Spider venom peptide |
Last updated: 24/07/2024
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(Also known as: spider knottin) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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Complex substances, derived from spider venom rich in chemicals such as disulfide-rich peptides which exhibit insecticidal activity |
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Cockroach; Helicoverpaarmigera; Spodoptera littoralis; Drosophila suzukii; Thrips; Whiteflies; Mites; Houseflies; Fruit flies; Armyworms, Coddling moth; Fruit moths; Fruitworms |
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Hemp; Tobacco; Field and greenhouse crops; Cannabis; Fruit including blueberries, berries, stone fruits, tree fruits; Nursery crops; Brassicas; Legumes; Leafy crops; Citrus; Ornamentals |
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Novel |
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Not approved |
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Not applicable |
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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Insecticide, Miticide |
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Animal-derived substance; Peptide insecticide |
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Natural |
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Insect neurotoxin. Nicotinic acetylcholine receptor (nAChR) channel blocker site II |
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Substance is derived from the Australian funnel spider (Hadronyche versuta) |
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It may be produced by fermentation but, currently, this is not commcercially viable. It can be synthesized and optimized using the genes from the venom and incorporating these into yeast |
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Crop protection |
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Cockroach; Helicoverpaarmigera; Spodoptera littoralis; Drosophila suzukii; Thrips; Whiteflies; Mites; Houseflies; Fruit flies; Armyworms, Coddling moth; Fruit moths; Fruitworms |
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Hemp; Tobacco; Field and greenhouse crops; Cannabis; Blueberries |
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Suitable for IPM where approved for use |
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2307677-15-0 |
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None allocated |
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None allocated |
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GS-omega/kappa HXTX-Hv1a peptide |
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Not applicable |
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Not applicable |
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32 |
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Not applicable |
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- |
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Brown liquid with yeast-like odour |
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Spear-T |
Vestaron Corporation, USA |
Spear-LEP |
Vestaron Corporation, USA |
Spear-RC |
Vestaron Corporation, USA |
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Usually supplied as a liquid concentrate |
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1.03 |
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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> 5000 |
E4 E = Manufacturers safety data sheets 4 = Verified data Rat |
Low |
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> 100 |
R4 R = Peer reviewed scientific publications 4 = Verified data Apis mellifera |
Low |
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0.035 |
R4 R = Peer reviewed scientific publications 4 = Verified data Apis mellifera |
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HUMAN HEALTH AND PROTECTION |
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Not applicable |
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> 5000 |
E4 E = Manufacturers safety data sheets 4 = Verified data Rat |
Low |
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5000 |
E4 E = Manufacturers safety data sheets 4 = Verified data Rat |
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> 2.05 |
E4 E = Manufacturers safety data sheets 4 = Verified data Rat |
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Risk to residents and the general public is low when used in accordance with label instructions |
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Occupational risks are acceptable when used in accordance with label instructions |
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Carcinogen |
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Endocrine disruptor |
No data found |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
No data found |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
?Possibly, status not identified |
XNo, known not to cause a problem |
Eye irritant |
Phototoxicant |
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?Possibly, status not identified |
XNo, known not to cause a problem |
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No information available |
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No information available |
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Not listed (Not listed) |
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Not regulated |
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Store unopened at room temperature. Do not freeze. |
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Spider venom peptide |
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Record last updated: |
24/07/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |