Flupyradifurone (Ref: BYI 02960) |
Last updated: 29/08/2024 |
(Not known by any other names) |
SUMMARY |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
---|---|---|
|
|
An insecticide used to control sucking pests in a variety of cropping situations. | |
---|---|---|
|
Aphids, Hoppers, Whiteflies, Cicadas, Colorado potato beetle, Squash bugs, Psyllids. | |
|
Vegetables; Fruits; Grapes; Date palm; Coffee; Cocoa | |
|
- | |
|
Current | |
|
2012 discovered |
UK regulatory status |
|
Approved | ||
---|---|---|---|
|
09/12/2025 | ||
|
None |
EC Regulation 1107/2009 (repealing 91/414) |
|
Approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Netherlands | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
09/12/2025 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
Additional information |
|
USA, Iran, Morocco |
---|
Chemical structure |
|
None | |
---|---|---|
|
C₁₂H₁₁ClF₂N₂O₂ | |
|
C1C(=CC(=O)O1)N(CC2=CN=C(C=C2)Cl)CC(F)F | |
|
- | |
|
QOIYTRGFOFZNKF-UHFFFAOYSA-N | |
|
InChI=1S/C11H9ClF2N2O2/c12-9-2-1-7(4-15-9)16(5-10(13)14)8-3-11(17)18-6-8/h1-4,10H,5-6H2 | |
|
Yes |
General status |
|
Insecticide | |
---|---|---|
|
Organofluoride insecticide; Monochloropyridine insecticide; butenolide Insecticide | |
|
>960 g kg⁻¹ | |
|
EU Dossier: none delcared | |
|
Synthetic | |
|
Systemic. It is an adult knockdown product that also offers some control of nymph and egg stages. Nicotinic acetylcholine receptor (nAChR) channel blocker. | |
|
951659-40-8 | |
|
804-373-8 | |
|
987 | |
|
122304 | |
|
16752772 | |
|
607-741-00-4 | |
|
288.68 | |
|
4-([(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino)furan-2(5H)-one | |
|
4-((6-chloro-3-pyridylmethyl)(2,2-difluoroethyl)amino)furan-2(5H)-one | |
|
4-(((6-chloro-3-pyridinyl)methyl)(2,2-difluoroethyl)amino)-2(5H)-furanone | |
|
- | |
|
- | |
|
Not applicable | |
|
Not applicable | |
|
4D | |
|
Not applicable | |
|
- | |
|
White powder with weak, uncharacteristic odour at 99.4% purity |
Formulations |
|
|
|||
---|---|---|---|---|
|
|
|||
|
|
|||
|
The main available formulations are those for foliar and drench/drip use and a seed treatment |
|
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
3200 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
|
0.05 | E4 E = Manufacturers safety data sheets n-Heptane4 = Verified data |
- | ||||||||
3700 | E4 E = Manufacturers safety data sheets Toluene4 = Verified data |
- | |||||||||
250000 | E4 E = Manufacturers safety data sheets Ethyl acetate4 = Verified data |
- | |||||||||
250000 | E4 E = Manufacturers safety data sheets Methanol4 = Verified data |
- | |||||||||
|
69.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
|
Decomposes before boiling | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
|
270 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
|
- | - | - | ||||||||
|
|
1.58 X 1001 | Calculated | - | |||||||
|
1.2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) at 25 °C5 = Verified data used for regulatory purposes |
Low | ||||||||
|
|
Insoluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | |||||||
|
Regulatory data - observed in metabolism and farm animal feeding studies | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
|
1.43 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
|
- | - | - | ||||||||
No dissociation | |||||||||||
|
9.1 X 10-04 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility | ||||||||
|
8.2 X 10-08 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-volatile | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
pH 7.0: 213nm=9615; 259nm=25800 pH 2.0: 214nm=9389, 259nm=26577 pH 10.0: 213nm=9996; 259nm=25955 |
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
|
- | - | - |
Degradation |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
- | ||||||||||
|
|
57.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately persistent | |||||||
|
57.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately persistent | ||||||||
|
130 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Persistent | ||||||||
|
522.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Very persistent | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
EU dossier lab studies DT₅₀ range 38.6-210 days, DT₉₀ range 209-898 days, Soils =16; Manufacturers data DT₅₀ lab studies range 33-371 days; DT₅₀ field ranges 8.3 - 251 days | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
0.35 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Fast | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
230 | E4 E = Manufacturers safety data sheets 4 = Verified data |
Slow | ||||||||
|
31.4 | E4 E = Manufacturers safety data sheets 4 = Verified data |
Stable | ||||||||
|
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
|
- |
Soil adsorption and mobility |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
- | E4 E = Manufacturers safety data sheets 4 = Verified data |
Moderately mobile | |||||||
|
98.4 | ||||||||||
|
Data for European and US soils; Brazilian soils Koc = 333 mL g⁻¹ | ||||||||||
|
|
2.26 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately mobile | |||||||
|
98.4 | ||||||||||
|
0.866 | ||||||||||
|
EU dossier Kf range 0.597-3.822 mL g⁻¹, Kfoc range 85.2-132.2 mL g⁻¹, 1/n range 0.845-0.902, Soils=6 | ||||||||||
|
None |
Fate indices |
|
|
|
|
||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
4.24 | Calculated | High leachability | ||||||||||||||||||||||||||
|
|
1.77 X 1000 | Calculated | - | |||||||||||||||||||||||||
|
- | ||||||||||||||||||||||||||||
|
Medium | Calculated | - | ||||||||||||||||||||||||||
|
Moderately mobile | Calculated | - | ||||||||||||||||||||||||||
|
4.4 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Calculated using the Atkinson method. Assumed 1.5E+06 OH/cm³, 12 hr5 = Verified data used for regulatory purposes |
Below the level of concern for long-range air transport | ||||||||||||||||||||||||||
|
|
- | - | - | |||||||||||||||||||||||||
|
- | - |
Known soil metabolites |
|
|
|
|
|||||
---|---|---|---|---|---|---|---|---|
|
- | - | - | |||||
|
Major fraction | 0.171 | - | |||||
|
Major fraction | 0.339 | - |
Known groundwater metabolites |
|
|
|
|
||||||
---|---|---|---|---|---|---|---|---|---|
|
Not relevant | - | - | ||||||
|
Not relevant | - | - |
Other known metabolites |
|
|
|
|
||||
---|---|---|---|---|---|---|---|
4-[(2,2-difluoroethyl)amino]furan-2(5H)-one | DFEAF | Plant; Livestock; Water | - | ||||
(6-chloropyridin-3-yl)methanol | CHMP | - | - | ||||
flupyradifuronehydroxy | BYI 02960-hydroxy | - | - | ||||
flupyradifuronesuccinamide | BYI 02960-succinamide | - | - | ||||
flupyradifuroneazabicyclosuccinamide | BYI 02960-azabicyclosuccinamide | - | - |
|
Terrestrial ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
> 300 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
|
|
- | - | - | |||||||
|
- | - | |||||||||
|
- | - | - | ||||||||
|
232 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Colinus virginianus5 = Verified data used for regulatory purposes |
Moderate | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
185.6 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida5 = Verified data used for regulatory purposes |
Moderate | ||||||||
|
- | - | - | ||||||||
|
Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect |
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Dose: 3.34 mg kg⁻¹ soil 28 Day |
- | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
- | - | - | |||||||||
|
|
> 200 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Apis mellifera5 = Verified data used for regulatory purposes |
Low | |||||||
|
1.2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Apis mellifera5 = Verified data used for regulatory purposes |
Moderate | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
> 100 | R3 R = Peer reviewed scientific publications Bombus terrestris3 = Unverified data of known source |
Low | |||||||
- | |||||||||||
|
> 1.7 | R4 R = Peer reviewed scientific publications Bombus impatiens 48 hr4 = Verified data |
Moderate | ||||||||
- | |||||||||||
|
|
10.59 | R4 R = Peer reviewed scientific publications Osmia bicornis4 = Verified data |
Moderate | |||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
273.9 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Coccinella septempunctata Larva5 = Verified data used for regulatory purposes |
- | ||||||||
|
- | - | - | ||||||||
|
< 0.5 | E4 E = Manufacturers safety data sheets Aphidius rhopalosiphi4 = Verified data |
- | ||||||||
|
17.3 | E4 E = Manufacturers safety data sheets Typhlodromus pyri4 = Verified data |
- | ||||||||
|
- | - | - |
Aquatic ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
> 70.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Pimephales promelas5 = Verified data used for regulatory purposes |
Moderate | ||||||||
|
4.4 | E4 E = Manufacturers safety data sheets Pimephales promelas4 = Verified data |
Moderate | ||||||||
|
- | - | - | ||||||||
|
> 77.6 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
Moderate | ||||||||
|
3.2 | E4 E = Manufacturers safety data sheets Daphnia magna4 = Verified data |
Moderate | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
> 67.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Lemna gibba5 = Verified data used for regulatory purposes |
Low | ||||||||
|
> 100 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Pseudokirchneriella subcapitata5 = Verified data used for regulatory purposes |
Low | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - |
|
- | - | - |
|
General |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
High (class III) | - | - | ||||||||
|
> 300 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
|
2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
- | ||||||||
|
> 4.67 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
- | ||||||||
|
- | - | - | ||||||||
|
0.064 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
- | ||||||||
|
0.15 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rabbit SF=1005 = Verified data used for regulatory purposes |
- | ||||||||
|
- | - | - | ||||||||
|
0.064 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
- | ||||||||
|
0.4-17 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) concentration dependent4 = Verified data |
- | ||||||||
|
- | - | - | ||||||||
|
|
- | |||||||||
|
- | ||||||||||
|
|
|
|||||||||
|
|
||||||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
Main route of excretion is renal | E4 E = Manufacturers safety data sheets 4 = Verified data |
- |
Health issues |
|
|
||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Liver and thyroid target organs |
Handling issues |
|
|
|||
---|---|---|---|---|
|
Not explosive or oxidising Not expected to auto-ignite; Not highly flammable |
|||
|
Health: H302, H373 Environment: H400, H410, H412 |
|||
|
II (Moderately hazardous) | |||
|
- | |||
|
- | |||
|
- |
|
|
|
||
---|---|---|---|
|
flupyradifurone | ||
|
flupyradifurone | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
flupyradifuron |
Record last updated: | 29/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |