Triclocarban (Ref: ENT 26925)

Triclocarban (Ref: ENT 26925)	Last updated: 20/10/2026
(Also known as: TCC; trichlorocarbanilide)

SUMMARY

Hazard alerts

The following Pesticide Hazard Tricolour (PHT) alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. The alerts for Highly Hazardous Pesticides (HHPs) are based on applying the FAO/WHO (Type 1) and the PAN (Type II) criteria to PPDB data. Further details on the HHP indicators are given in the tables below. Neither the PHT nor the HHP hazard alerts take account of usage patterns or exposure, thus they do not represent risk.

PHT: Environmental fate	PHT: Ecotoxicity	PHT: Human health	Highly Hazardous Pesticide
Environmental fate High alert: Potential for particle bound transport: High Warning: Significant data are missing	Ecotoxicity High alert: Fish acute ecotoxicity: High; Daphnia acute ecotoxicity: High Warning: Significant data are missing	Human health High alert: Reproduction/development effects	Highly Hazardous Pesticide (HHP) Type II alert

GENERAL INFORMATION

Description

Triclocarban is a synthetic, broad-spectrum antibacterial and antifungal substance widely used in hygiene products

Example pests/issues controlled

Gram-positive bacteria

Example applications

Consumer hygiene products

Efficacy & activity

GB regulatory status

GB Retained EC Regulation 1107/2009 status

Not approved

Date GB regulatory inclusion expires

Not applicable

GB LERAP status

No GB approval as crop protection agent

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Not approved

Dossier rapporteur/co-rapporteur

Not applicable

Date EC 1107/2009 inclusion expires

Not applicable

EU Candidate for substitution (CfS)

Not applicable

Listed in EU database

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece

ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg

LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway

Additional information

Also used in

Chemical structure

Isomerism

Triclocarban is isomeric. It exhibits constitutional isomerism because its three chlorine atoms can be rearranged into different positions on its two phenyl rings to form entirely distinct chemical structures. Additionally, it displays conformational isomerism (rotamers) because the partial double-bond character within its central urea linkage restricts rotation, forcing the molecule into different spatial orientations (such as cis and trans forms) depending on its environment.

Chemical formula

C₁₃H₉Cl₃N₂O

Canonical SMILES

C1=CC(=CC=C1NC(=O)NC2=CC(=C(C=C2)Cl)Cl)Cl

Isomeric SMILES

International Chemical Identifier key (InChIKey)

ICUTUKXCWQYESQ-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C13H9Cl3N2O/c14-8-1-3-9(4-2-8)17-13(19)18-10-5-6-11(15)12(16)7-10/h1-7H,(H2,17,18,19)

2D structure diagram/image available?

Yes

Cambridge Crystallographic Data Centre diagrams

Common Name	Relationship	Link
triclocarban	-

General status

Pesticide type

Fungicide; Other substance

Other bioactivity & uses

Preservative; Antimicrobial; Disinfectant

Substance groups

Phenylurea

Minimum active substance purity

Known relevant impurities

Substance origin

Synthetic

Mode of action

It works as a bacteriostatic agent that inhibits bacterial fatty acid synthesis and cell membrane growth

CAS RN

101-20-2

EC number

202-924-1

CIPAC number

US EPA chemical code

027901

PubChem CID

7547

Molecular mass (Da)

315.59

PIN (Preferred Identification Name)

1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea

IUPAC name

1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea

CAS name

N-(3,4-dichlorophenyl)-N'-(4-chlorophenyl)urea

Global Governance status: Listed (✓) under

UK Poisons List Order 1972	Rotterdam Convention	Montreal Protocol
XNo The Poisons List Order 1972	XNo Rotterdam Convention	XNo Montreal Protocol
Stockholm Convention	OSPAR	EU Water Framework Directive
XNo Stockholm Convention	XNo OSPAR	XNo EU Water Framework Directive

Relevant Environmental Water Quality Standards

Forever chemical

Highly Hazardous Pesticide (HHP)

Type I

Type II

Yes []

Other status information

Herbicide Resistance Class (HRAC MoA class)

Not applicable

Herbicide Resistance Class (WSSA MoA class)

Not applicable

Insecticide Resistance Class (IRAC MoA class)

Not applicable

Fungicide Resistance Class (FRAC MOA class)

Not applicable

Examples of recorded resistance

Physical state

Fine white flaky plates or white powder

Commercial

Property

Value

Availability status

Current

Introduction & key dates

1957, introduced in household products; 2016, banned in US consumer hygiene products

Example manufacturers & suppliers of products using this active now or historically

Lanxess
BASF plc
Solvay

Example products using this active

Example products using this substance as a possible coformulant

Formulation and application details

Supplied commercially as a powder.

Commercial production

Triclocarban is commercially produced through a addition reaction that bonds an amine to an isocyanate to form a central urea linkage. This industrial synthesis is typically achieved via two main chemical pathways: reacting 4-chlorophenyl isocyanate with 3,4-dichloroaniline, or reacting 3,4-dichlorophenyl isocyanate with 4-chloroaniline. Because this process couples the two chlorinated phenyl rings cleanly without creating chemical byproducts, it yields a highly pure white powder with a typical commercial purity of 98% to 99% w/w.

Impact on climate of production and use

The production of triclocarban impacts climate change primarily through the energy-intensive manufacturing of its synthetic raw materials, fossil fuel consumption, and downstream disruption of wastewater treatment systems. There is no publicly available data on its GHG production but the baseline for chlorinated aromatics is typically 2 to 5 kg of CO₂-e per kg of product.

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C at pH 7 (mg l⁻¹)

0.11

Low

Solubility - In organic solvents at 20 °C (mg l⁻¹)

1600

Methanol

Melting point (°C)

Boiling point (°C)

250

Degradation point (°C)

Flashpoint (°C)

Octanol-water partition coefficient at pH 7, 20 °C

2.20 X 10⁰⁴

Calculated

Log P

4.342

at 25 °C

High

Fat solubility of residues

Solubility

Data type

Density (g ml⁻¹)

Dissociation constant pKa) at 25 °C

12.7

Vapour pressure at 20 °C (mPa)

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

Volatilisation as max % of applied dose lost

From plant surface

From soil surface

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Surface tension (mN m⁻¹)

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (Research showed less than 2% to 4% degradation even after 7.5 months under aerobic conditions)

DT₅₀ (typical)

108

Persistent

DT₅₀ (lab at 20 °C)

DT₅₀ (field)

DT₉₀ (lab at 20 °C)

DT₉₀ (field)

DT₅₀ modelling endpoint

Note

Soil mineralisation

Aerobic (at 20 °C)

Anaerobic (at 20 °C)

Dissipation rate RL₅₀ (days) on plant matrix

Value

Note

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Note

Water-sediment DT₅₀ (days)

Water phase only DT₅₀ (days)

Sediment phase only DT₅₀ (days)

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

Non-mobile

K_oc (mL g⁻¹)

50000

Notes and range

Published data range 12,000 to over 71,000 ml/g

Freundlich

K_f (mL g⁻¹)

K_foc (mL g⁻¹)

¹/_n

Notes and range

pH sensitivity

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

-1.42

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

5.35 X 10^-03

Calculated

Note

Estimated concentrations of chemicals with Koc values greater than 9995 ml g⁻¹ are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW

Potential for particle bound transport index

High

Calculated

Potential for loss via drain flow

Non-mobile

Calculated

Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk

Bio-concentration factor

BCF (l kg⁻¹)

CT₅₀ (days)

Known soil metabolites

Metabolite

Major/Minor fraction

$Click here for further information on Major/Minor fraction$

Estimated maximum occurrence fraction

Notes

3,4-dichloroaniline

carbanilide

Known groundwater metabolites

None

Other known metabolites

None

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 5000

Mouse

Low

Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Rat

Moderate

Birds - Acute LD₅₀ (mg kg⁻¹)

Birds - Short term dietary LC₅₀ (mg kg⁻¹ bw d⁻¹)

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹ dw soil)

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹ dw soil)

Soil micro-organisms

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

Non-target plants

Vegetative vigour ER₅₀ (g ha⁻¹)

Seedling emergence ER₅₀ (g ha⁻¹)

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic

Notes

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds)

Beneficial insects (Lacewings)

Beneficial insects (Parasitic wasps)

Beneficial insects (Predatory mites)

Beneficial insects (Ground beetles)

Beneficial insects (Butterflies)

Contact

Notes

Oral

Notes

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

> 0.028

Lepomis macrochirus

High

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

0.01

Pimephales promelas

Moderate

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

0.013

Daphnia magna

High

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

0.010

Daphnia magna

Moderate

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l⁻¹)

Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l⁻¹)

Algae - Acute (growth rate, fresh; mg l⁻¹)

Algae - Chronic (growth rate, fresh; mg l⁻¹) (NOEC)

0.057

Pseudokirchneriella subcapitata

Moderate

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves

Regulatory Threshold Levels (RTLs)

Note: These RTLs have been calculated using the regulatory approach used in the European Union and based on ecotoxocity values in the PPDB.

Species group

RTL

Notes

Mammals

Worst case of acute and chronic mammals

Birds

No data

No data for acute and chronic birds

Soil organisms

No data

No data for acute and chronic earthworms

Terrestrial plants

No data

No data for non-target plants vegetative vigour and seedling emergence

Pollinators

No data

No data for contact and oral honeybees

Arthropods

No data

No data for parasitic wasps and predatory mites

Fish

0.00028

Worst case of temperate acute and chronic fish

Aquatic invertebrates

0.00013

Worst case of temperate acute and chronic aquatic invertebrates

Aquatic plants

0.057

Worst case of free-floating plants, rooted plants, acute and chronic algae

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 5000

Mouse

Low

Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Rat

Moderate

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

> 10000

Rabbit

Mammals - Inhalation LC₅₀ (mg l⁻¹)

Other Mammal toxicity endpoints

LD₅₀ Intraperitoneal = 2100 mg kg bw⁻¹ day⁻¹

Mouse

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

Dermal penetration studies (%)

Dangerous Substances Directive 76/464

Exposure Routes

Public

Occupational

MRLs

European

EU MRL pesticide database

Great Britain

GB MRL Register

Notes

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Mammalian dose elimination route and rate

Absorbed through the skin & excreted in urine as N-glucuronides

Health issues

Specific human health issues (hazard-based)

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

No data found

Respiratory tract irritant

Skin irritant

Skin sensitiser

No data found

Eye irritant

Phototoxicant

No data found

General human health issues

May disturb the gut microbiome
May induce allergic reactions
Suspected endocrine disrupter

Handling issues

Property

Value and interpretation

General

Hazardous decomposition products formed on heating to decomposition - carbon oxides, nitrogen oxides

CLP classification 2013

WHO Classification

UN Number

Waste disposal & packaging

Shelf-life, storage, stability and reactivity

Stable under recommended storage conditions.

TRANSLATIONS

Language

Name

English

triclocarban

French

German

Danish

Italian

Spanish

Greek

Polish

Swedish

Hungarian

Dutch

Norwegian

Record last updated:

20/10/2026

Contact:

aeru@herts.ac.uk

Please cite as:

Tzilivakis, J., Lewis, K.A., Green, A. and Warner, D.J. (2026) A decade of growth and impact of the Pesticide Properties Database (PPDB). Human and Ecological Risk Assessment: An International Journal, 32(6), 1104-1129. DOI: 10.1080/10807039.2026.2702066

Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242

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