Validamycin A |
Last updated: 07/06/2024
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(Also known as: validamycin; BBF-03433) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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An antibiotic with fungicide action effective against soil borne diseases and is used for the control of Rhizoctonia solani |
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Sheath blight disease caused by Rhizoctonia species |
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Rice; Potatoes; Vegetables; Soft fruit; Sugar beet; Cotton |
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- |
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- |
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Current |
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1972, registered Japan |
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Class: Validamycins |
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Not approved |
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Expired |
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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- |
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Expired |
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- |
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Yes |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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A chiral molecule |
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C₂₀H₃₅NO₁₃ |
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C1C(C(C(C(C1NC2C=C(C(C(C2O)O)O)CO)O)O)OC3C(C(C(C(O3)CO)O)O)O)CO |
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C1[C@@H]([C@H]([C@@H]([C@H]([C@H]1N[C@H]2C=C([C@H]([C@@H]([C@H]2O)O)O)CO)O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)CO |
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JARYYMUOCXVXNK-CSLFJTBJSA-N |
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InChI=1S/C20H35NO13/c22-3-6-1-8(12(26)15(29)11(6)25)21-9-2-7(4-23)19(17(31)13(9)27)34-20-18(32)16(30)14(28)10(5-24)33-20/h1,7-32H,2-5H2/t7-,8+,9+,10-,11-,12+,13+,14-,15+,16+,17-,18-,19-,20+/m1/s1 |
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Yes |
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Fungicide, Antibiotic |
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Micro-organism derived substance |
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[Typically >95%] |
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- |
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Natural |
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Non-systemic, inhibits the enzyme trehalase, an important enzyme in carbohydrate storage and ultilisation in fungi. |
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Originally isolated from the soil actinomycete Streptomyces hygroscopicus |
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Produced for commerical purposes by controlled fermentation |
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Crop protection |
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Sheath blight disease caused by Rhizoctonia species |
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Rice; Potatoes; Vegetables; Soft fruit; Sugar beet; Cotton |
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- |
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37248-47-8 |
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- |
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8353 |
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- |
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443629 |
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497.49 |
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- |
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(2R,3R,4S,5S,6R)-2-[(1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol |
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1,5,6-trideoxy-4-O-β-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-D-chiro-inositol |
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PAN listed Highly Hazardous Chemical |
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- |
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Not applicable |
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Not applicable |
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Not applicable |
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BM02 |
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- |
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White powder |
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Validacin |
Sumitomo Chemical Takeda |
Vivadamy |
Vipseco |
BOC Sciences |
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Usually formulated as a dispersible powder, soluble concentrates and seed treatments |
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610000 |
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High |
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10 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Ethyl acetate |
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26.6 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Acetone |
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62300 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Methanol |
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10 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Toluene |
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125.9 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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814 |
E4 E = Manufacturers safety data sheets 4 = Verified data |
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4.79 X 10-09 |
Calculated |
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-8.32 |
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Low |
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1.4 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
- |
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6.14 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Weak acid |
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2.60 X 10-03 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Low volatility |
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- |
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0.2 |
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Non-persistent |
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- |
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- |
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Best available data DT₅₀ >5hrs rapid microbial degradation |
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Stable |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Stable |
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Stable pH 5 to pH 9 |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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Known soil and groundwater metabolites |
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None
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validoxylamine A |
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None |
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Terrestrial ecotoxicology |
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> 20000 |
Rat |
Low |
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40.4 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Rat |
High |
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- |
- |
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- |
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- |
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12500 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Phasianidae |
Low |
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0.15 |
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High |
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> 40 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Cyprinidae spp. |
Moderate |
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- |
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- |
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> 40 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Daphnia pulex |
Moderate |
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- |
- |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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> 20000 |
Rat |
Low |
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5000 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Rat |
- |
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> 5.0 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Rat 4 hr |
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Carcinogen |
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Endocrine disruptor |
XNo, known not to cause a problem |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative |
XNo, known not to cause a problem |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
XNo, known not to cause a problem |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
XNo, known not to cause a problem |
XNo, known not to cause a problem |
?Possibly, status not identified |
Eye irritant |
Phototoxicant |
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XNo, known not to cause a problem |
No data found |
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Considered practically non-toxic |
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No information available |
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U (Unlikely to present an acute hazard) |
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validamycin A |
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validamycine |
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Validamycin |
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validamycin |
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validamycin |
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validamycin |
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walidamycyna |
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Record last updated: |
07/06/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |