Spinetoram J (Ref: XDE-175-J ) |
Last updated: 31/10/2024 |
(Not known by any other names) |
SUMMARY |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A natural fermentation-derived substance with activity against a wide range of common insect pests | |
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Apple moth; Grapevine moth; Codling moth; Oriental fruit moth; Western flower thrip; Pear & cherry slug; | |
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Fruit including grapes, apples, pears, apricots, cherries, plums, peaches | |
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Current | |
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2007, first registered USA |
UK regulatory status |
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Not approved | ||
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Withdrawn | ||
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None |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Croatia/Spain | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information |
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USA (pending) |
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Chemical structure |
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Spinetoram J is the major component of spinetoram technical material. It is not an isomer of spinetoram but contains an extra methyl group. | |
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C₄₂H₆₉NO₁₀ | |
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CCC1CCCC(C(C(=O)C2=CC3C(C2CC(=O)O1)CCC4C3CC(C4)OC5C(C(C(C(O5)C)OC)OCC)OC)C)OC6CCC(C(O6)C)N(C)C | |
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CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@@H]3[C@H]([C@@H]2CC(=O)O1)CC[C@H]4[C@H]3C[C@@H](C4)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OCC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C | |
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GOENIMGKWNZVDA-RWGFPKGXSA-N | |
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InChI=1S/C42H69NO10/c1-10-27-13-12-14-35(53-37-18-17-34(43(6)7)24(4)49-37)23(3)38(45)33-21-31-29(32(33)22-36(44)51-27)16-15-26-19-28(20-30(26)31)52-42-41(47-9)40(48-11-2)39(46-8)25(5)50-42/h21,23-32,34-35,37,39-42H,10-20,22H2,1-9H3/t23-,24-,25+,26-,27+,28-,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+/m1/s1 | |
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Yes |
General status |
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Insecticide | |
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Spinosyn insecticide | |
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[Typically >95%] | |
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EU dossier - none declared | |
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Semi-synthetic | |
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Shows high residual, contact and ingestion activity. Nicotinic acetylcholine receptor (nAChR) channel blocker - site I | |
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187166-40-1 | |
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803-245-9 | |
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802 | |
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110008 | |
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24795086 | |
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No data found | |
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748.0 | |
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- | |
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(1S,2R,5R,7R,9R,10S,14R,15S,19S)-15-[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-7-[(2R,3R,4R,5S,6S)-4-ethoxy-3,5-dimethoxy-6-methyloxan-2-yl]oxy-19-ethyl-14-methyl-20-oxatetracyclo[10.10.0.02,10.05,9]docos-11-ene-13,21-dione | |
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PAN listed Highly Hazardous Chemical | |
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Not applicable | |
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Not applicable | |
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5 | |
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Not applicable | |
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Off-white solid | |
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Formulations |
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29.0 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
Low | ||||||||
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250000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Methanol5 = Verified data used for regulatory purposes |
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250000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Acetone5 = Verified data used for regulatory purposes |
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250000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Xylene5 = Verified data used for regulatory purposes |
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61000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) n-Heptane5 = Verified data used for regulatory purposes |
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75 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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803.5 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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1.23 X 1004 | Calculated | - | |||||||
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4.09 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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5.7 X 10-02 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
Low volatility | ||||||||
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4.0 X 10-03 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
Non-volatile | ||||||||
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Neutral soln.: 245nm=12200 Acidic soln.: 247nm=12400 Basic soln.: 247nm=12400 |
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Degradation |
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16.1 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
Non-persistent | |||||||
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16.1 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
Non-persistent | ||||||||
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2.8 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
Non-persistent | ||||||||
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87.0 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
Moderately persistent | ||||||||
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31.1 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
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EU dossier for spinetoram Lab studies DT₅₀ range 5-86.9 days, DT₉₀ range 27.1-420.0 days, additional study 72881 days; Field studies XDE-175-J: DT₅₀ range 0.03-2.49 days, DT₉₀ 1.6-25.7, XDE-175-L: DT₅₀ range 0.07-2.0, DT₉₀ range 0.51-7.91 days; Manufacturer published data gives field studies DT₅₀ 3-5 days, lab studies DT₅₀ 13-21 days | ||||||||||
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0.4 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
Fast | |||||||
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DT₅₀ 0.3-0.5 days summer sunlight 40 Deg N | ||||||||||
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Stable | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
Stable | |||||||
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Stable pH 5 to pH 9 at 25 °C | ||||||||||
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273 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
Slow | ||||||||
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5.1 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram4 = Verified data |
Moderately fast | ||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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37.3 | E4 E = Manufacturers safety data sheets 4 = Verified data |
Non-mobile | |||||||
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22836 | ||||||||||
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EU dossier for spinetoram Kd range 12-61 mL g⁻¹, Koc range 1470-5490, soils=10; Manufacturer published data Koc = 1800-43873 mL g⁻¹ | ||||||||||
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32 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Slightly mobile | |||||||
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2544 | ||||||||||
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0.949 | ||||||||||
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EU dossier for spinetoram Kf range 8.6-43.8 mL g⁻¹, Kfoc range 1263-6257 mL g⁻¹, 1/n range 0.83-1.11, Soils=10 | ||||||||||
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None |
Fate indices |
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0.27 | Calculated | Low leachability | ||||||||||||||||||||||||||
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1.05 X 10-03 | Calculated | - | |||||||||||||||||||||||||
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Medium | Calculated | - | ||||||||||||||||||||||||||
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Non-mobile | Calculated | - | ||||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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5000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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> 5.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat 4 hr5 = Verified data used for regulatory purposes |
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0.025 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram5 = Verified data used for regulatory purposes |
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0.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram5 = Verified data used for regulatory purposes |
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0.0065 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as spinetoram5 = Verified data used for regulatory purposes |
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5-11 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) concentration dependent5 = Verified data used for regulatory purposes |
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Acceptable for proposed uses | |||||||||
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Acceptable for proposed uses | ||||||||||
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GB MRL levels for spinetoram on lettuce subject to change in May 2023 | ||||||||||
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85% eliminated via the faeces majority of which is lost in the first 24hrs | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Potential for slow accumulation in the body Possible thyroid toxicant Weak sensitiser |
Handling issues |
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Not explosive or oxidising Not expected to auto-ignite; Not highly flammable |
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Health: H317, H361 Environment: H400, H410 |
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U (Unlikely to present an acute hazard) | |||
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spinetoram J | ||
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espinetoram J | ||
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Record last updated: | 31/10/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |