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Dimpropyridaz
Last updated: 14/03/2024
(Also known as: trinconazole; Acetazolamide)

SUMMARY
Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate Ecotoxicity Human health
Environmental fate
Moderate alert:
GUS: Transition state; Drainflow: Moderately mobile
Ecotoxicity
Moderate alert:
Birds acute ecotoxicity: Moderate; Birds chronic ecotoxicity: Moderate; Fish acute ecotoxicity: Moderate; Daphnia acute ecotoxicity: Moderate; Bees acute contact ecotoxicity: Moderate; Bees acute oral ecotoxicity: Moderate; Bees acute unknown ecotoxicity: Moderate
Human health
Moderate alert:
Mammals acute toxicity: Moderate
GENERAL INFORMATION
Description
A pro-insecticide used to control sucking and chewing insect pests. Dimpropyridaz forms the secondary amide metabolite (pyridazine pyrazolecarboxamide), which is biologically active.
Example pests controlled
Aphids; Whiteflies;Thrips; Scale insects; Mealybugs; Psyllids; Leafhoppers
Example applications
Fruit; Vegetables including brassicas,; Grapes; Potatoes; Soybean; Beet; Oilseed rape; Ornamentals; Cotton
Efficacy & activity
Efficacy demonstrated by extensive field and glasshouse trials across across major growing regions of Australia & Tasmania
Availability status
Novel
Introduction & key dates
2019, launch; 2021, first product registered Australia
UK regulatory status
UK COPR regulatory status
Not approved
Date COPR inclusion expires
Not applicable
UK LERAP status
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Pending
Dossier rapporteur/co-rapporteur
Austria
Date EC 1107/2009 inclusion expires
Not applicable
EU Candidate for substitution (CfS)
No
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
                 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
               
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
                 
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
                 
Additional information
Also used in
Australia, Korea, Japan
Chemical structure
Isomerism
Substance is racemic. The S-entamiomer is the preferential form displaying greater biological activity
Chemical formula
C₁₆H₂₃N₅O
Canonical SMILES
-
Isomeric SMILES
-
International Chemical Identifier key (InChIKey)
NQPGZXOPMRKAGJ-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C16H23N5O/c1-6-20(14-7-8-17-18-9-14)16(22)15-10-19-21(13(15)5)12(4)11(2)3/h7-12H,6H2,1-5H3
2D structure diagram/image available?
Yes
General status
Pesticide type
Insecticide
Substance groups
Pyrazolecarboxamide insecticide; Carboximide insecticide
Minimum active substance purity
-
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
Disrupts the function of insects sensory chordotonal organs
CAS RN
1403615-77-9
EC number
No data found
CIPAC number
None allocated
US EPA chemical code
-
PubChem CID
-
CLP index number
No data found
Molecular mass
301.39
PIN (Preferred Identification Name)
rac-N-ethyl-5-methyl-1-[(2R)-3-methylbutan-2-yl]-N-(pyridazin-4-yl)-1H-pyrazole-4-carboxamide
IUPAC name
1-[(1RS)-1,2-dimethylpropyl]-N-ethyl-5-methyl-N-pyridazin-4-yl-1H-pyrazole-4-carboxamide
CAS name
1-(1,2-dimethylpropyl)-N-ethyl-5-methyl-N-4-pyridazinyl-1H-pyrazole-4-carboxamide
Other status information
-
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Class (HRAC MoA class)
Not applicable
Herbicide Resistance Class (WSSA MoA class)
Not applicable
Insecticide Resistance Class (IRAC MoA class)
36
Fungicide Resistance Class (FRAC MOA class)
Not applicable
Examples of recorded resistance
-
Physical state
Tan to white coloured powdery solid
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
Example products using this active
  • Axalion
  • Efficon
Formulation and application details
Various formulations available including foliar sprays. denches and dips
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
28700
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
High
Solubility - In organic solvents at 20 °C (mg l⁻¹)
10000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
n-Heptane
-
67000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Xylene
-
250000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Acetone
-
250000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Ethyl acetate
-
Melting point (°C)
81.9
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
-
Boiling point (°C)
- - -
Degradation point (°C)
208
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
-
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
1.26 X 1001 Calculated -
Log P
1.1
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Low
Fat solubility of residues
Solubility
- - -
Data type
- - -
Density (g ml⁻¹)
- - -
Dissociation constant pKa) at 25 °C
No dissociation
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
-
-
Vapour pressure at 20 °C (mPa)
8.7 X 10-03
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
- - -
Volatilisation as max % of applied dose lost
From plant surface
- - -
From soil surface
- - -
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
- - -
Surface tension (mN m⁻¹)
52.9
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
at 20 °C 90% soln
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
Not readily biodegradable
Soil degradation (days) (aerobic)
DT₅₀ (typical)
30
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Moderately persistent
DT₅₀ (lab at 20 °C)
30
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Moderately persistent
DT₅₀ (field)
22
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Non-persistent
DT₉₀ (lab at 20 °C)
- - -
DT₉₀ (field)
- - -
DT₅₀ modelling endpoint
- - -
Note
Australian Dossier 2022: Lab studies DT₅₀ range 16-98 days, Soils=4; Field studies DT₅₀ range 9.1-81 days, Soils=12
Dissipation rate RL₅₀ (days) on plant matrix
Value
- - -
Note
-
Dissipation rate RL₅₀ (days) on and in plant matrix
Value
- - -
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
47
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Stable
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
185
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Persistent
Note
-
Water-sediment DT₅₀ (days)
101.5
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Slow
Water phase only DT₅₀ (days)
120
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Stable
Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀
-
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd (mL g⁻¹)
- - -
Koc (mL g⁻¹)
-
Notes and range
-
Freundlich
Kf (mL g⁻¹)
2.58
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Moderately mobile
Kfoc (mL g⁻¹)
135.5
1/n
-
Notes and range
Australian dossier 2022. Kf range 0.1705.0 mL g⁻¹; Kfoc range 19-248 mL g⁻¹
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
2.51 Calculated Transition state
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
1.26 X 10-01 Calculated -
Note
-
Potential for particle bound transport index
Low Calculated -
Potential for loss via drain flow
Moderately mobile Calculated -
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
- - -
Bio-concentration factor
BCF (l kg⁻¹)
- - -
CT₅₀ (days)
- -
Known soil metabolites
Metabolite
Major/Minor fraction
Estimated maximum occurrence fraction
Notes
Ref: M550I001
Major fraction 0.510 -
Ref: M550I004
Major fraction 0.100 -
Ref: M550I005
- - -
Known groundwater metabolites

None

Other known metabolites

None

ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
465
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Rat
Moderate
Mammals - Short term dietary NOEL
(mg kg⁻¹)
- - -
(ppm diet)
- -
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
- - -
Birds - Acute LD₅₀ (mg kg⁻¹)
1778
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Colinus virginianus
Moderate
Birds - Short term dietary (LC₅₀/LD₅₀)
- - -
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
97
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Colinus virginianus
Moderate
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
> 1000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Eisenia foetida
Low
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
> 285
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Eisenia foetida
Low
Soil micro-organisms
- - -
Collembola
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
- - -
Non-target plants
> 300
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
10 terrestrial plant
ER₅₀
Tested at a single application rate of 300 g ai./ha
-
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 50
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Lowest of 2 bee species
Moderate
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 42
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Lowest of 2 bee species
Moderate
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 45
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Bee larvae
Moderate
Chronic
- - -
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other bee species (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other bee species (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Beneficial insects (Ladybirds)
- - -
Beneficial insects (Lacewings)
- - -
Beneficial insects (Parasitic wasps) Mortality LR₅₀
34
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Aphidius rhopalosiphi
-
Beneficial insects (Predatory mites) Mortality LR₅₀
546
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Typhlodromus pyr
-
Beneficial insects (Ground beetles)
- - -
Aquatic ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
> 30
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Unknown species
Moderate
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)
11.0
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Pimephales promelas
Low
Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
> 30
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Daphnia magna
Moderate
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
- - -
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
> 105
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Colinus virginianus
Low
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
- - -
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
> 95.0
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Pseudokirchneriella subcapitata as ErC50
Low
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
465
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Rat
Moderate
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
2000
E4 E = Manufacturers safety data sheets
4 = Verified data
Rat
-
Mammals - Inhalation LC₅₀ (mg l⁻¹)
- - -
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.2
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Australia
-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
None allocated
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Australia
-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
- - -
Dermal penetration studies (%)
- - -
Dangerous Substances Directive 76/464
- - -
Exposure Routes
Public
-
Occupational
-
MRLs
European
EU MRL pesticide database 
Great Britain
GB MRL Register 
Notes
-
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Mammalian dose elimination route and rate
- - -
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database)
0 = No data
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source)
3 = Negative
No data found
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
XNo, known not to cause a problem
No data found
XNo, known not to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
No data found
?Possibly, status not identified
XNo, known not to cause a problem
Eye irritant Phototoxicant  
?Possibly, status not identified
XNo, known not to cause a problem
 
General human health issues
No information available
Handling issues
Property
Value and interpretation
General
No explosive or oxidising
Not expe cted to auto-ignite; Not highly flammable
CLP classification 2013
-
WHO Classification
Not listed (Not listed)
UN Number
-
Waste disposal & packaging
-
Shelf-life, storage, stability and reactivity
Stable for approx. 2 yrs at 20 degC
TRANSLATIONS
Language
Name
English
dimpropyridaz
French
dimpropyridaz
German
-
Danish
-
Italian
-
Spanish
-
Greek
-
Polish
-
Swedish
-
Hungarian
-
Dutch
-
Norwegian
-

Record last updated: 14/03/2024
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242