200+ kg CO₂e per kg of formulated peptide active, with wide uncertainty depending on route, scale, and solvent recovery. The lower end of the scale applies to bioprocess/fermentation routes, If the peptide is produced via recombinant expression and downstream processing is efficient and electrically powered with average grids, totals could plausibly sit in the tens of kg CO₂e/kg. The higher end of the scale applies to solid phase chemical synthesis which can be solvent and energy intensive. Without aggressive solvent recovery and at modest scales, totals can readily move into the high tens to low hundreds of kg CO₂e/kg, and higher if yields are low or purification is demanding. |
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1.03 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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> 5000 |
E4 E = Manufacturers safety data sheets 4 = Verified data Rat |
Low |
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> 100 |
R4 R = Peer reviewed scientific publications 4 = Verified data Apis mellifera |
Low |
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0.035 |
R4 R = Peer reviewed scientific publications 4 = Verified data Apis mellifera |
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HUMAN HEALTH AND PROTECTION |
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Not applicable |
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> 5000 |
E4 E = Manufacturers safety data sheets 4 = Verified data Rat |
Low |
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5000 |
E4 E = Manufacturers safety data sheets 4 = Verified data Rat |
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> 2.05 |
E4 E = Manufacturers safety data sheets 4 = Verified data Rat |
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Risk to residents and the general public is low when used in accordance with label instructions |
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Occupational risks are acceptable when used in accordance with label instructions |
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Carcinogen |
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Endocrine disruptor |
No data found |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
No data found |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
?Possibly, status not identified |
XNo, known not to cause a problem |
Eye irritant |
Phototoxicant |
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?Possibly, status not identified |
XNo, known not to cause a problem |
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No information available |
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No information available |
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Not listed (Not listed) |
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Not regulated |
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Store unopened at room temperature. Do not freeze. |
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Spider venom peptide |
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Record last updated: |
17/09/2025 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |