Orysastrobin is a rice fungicide. It has a moderate aqueous solubility, is volatile and, based on its chemical properties, is mobile and can be expected to leach to groundwater. It is generally moderately persistent in soil systems but will not usually persist in aquatic systems under certain conditions. It is not generally susceptible to hydrolysis. It has a moderate mammalian toxicity and has a high potential to bioaccumulate. It is moderately toxic to most aquatic species, birds and earthworms but relatively non-toxic to honeybees.
Hazard alerts
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate
Ecotoxicity
Human health
Environmental fate High alert: GUS: High leachability
Human health Moderate alert: Mammals acute toxicity: Moderate; Possible Carcinogen; Reproduction/development effects
Warning: Significant data are missing
GENERAL INFORMATION
Description
A rice fungicide that is highly effective against rice blast and other fungal pathogens.
Example pests controlled
Blast (Magnaporthe oryzae; Pyricularia oryzae); Root rot, damping off and blackleg (Thanatephorus cucumeris; Rhizoctonia solani)
Example applications
Rice
Efficacy & activity
-
GB regulatory status
GB COPR regulatory status
Not approved
Date COPR inclusion expires
Not applicable
GB LERAP status
No UK approval for use as a plant protection agent
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Not approved
Dossier rapporteur/co-rapporteur
Not applicable
Date EC 1107/2009 inclusion expires
Not applicable
EU Candidate for substitution (CfS)
Not applicable
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
 
 
 
 
 
 
 
 
 
Additional information
Also used in
Japan; South Korea
Chemical structure
Isomerism
Orysastrobin exhibits geometric (E/Z) isomerism due to the presence of multiple methoxyimino functional groups and conjugated double bonds in its molecular structure. Specifically, the compound contains four E/Z centres, which arise from the restricted rotation around its C=N and C=C bonds.
Example manufacturers & suppliers of products using this active now or historically
BASF
Example products using this active
Arashi
Formulation and application details
-
Commercial production
Orysastrobin is synthesised through a multi-step chemical process involving the construction of its complex heterocyclic structure. The synthesis typically begins with the formation of a methoxyimino intermediate, which is then coupled with a substituted benzene ring containing a dioxa-diazanonadiene moiety. This key intermediate undergoes further condensation with N-methylacetamide under controlled conditions to form the final active compound. The reaction sequence involves precise temperature control, solvent selection and purification steps such as crystallisation or chromatography to ensure high purity.
Impact on climate of production and use
Data for the amount of life cycle GHGs produced by orysastrobin are not available in the public domain. However, whilst estimates vary, more general data suggests that between 11 and 30 kilograms of CO₂e is emitted per kilogram of fungicide produced.
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
80.6
R4 R = Peer reviewed scientific publications 4 = Verified data
Moderate
Solubility - In organic solvents at 20 °C (mg l⁻¹)
206000
R4 R = Peer reviewed scientific publications 4 = Verified data
Ethyl acetate
-
590
R4 R = Peer reviewed scientific publications 4 = Verified data
n-Heptane
-
125000
R4 R = Peer reviewed scientific publications 4 = Verified data
Toluene
-
33900
R4 R = Peer reviewed scientific publications 4 = Verified data
Propanol
-
Melting point (°C)
99
R4 R = Peer reviewed scientific publications 4 = Verified data
-
Boiling point (°C)
-
-
-
Degradation point (°C)
-
-
-
Flashpoint (°C)
-
-
-
Octanol-water partition coefficient at pH 7, 20 °C
P
2.29 X 1002
Calculated
-
Log P
2.36
R4 R = Peer reviewed scientific publications 4 = Verified data
Low
Fat solubility of residues
Solubility
-
-
-
Data type
-
-
-
Density (g ml⁻¹)
-
-
-
Dissociation constant pKa) at 25 °C
-
-
-
-
Vapour pressure at 20 °C (mPa)
7.0 X 10-04
R4 R = Peer reviewed scientific publications 4 = Verified data
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
-
-
-
Volatilisation as max % of applied dose lost
From plant surface
-
-
-
From soil surface
-
-
-
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
-
-
-
Surface tension (mN m⁻¹)
-
-
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
55
R4 R = Peer reviewed scientific publications 4 = Verified data
Moderately persistent
DT₅₀ (lab at 20 °C)
-
-
-
DT₅₀ (field)
55
R4 R = Peer reviewed scientific publications 4 = Verified data
Moderately persistent
DT₉₀ (lab at 20 °C)
-
-
-
DT₉₀ (field)
-
-
-
DT₅₀ modelling endpoint
-
-
-
Note
Manufacturers published information gives DT₅₀ 51-58 days for field studies
Dissipation rate RL₅₀ (days) on plant matrix
Value
-
-
-
Note
-
Dissipation rate RL₅₀ (days) on and in plant matrix
Value
-
-
-
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
0.8
R4 R = Peer reviewed scientific publications 4 = Verified data
Fast
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
365
R4 R = Peer reviewed scientific publications 4 = Verified data
Very persistent
Note
-
Water-sediment DT₅₀ (days)
-
-
-
Water phase only DT₅₀ (days)
-
-
-
Sediment phase only DT₅₀ (days)
-
-
-
Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀
-
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd (mL g⁻¹)
-
R4 R = Peer reviewed scientific publications 4 = Verified data
Moderately mobile
Koc (mL g⁻¹)
92
Notes and range
Manufacturers published information gives Koc range 17.9-146 mL g⁻¹
Freundlich
Kf (mL g⁻¹)
-
-
-
Kfoc (mL g⁻¹)
-
1/n
-
Notes and range
-
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
3.54
Calculated
High leachability
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
6.25 X 10-01
Calculated
-
Note
-
Potential for particle bound transport index
Medium
Calculated
-
Potential for loss via drain flow
Moderately mobile
Calculated
-
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
-
-
-
Bio-concentration factor
BCF (l kg⁻¹)
Low risk
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Based on LogP < 3
Low risk
CT₅₀ (days)
-
-
Known metabolites
None
ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 356
R4 R = Peer reviewed scientific publications 4 = Verified data
Rat
Moderate
Mammals - Short term dietary NOEL
(mg kg⁻¹)
-
-
-
(ppm diet)
-
-
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
-
-
-
Birds - Acute LD₅₀ (mg kg⁻¹)
> 2000
R4 R = Peer reviewed scientific publications 4 = Verified data
Colinus virginianus
Low
Birds - Short term dietary (LC₅₀/LD₅₀)
-
-
-
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
-
-
-
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹ dw soil)
1000
R4 R = Peer reviewed scientific publications 4 = Verified data
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242