Oxytetracycline |
Last updated: 31/07/2024 |
(Also known as: terramycin; oxytracyl; oxytetrin; terramitsin; oxitetracycline; crop antibiotic; liquamycin) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A bactericide, usually used as the hydrochloride, for the control of bacteria, fungi and mycoplasma-like organisms in fruit and turf. It is also used in veterinary products and for aquaculture | |
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Bacterial diseases including fireblight and those caused by Pseudomonas spp. and Xanthomonas spp. | |
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Top fruit; Stone fruit; Turf | |
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Current | |
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1974, first registered USA | |
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UK regulatory status |
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Not approved | ||
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Not applicable | ||
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Additional information |
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Chemical structure |
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A complex molecule with 6 chiral centres | |
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C₂₂H₂₄N₂O₉ | |
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CC1(C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O | |
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C[C@@]1([C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O | |
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IWVCMVBTMGNXQD-PXOLEDIWSA-N | |
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InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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oxytetracycline | - |
General status |
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Veterinary substance, Crop antibiotic, Other substance | |
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Antimicrobial | |
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Micro-organism derived substance | |
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Natural | |
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Broad spectrum, protein synthesis inhibitor and binds to the 30S and 50S bacterial ribosomal subunits | |
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Substance produced by the fermentation of Streptomyces rimosus | |
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Produced by controlled fermentation for commerical use and usually formulated as the hydrochloride salt | |
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Crop protection | |
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Bacterial diseases including fireblight and those caused by Pseudomonas spp. and Xanthomonas spp. | |
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Top fruit; Stone fruit; Turf | |
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79-57-2 | |
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2058-46-0; 6153-64-6 (dihydrate) | |
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201-212-8 | |
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316 | |
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006308 | |
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460.44 | |
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(4S,4aR,5S,5aR,6S,12aS)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide | |
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(4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide | |
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Possible groundwater contaminant | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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41 | |
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Pale yellow to tan coloured crystalline powder | |
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Formulations |
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Mycoshield | Syngenta | ||||
Phytomycin | Ladda | |||||
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Supplied as a water soluble powder for preparation as injection when used as a veterinary product. For crop protection it is used as a foliar spray |
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600 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
High | ||||||||
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Decomposes on melting | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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179 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Degradation |
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8.2 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Brussel sprouts undercover | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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7200 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
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> 5620 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Anas platyrhynchos as HCl variant3 = Unverified data of known source |
Low | ||||||||
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1954 | R3 R = Peer reviewed scientific publications as HCl variant3 = Unverified data of known source |
Low | ||||||||
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100 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) as HCl variant3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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116 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss as HCl variant3 = Unverified data of known source |
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102 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna as HCl variant3 = Unverified data of known source |
Low | ||||||||
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46.2 | R3 R = Peer reviewed scientific publications Daphnia magna as HCl variant3 = Unverified data of known source |
Low | ||||||||
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0.342 | R3 R = Peer reviewed scientific publications Selenastrum capricornutum as HCl variant3 = Unverified data of known source |
Moderate | ||||||||
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0.183 | R3 R = Peer reviewed scientific publications Selenastrum capricornutum as HCl variant3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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7200 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
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Systemically available oxytetracycline was primarily excreted in the urine and bile | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause hypersensitivity reactions May cause tooth discoloration |
Handling issues |
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No information available | |||
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Health: H302, H312, H317, H332, H360d Environment: H400, H410 |
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Not listed (Not listed) | |||
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oxytetracycline | ||
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oxytetracycline | ||
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Oxytetracyclin | ||
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oxytetracyclin | ||
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oxytetracicline | ||
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oxitetraciclina | ||
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oksytetracyklina | ||
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Record last updated: | 31/07/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |