Chlomethoxyfen (Ref: X-52) |

Last updated: 30/05/2024
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(Also known as: chlomethoxynil; diphenex) |
Chlomethoxyfen is a largely obsolete herbicide that was once used to rice weeds. It has a low aqueous solubility and is not volatile. It is not expected to persist in soil systems. It has a low oral toxicity to mammals and is a known skin, eye and respiratory tract irritant as well as being a skin sensitiser. Little is known regarding its potential to cause more serious health issues in humans. There are also significant data gaps regarding its ecotoxicology although some data suggests it is not highly toxic to aquatic organisms. |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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An obsolete pre-emergence herbicide once used mainly in rice to control many annual and some perennial weeds |
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Aquatic Needle Spike Rush (Eleocharis acicularis); Pigmy arrowhead (Sagittaria pygmaea) |
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Paddy rice |
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- |
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Considered obsolete but may be available in some countries |
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- |
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Not approved |
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Expired |
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No UK approval for use as a pesticide |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Expired |
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- |
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Yes |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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None |
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C₁₃H₉Cl₂NO₄ |
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COC1=C(C=CC(=C1)OC2=C(C=C(C=C2)Cl)Cl)[N+](=O)[O-] |
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No data |
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DXXVCXKMSWHGTF-UHFFFAOYSA-N |
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InChI=1S/C13H9Cl2NO4/c1-19-13-7-9(3-4-11(13)16(17)18)20-12-5-2-8(14)6-10(12)15/h2-7H,1H3 |
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Yes |
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Herbicide |
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Nitrophenol ether herbicide |
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- |
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- |
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Synthetic |
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A Protoporphyrinogen oxidase inhibitor. Systemic, selective, rapidly absorbed by roots with limited translocation |
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32861-85-1 |
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251-266-1 |
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8053 |
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Not listed |
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36250 |
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No data found |
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313.0 |
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2,4-dichloro-1-(3-methoxy-4-nitrophenoxy)benzene |
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5-(2,4-dichlorophenoxy)-2-nitroanisole |
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2,4-dichloro-1-(3-methoxy-4-nitrophenoxy)benzene |
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- |
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- |
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E |
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14 |
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Not applicable |
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Not applicable |
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- |
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Powdery solid |
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- Diphenex
- Ekkusugoni
- Condore
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Supplied as a wettable powder or as a granular formulation |
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0.3 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Low |
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200000 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Acetone |
- |
150000 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source benzene |
- |
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113 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.19 X 1003 |
Calculated |
- |
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3.34 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
High |
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- |
- |
- |
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- |
- |
- |
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1.37 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
- |
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- |
- |
- |
- |
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1.87 |
at 25 °C |
Low volatility. If applied directly to plants or soil, drift is a concern & mitigation is advisable |
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1.53 X 10-03 |
at 25 °C |
Non-volatile |
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- |
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25 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Non-persistent |
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- |
- |
- |
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- |
- |
- |
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General literature states DT₅₀ 7-43 days |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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- |
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Non-mobile |
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26291 |
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- |
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-0.59 |
Calculated |
Low leachability |
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5.35 X 10-03 |
Calculated |
- |
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Estimated concentrations of chemicals with Koc values greater than 9995 ml g⁻¹ are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW |
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Medium |
Calculated |
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Non-mobile |
Calculated |
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- |
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None
Terrestrial ecotoxicology |
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> 18000 |
Rat |
Low |
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> 237 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Cyprinus carpio |
Low |
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- |
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> 47.5 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Daphnia magna |
Moderate |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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- |
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> 18000 |
Rat |
Low |
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5000 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Rat |
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EU MRL pesticide database |
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Carcinogen |
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Endocrine disruptor |
?Possibly, status not identified |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
XNo, known not to cause a problem |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
✓Yes, known to cause a problem |
XNo, known not to cause a problem |
Eye irritant |
Phototoxicant |
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✓Yes, known to cause a problem |
No data found |
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CLP data - suspected carcinogen |
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No information available |
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Health: H315, H319, H351 Environment: H400, H410 |
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U (Unlikely to present an acute hazard) |
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chlomethoxyfen |
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chlometoxyfene |
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Chlomethoxyfen |
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chlomethoxyfen |
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clometossifen |
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clometoxifen |
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- |
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chlometoksyfen |
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- |
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- |
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- |
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Record last updated: |
30/05/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |