Pirimiphos-methyl (Ref: OMS 1424) |
Last updated: 22/08/2024 |
(Also known as: pyrimiphos-méthyl; PP 511) |
SUMMARY |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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An organophosphate fumigant insecticide used to control a wide range of insects and mites | |
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Grain weevils; Common flour mite; Warehouse moth; Mill moth; Flour beetles; Rust-red grain beetle; Food mite; Stored grain pests, | |
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Stored gains - barley, wheat, oats, triticale; Non-cropped areas such as animal houses, domestic and industrial premises | |
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Efficiacy demonstrated via extensive use in the EU and field trials | |
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Current | |
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1973, first registration USA |
UK regulatory status |
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Approved | ||
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31/07/2029 | ||
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None |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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France | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Expired | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information |
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Australia, Morocco |
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Chemical structure |
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None | |
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C₁₁H₂₀N₃O₃PS | |
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CCN(CC)C1=NC(=CC(=N1)OP(=S)(OC)OC)C | |
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No data | |
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QHOQHJPRIBSPCY-UHFFFAOYSA-N | |
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InChI=1S/C11H20N3O3PS/c1-6-14(7-2)11-12-9(3)8-10(13-11)17-18(19,15-4)16-5/h8H,6-7H2,1-5H3 | |
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Yes |
General status |
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Insecticide, Acaricide | |
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Organophosphate insecticide; Organophosphate acaricide; Organothiophosphate insecticide; Organothiophosphate acaricide; Pyrimidine insecticide; Pyrimidine acaricide | |
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880 g kg⁻¹ | |
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EU dossier - various metabolites | |
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Synthetic | |
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Broad-spectrum with contact and respiratory action. Acetylcholinesterase (AChE) inhibitor. | |
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29232-93-7 | |
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249-528-5 | |
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239 | |
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108102 | |
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34526 | |
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015-134-00-5 | |
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305.33 | |
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- | |
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O-2-diethylamino-6-methylpyrimidin-4-yl O,O-dimethyl phosphorothioate | |
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O-(2-(diethylamino)-6-methyl-4-pyrimidinyl) O,O-dimethyl phosphorothioate | |
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PAN listed Highly Hazardous Chemical; Subject to the provisions of the UK Poisons Act 1972 | |
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UK non-statutory standard for the protection of aquatic life: freshwater and saltwater annual average; 0.015 µg l⁻¹; max acceptable conc: 0.05 µg l⁻¹ | |
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Not applicable | |
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Not applicable | |
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1B | |
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Not applicable | |
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Acarus chaetoxysilus, Acarus farris, Blattella germanica, Ephestia cautella, Meligethes aeneus, many others | |
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Clear to straw coloured liquid |
Formulations |
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Available in a variety of formulations including emulsifiable conentrates and smoke generators |
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11 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low | ||||||||
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250000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Xylene5 = Verified data used for regulatory purposes |
- | ||||||||
250000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Methanol5 = Verified data used for regulatory purposes |
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250000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Acetone5 = Verified data used for regulatory purposes |
- | |||||||||
250000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Ethyl acetate5 = Verified data used for regulatory purposes |
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20.8 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
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Decomposes before boiling | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
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162 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | ||||||||
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46 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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1.58 X 1004 | Calculated | - | |||||||
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4.2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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Soluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- | |||||||
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Regulatory data - observed in metabolism and farm animal feeding studies | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1.17 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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4.3 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Weak acid | |||||||||||
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2.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility. If applied directly to plants or soil, drift is a concern & mitigation is advisable | ||||||||
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0.06 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-volatile | ||||||||
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301nm = 3690, 270nm = 142000, 247nm = 22400, 220nm = 3390 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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58.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) at 21°C5 = Verified data used for regulatory purposes |
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Degradation |
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39 | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 4 = Verified data |
Moderately persistent | |||||||
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12 | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 4 = Verified data |
Non-persistent | ||||||||
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39 | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 4 = Verified data |
Moderately persistent | ||||||||
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Lab studies DT₅₀ range 3-21 days, field studies range 18-67 days | ||||||||||
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2.9 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Published literature RL₅₀ range 0.7-4.8 days, 2 undercover crops, various matrices, n=4 | ||||||||||
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2.2 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Published literature RL₅₀ range 1.7-3.1 days,2 field & undercover grown crops, various matrices, n=5; Maize grain in store RL₅₀=90.5 days | ||||||||||
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0.2 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Fast | |||||||
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117 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Persistent | |||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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[Wheat grain: 70 wks @ 30 DegC, 50% RH; Modelled data], [Wheat grain: >28 wks @ 25 DegC, 65% RH; Lab study], [Milled, toasted maize flour (gofio): 167 days @ dark, ambient conditions; Field study], [Milled, toasted wheat flour (gofio): 25 days @ dark, ambient conditions; Field study], [Corn grain: 34.7 days @ 20-25 DegC, 40-60% RH; Lab study], [Rice: 26.4 days @ -20 DegC; Lab study] |
Soil adsorption and mobility |
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- | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 4 = Verified data |
Slightly mobile | |||||||
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1100 | ||||||||||
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Fate indices |
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1.53 | Calculated | Low leachability | ||||||||||||||||||||||||||
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4.01 X 10-02 | Calculated | - | |||||||||||||||||||||||||
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Medium | Calculated | - | ||||||||||||||||||||||||||
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Slightly mobile | Calculated | - | ||||||||||||||||||||||||||
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741 | Q2 Q = Miscellaneous data from online sources Estimated2 = Unverified data of unknown source |
Threshold for concern | |||||||||||||||||||||||||
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Not available | - |
Known soil and groundwater metabolites |
None
Other known metabolites |
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2-diethylamino-4-hydroxy-6-methylpyrimidine (Ref: R046382) | - | Stored grain; Animal; Rat; Human (Urine); Plant | - | ||||
O-2-ethylamino-6-methylpyrimidin-4-yl O,O-dimethylphosphorothioate (Ref: R036341) | - | Stored grain | - | ||||
2-ethylamino-6-methyl-pyrimidin-4-ol (Ref: R035510) | - | Animal; Human (Urine); Plant | - | ||||
O-2-ethylamino-6-methylpyrimidin-4-yl O-methyl phosphorothioate | desethyl-R402186 | Animal | - | ||||
2-amino-4-hydroxy-6-methylpyrimidine (Ref: R004039) | - | Animal | - |
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Terrestrial ecotoxicology |
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1414 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Dog 12 wk5 = Verified data used for regulatory purposes |
High | |||||||
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> 1695 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Anas platyrhynchos5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.27 | K3 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) Apis mellifera3 = Unverified data of known source |
High | |||||||
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> 0.22 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Apis mellifera5 = Verified data used for regulatory purposes |
High | ||||||||
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Harmful | AA2 AA = IOBC Database on classification of side effects to beneficial organisms, 2005 Chrysoperla carnea2 = Unverified data of unknown source |
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Aquatic ecotoxicology |
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0.2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Oncorhynchus mykiss5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.023 | Q2 Q = Miscellaneous data from online sources Oncorhynchus mykiss2 = Unverified data of unknown source |
Moderate | ||||||||
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3.45 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio EC₅₀ Embryo3 = Unverified data of known source |
Moderate | ||||||||
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0.00021 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
High | ||||||||
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0.00008 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
High | ||||||||
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0.039 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Chironomus riparius 1 day3 = Unverified data of known source |
High | ||||||||
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1.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Raphidocelis subcapitata5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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1414 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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> 4.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat 4 hr (nose only)5 = Verified data used for regulatory purposes |
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0.004 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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0.15 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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No data | - | - | ||||||||
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0.02 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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25-75 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) concentration dependent5 = Verified data used for regulatory purposes |
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List I; List II | - | - | ||||||||
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Bystanders are unlikely to become exposed due to patterns of use | |||||||||
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PPE/PPC recommended | ||||||||||
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Health issues |
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May cause contact dermatitis |
Handling issues |
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Not explosive or oxidising IMDG Transport Hazard Class 9 |
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Health: H302 Environment: H400, H410 |
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II (Moderately hazardous) | |||
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UN3082 | |||
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Packaging Group III (minor danger) | |||
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Stable and non-reactive under normal conditions of use, storage and transport |
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pirimiphos-methyl | ||
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pyrimiphos-methyle | ||
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Pirimiphos-methyl | ||
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pirimiphos-methyl | ||
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pirimifos-metile | ||
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pirimifos-metil | ||
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pirimiphos-methyl | ||
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pirimifos metylu | ||
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pirimifosz-metil | ||
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pirimifos-methyl | ||
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Record last updated: | 22/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |