| Mesosulfuron (Ref: AE F154851) |
![]() Last updated: 07/02/2026 |
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(Also known as: mesosulfuron acid) |
| SUMMARY |
| Hazard alerts |
The following Pesticide Hazard Tricolour (PHT) alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. The alerts for Highly Hazardous Pesticides (HHPs) are based on applying the FAO/WHO (Type 1) and the PAN (Type II) criteria to PPDB data. Further details on the HHP indicators are given in the tables below. Neither the PHT nor the HHP hazard alerts take account of usage patterns or exposure, thus they do not represent risk.
| PHT: Environmental fate | PHT: Ecotoxicity | PHT: Human health | Highly Hazardous Pesticide |
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A herbicide, usually used as the methyl variant, for post-emergence control of grasses and weeds in cereals. Also a pesticide transformation product | |
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Grasses including blackgrass; Broadleaved weeds | |
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Cereals including spring wheat, winter wheat, durum wheat | |
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| GB regulatory status |
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Approved | ||
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30/06/2032 | ||
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Check label - may vary with formulation |
| EC Regulation 1107/2009 (repealing 91/414) |
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Approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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France/Poland | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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30/06/2032 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Additional information |
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| Chemical structure |
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None | |
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C₁₆H₁₉N₅O₉S₂ | |
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COC1=CC(=NC(=N1)NC(=O)NS(=O)(=O)C2=C(C=CC(=C2)CNS(=O)(=O)C)C(=O)O)OC | |
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MAYMYMXYWIVVOK-UHFFFAOYSA-N | |
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InChI=1S/C16H19N5O9S2/c1-29-12-7-13(30-2)19-15(18-12)20-16(24)21-32(27,28)11-6-9(8-17-31(3,25)26)4-5-10(11)14(22)23/h4-7,17H,8H2,1-3H3,(H,22,23)(H2,18,19,20,21,24) | |
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Yes |
| General status |
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Herbicide; Metabolite | ||||||||||||||
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Soil | ||||||||||||||
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Sulfonylurea herbicide; Pirimidinylsulfonylurea herbicide | ||||||||||||||
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930 g kg⁻¹ | ||||||||||||||
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EU dossier - None declared | ||||||||||||||
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Synthetic | ||||||||||||||
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Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS | ||||||||||||||
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400852-66-6 | ||||||||||||||
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609-783-9 | ||||||||||||||
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663 | ||||||||||||||
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- | ||||||||||||||
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11520759 | ||||||||||||||
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No data found | ||||||||||||||
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489.48 | ||||||||||||||
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2-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-4-(methanesulfonamidomethyl)benzoic acid | ||||||||||||||
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2-[(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-a-(methanesulfonamido)-p-toluic acid | ||||||||||||||
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2-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-4-[[(methylsulfonyl)amino]methyl]benzoic acid | ||||||||||||||
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Potential groundwater pollutant | ||||||||||||||
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B | ||||||||||||||
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2 | ||||||||||||||
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Not applicable | ||||||||||||||
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Not applicable | ||||||||||||||
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| Can be a metabolite of: |
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| mesosulfuron-methyl | Groundwater | - | Not relevant | |||||
| mesosulfuron-methyl | Soil | 0.162 | Major fraction |
| Commercial |
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Current | |||
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2004, first registration as methyl variant USA | |||
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Products normally use the methyl variant and are typically formulated as a water-dispersible granule | |||
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Mesosulfuron is synthesised through a multi-step organic process involving the coupling of a benzoic acid derivative with a dimethoxypyrimidinyl sulfonamide. | |||
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Insoluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Regulatory data | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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| Degradation |
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56.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately persistent | |||||||
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56.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately persistent | ||||||||
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39.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately persistent | ||||||||
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214.3 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Persistent | ||||||||
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186 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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EU 2016 dossier lab studies DT₅₀ range 18.7-148.9 days, DT₉₀ range 62.2-254.9 days, Soils=10; Field studies DT₅₀ range 4-100 days, DT₉₀ range 30-423 days | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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| Soil adsorption and mobility |
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1.55 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Mobile | |||||||
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68.3 | ||||||||||
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0.94 | ||||||||||
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EU dossier kf range 0.75-3.1 mL g⁻¹; Kfoc 46-98 mL g⁻¹; 1/n range 0.92-0.95; Soils=3 | ||||||||||
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| Fate indices |
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3.46 | Calculated | High leachability | ||||||||||||||||||||||||||
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5.19 X 10-01 | Calculated | - | |||||||||||||||||||||||||
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Mobile | Calculated | - | ||||||||||||||||||||||||||
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| Known metabolites |
None
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| Terrestrial ecotoxicology |
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> 5000 | Q3 Q = Miscellaneous data from online sources Rat as methyl variant3 = Unverified data of known source |
Low | ||||||||
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648 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Dog 90-day as methyl variant5 = Verified data used for regulatory purposes |
Low | ||||||||
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103 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Mouse 18-mnth5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 2000 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Anas platyrhynchos as methyl variant4 = Verified data |
Low | ||||||||
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93 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Colinus virginianus as methyl varaint NOEL4 = Verified data |
Moderate | ||||||||
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> 1000 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida4 = Verified data |
Low | ||||||||
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125.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida 56 day5 = Verified data used for regulatory purposes |
Low | ||||||||
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1000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Folsomia candida5 = Verified data used for regulatory purposes |
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> 13 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Moderate | |||||||
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> 5.6 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Moderate | ||||||||
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> 100 | R3 R = Peer reviewed scientific publications Bombus terrestris3 = Unverified data of known source |
Low | |||||||
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| Aquatic ecotoxicology |
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> 100 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Oncorhynchus mykiss as methyl variant 4 = Verified data |
Low | ||||||||
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95.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Pimephales promelas as methyl variant 32 day5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 100 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna as methyl variant4 = Verified data |
Low | ||||||||
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38 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Raphidocelis subcapitata5 = Verified data used for regulatory purposes |
Low | ||||||||
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| Regulatory Threshold Levels (RTLs) |
Note: These RTLs have been calculated using the regulatory approach used in the European Union and based on ecotoxocity values in the PPDB.
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20.6 | Worst case of acute and chronic mammals | |||
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18.6 | Worst case of acute and chronic birds | |||
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25 | Worst case of acute and chronic earthworms | |||
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No data | No data for non-target plants vegetative vigour and seedling emergence | |||
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0.112 | Worst case of contact and oral honeybees | |||
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No data | No data for parasitic wasps and predatory mites | |||
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1 | Worst case of temperate acute and chronic fish | |||
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1 | Worst case of temperate acute and chronic aquatic invertebrates | |||
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3.8 | Worst case of free-floating plants, rooted plants, acute and chronic algae |
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| General |
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High (class III) | - | - | ||||||||
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> 5000 | Q3 Q = Miscellaneous data from online sources Rat as methyl variant3 = Unverified data of known source |
Low | ||||||||
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648 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Dog 90-day as methyl variant5 = Verified data used for regulatory purposes |
Low | ||||||||
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103 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Mouse 18-mnth5 = Verified data used for regulatory purposes |
Low | ||||||||
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1.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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None allocated | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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0.13 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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| Health issues |
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No further information available | ||||||||||||||||||||||||||||
| Handling issues |
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No information available | |||
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Environment: H400, H410 | |||
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Not listed (Not listed) | |||
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mesosulfuron | ||
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mesosulfuron | ||
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Mesosulfuron | ||
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mesosulfuron | ||
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mesosulfuron | ||
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mesosulfuron | ||
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kwas mezosulfuronowy | ||
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mesosulfuron | ||
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| Record last updated: | 07/02/2026 |
| Contact: | aeru@herts.ac.uk |
| Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |
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