Nitrofen (Ref: FW-925) |

Last updated: 22/08/2024
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(Also known as: NIP; niclofen; TOK; nitrophen) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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A selective pre- and post-emergent herbicide effective for the control of annual weeds but has been banned in many countries. |
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Annual grasses; Annual broad-leaved weeds |
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Field crops; Ornamentals; Cereals |
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- |
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Considered obsolete but may be available in some countries |
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1964, introduced |
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Not approved |
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Not applicable |
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No UK approval for use as a pesticide |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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Yes |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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None |
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C₁₂H₇Cl₂NO₃ |
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C1=CC(=CC=C1[N+](=O)[O-])OC2=C(C=C(C=C2)Cl)Cl |
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- |
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XITQUSLLOSKDTB-UHFFFAOYSA-N |
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InChI=1S/C12H7Cl2NO3/c13-8-1-6-12(11(14)7-8)18-10-4-2-9(3-5-10)15(16)17/h1-7H |
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Yes |
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Herbicide |
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Diphenyl ether herbicide |
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- |
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- |
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Synthetic |
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Contact action, inhibits noncyclic electron transport distrupting photosynthesis |
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1836-75-5 |
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217-406-0 |
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170 |
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038201 |
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15787 |
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609-040-00-9 |
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284.1 |
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2,4-dichloro-1-(4-nitrophenoxy)benzene |
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2,4-dichlorophenyl 4-nitrophenyl ether |
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2,4-dichloro-1-(4-nitrophenoxy)benzene |
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Banned 1996 but voluntarily withdrawn in 1980; Chemical subject to PIC regulations |
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- |
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E |
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14 |
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Not applicable |
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Not applicable |
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- |
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Colourless, crystalline solid |
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- Chemie AG Bitterfeld-Wolfen
- Rohm & Haas
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- Mezotox
- Niclofen
- NIPR
- Tokkorn
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Usually supplied as a wettable powder or emulsifiable concentrate |
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1.0 |
at 25 °C |
Low |
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40.0 |
Ethanol |
- |
280 |
n-Hexane |
- |
2000 |
Benzene |
- |
250000 |
Acetone |
- |
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67 |
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- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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2.51 X 1003 |
Calculated |
- |
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3.4 |
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
High |
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Soluble |
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- |
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Regulatory data - observed in metabolism and farm animal feeding studies |
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- |
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1.33 |
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
- |
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- |
- |
- |
- |
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1.06 |
at 25 °C |
Low volatility. If applied directly to plants or soil, drift is a concern & mitigation is advisable |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
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10 |
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Non-persistent |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
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- |
- |
- |
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- |
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- |
- |
- |
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- |
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Stable |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Stable |
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- |
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Stable |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Stable |
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- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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- |
Soil adsorption and mobility |
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- |
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Non-mobile |
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10000 |
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Best available data |
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- |
- |
- |
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- |
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- |
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- |
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- |
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0.00 |
Calculated |
Low leachability |
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5.35 X 10-03 |
Calculated |
- |
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Estimated concentrations of chemicals with Koc values greater than 9995 ml g⁻¹ are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW |
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Medium |
Calculated |
- |
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Non-mobile |
Calculated |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
None
Terrestrial ecotoxicology |
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2630 |
Rat |
Low |
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- |
- |
- |
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- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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> 38.0 |
Eisenia foetida |
Moderate |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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> 50 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Moderate |
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- |
- |
- |
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- |
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- |
- |
- |
- |
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- |
- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
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- |
- |
- |
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- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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> 7.0 |
Oncorhynchus mykiss |
Moderate |
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- |
- |
- |
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- |
- |
- |
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> 40.0 |
Daphnia pulex |
Moderate |
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- |
- |
- |
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0.217 |
Ceriodaphnia dubia LC₅₀ |
Moderate |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
HUMAN HEALTH AND PROTECTION |
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High (class III) |
- |
- |
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2630 |
Rat |
Low |
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5000 |
Rat |
- |
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205 |
Rat |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
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May be absorbed through the skin and via inhalation - PPE/PPC advised |
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EU MRL pesticide database |
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- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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Carcinogen |
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Endocrine disruptor |
✓Yes, known to cause a problem |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
✓Yes, known to cause a problem |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
✓Yes, known to cause a problem |
XNo, known not to cause a problem |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
✓Yes, known to cause a problem |
✓Yes, known to cause a problem |
No data found |
Eye irritant |
Phototoxicant |
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✓Yes, known to cause a problem |
No data found |
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Thyroid hormone toxicant Teratogen Endocrine issues - Estrogen and androgen inhibition CLP data - known human carcinogen; US NTP - suspected carcinogen |
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Prevent generation of dust Combustable |
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Health: H302, H350, H360D Environment: H400, H410 |
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III (Slightly hazardous) |
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- |
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- |
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- |
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nitrofen |
|
nitrofene |
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- |
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- |
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- |
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- |
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- |
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- |
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- |
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- |
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- |
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- |
Record last updated: |
22/08/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |