Chlorfenvinphos (Ref: OMS 166) |

Last updated: 23/08/2024
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(Also known as: clofenvinfos; CVP; OMS 1328; ENT 24969; CGA 26351) |
Chlorfenvinphos is a soil-applied insecticide. It has a moderate aqueous solubility and is miscible with many organic solvents. It is relatively volatile and there is some risk that it may leach to groundwater. It is moderately persistent in soil systems. It is highly toxic to mammals, an endocrine disrupter, a neurotoxin and an inhibitor of cholinesterase. In addition, there is some concern that it may bio-concentrate. Chlorfenvinphos is highly toxic to birds, honeybees and aquatic invertebrates. It is moderately toxic to fish and earthworms. |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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A soil applied insecticide used to control root-flies, rootworms and other soil pests. Also used as a sheep dip. |
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Ticks; Livestock flies; Mites; Root flies; Rootworms; Colorado beetle; Leafhoppers |
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Potatoes; Rice; Vegetables including brassicas, swedes, turnips, carrots, onions; Citrus; Sugarcane; Sweetcorn |
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- |
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Current |
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circa 1962, introduced |
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Not approved |
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Expired |
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No UK approval for use as a pesticide |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Germany |
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Expired |
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- |
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Yes |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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Australia, S. Africa, South & Central America, kenya |
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Exists in two geometric isomeric forms: alpha (cis) isomer and beta (trans) isomer. |
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C₁₂H₁₄Cl₃O₄P |
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CCOP(=O)(OCC)OC(=CCl)C1=C(C=C(C=C1)Cl)Cl |
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CCOP(=O)(OCC)O/C(=C\Cl)/C1=C(C=C(C=C1)Cl)Cl |
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FSAVDKDHPDSCTO-UHFFFAOYSA-N |
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InChI=1S/C12H14Cl3O4P/c1-3-17-20(16,18-4-2)19-12(8-13)10-6-5-9(14)7-11(10)15/h5-8H,3-4H2,1-2H3/b12-8- |
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Yes |
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Insecticide, Acaricide, Veterinary substance |
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Organophosphate insecticide; Organophosphate acaricide |
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- |
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- |
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Synthetic |
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Contact and stomach action. Acetylcholinesterase (AChE) inhibitor. |
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470-90-6 |
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207-432-0 |
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88 |
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084101 |
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5377784 |
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015-071-00-3 |
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359.6 |
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(1E)-2-chloro-1-(2,4-dichlorophenyl)ethenyl diethyl phosphate |
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(EZ)-2-chloro-1-(2,4-dichlorophenyl)vinyl diethyl phosphate |
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2-chloro-1-(2,4-dichlorophenyl)ethenyl diethyl phosphate |
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WFD priority substance; Marine, Surface and Groundwater Pollutant; Chemical subject to PIC regulations; PAN Bad Actor Chemical; Subject to the provisions of the UK Poisons Act 1972 |
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EU Directive 2008/105/EC EQS surface waters: annual average 0.1 µg l⁻¹; max measured 0.3 µg l⁻¹ |
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Not applicable |
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Not applicable |
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1B |
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Not applicable |
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Ceutorhynchus assimilis, Culex pipiens pipiens, Meligethes aeneus, Rhizoglyphus robini, Spodoptera litura, plus others |
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Colourless to amber liquid |
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- BASF
- Agro-Care
- Zagro Singapore Pte. Ltd.
- Kenogard
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- Vinylphate
- Birlane
- Steladone
- Supona
- Apachlor
- Haptarax
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Available in a variety of formulations including emulsifiable concentrates, granules, seed treatments and wettable powders. |
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145 |
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Moderate |
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Miscible |
Acetone |
- |
Miscible |
Ethanol |
- |
Miscible |
Xylene |
- |
Miscible |
Dichloromethane |
- |
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-20 |
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- |
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167 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
- |
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- |
- |
- |
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- |
- |
- |
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6.31 X 1003 |
Calculated |
- |
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3.8 |
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High |
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Soluble |
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- |
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Regulatory data - observed in metabolism and farm animal feeding studies |
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- |
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1.36 |
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- |
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- |
- |
- |
- |
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0.0014 |
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Low volatility |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
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40 |
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Moderately persistent |
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37 |
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Moderately persistent |
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30 |
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Moderately persistent |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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Lab studies DT₅₀ range 6-98 days, field study range 12-45 days; FAO state DT₅₀ 10-45 days |
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- |
- |
- |
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- |
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20.2 |
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
- |
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Lemon fruit, n=1 |
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- |
- |
- |
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- |
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125 |
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Persistent |
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pH and temperature sensitive: DT₅₀ 29 days at pH 1 and 38 °C, 17 days at pH 9 and 38 °C, 1.3 hours at pH 13 and 20 °C, (L3) |
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- |
- |
- |
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7 |
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Moderately fast |
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- |
- |
- |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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- |
Soil adsorption and mobility |
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- |
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Slightly mobile |
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680 |
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Other literature data Koc 295 mL g⁻¹ (R4) |
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- |
- |
- |
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- |
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- |
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- |
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- |
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1.72 |
Calculated |
Low leachability |
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5.04 X 10-02 |
Calculated |
- |
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- |
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Low |
Calculated |
- |
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Slightly mobile |
Calculated |
- |
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- |
- |
- |
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250 |
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Threshold for concern |
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Not available |
- |
None
Terrestrial ecotoxicology |
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12 |
Rat |
High |
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- |
Rat |
- |
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3 |
- |
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- |
- |
- |
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80 |
Colinus virginianus |
High |
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- |
- |
- |
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- |
- |
- |
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130 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Moderate |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
- |
- |
- |
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4.1 |
Apis mellifera |
Moderate |
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0.55 |
Apis mellifera |
High |
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- |
- |
- |
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- |
- |
- |
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- |
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- |
- |
- |
- |
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- |
- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
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- |
- |
- |
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- |
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- |
- |
- |
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Harmless |
AA2 AA = IOBC Database on classification of side effects to beneficial organisms, 2005 2 = Unverified data of unknown source Chrysoperla carnea |
- |
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- |
- |
- |
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Harmful |
AA2 AA = IOBC Database on classification of side effects to beneficial organisms, 2005 2 = Unverified data of unknown source Typhlodromus pyri |
- |
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- |
- |
- |
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1.1 |
Oncorhynchus mykiss |
Moderate |
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0.03 |
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source Unknown species |
Moderate |
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- |
- |
- |
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0.00025 |
Daphnia magna |
High |
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0.0001 |
P3 P = Other non-EU, UK or US Governments and Regulators 3 = Unverified data of known source Daphnia magna |
High |
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> 0.0003 |
Ceriodaphnia dubia LC₅₀ |
High |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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1.36 |
Scenedesmus subspicatus |
Moderate |
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1 |
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source Unknown species |
Moderate |
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- |
- |
- |
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- |
- |
- |
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- |
- |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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- |
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12 |
Rat |
High |
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31 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Rabbit |
- |
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0.05 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Rat |
- |
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Intraperitoneal LD₅₀ = 87.0 mg kg⁻¹ |
Mouse |
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Intravenous LD₅₀ = 87.0 mg kg⁻¹ |
Mouse |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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- |
- |
- |
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List I; List II |
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- |
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- |
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Dermal and inhalation during pesticide handling Source: US EPA |
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EU MRL pesticide database |
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- |
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- |
- |
- |
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- |
- |
- |
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Majority excreted in the urine, much less in the faeces. Some also lost from the lungs. |
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- |
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Carcinogen |
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Endocrine disruptor |
No data found |
A3 A = Chromosome aberration (EFSA database) 3 = Negative ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
✓Yes, known to cause a problem |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
✓Yes, known to cause a problem |
✓Yes, known to cause a problem |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
No data found |
No data found |
Eye irritant |
Phototoxicant |
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No data found |
No data found |
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May cause bradycardia or tachycardia May cause Loss of muscle coordination, slurring of speech May cause mental confusion, disorientation and drowsiness Endocrine issues - Weak estrogen effect |
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Prevent generation of mists Not expected to auto-ignite; Not highly flammable IMDG Transport Hazard Class 6.1 |
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Health: H300, H311 Environment: H400, H410 |
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Ib (Highly hazardous) |
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UN3018 |
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- |
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- |
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chlorfenvinphos |
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chlorfenviphos |
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Chlorfenvinphos |
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chlorfenvinphos |
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clorfenvinfos |
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clorfenvinfos |
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chlorfenvinphos |
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chlorfenwinfos |
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klorfenvinfos |
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- |
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chloorfenvinfos |
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- |
Record last updated: |
23/08/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |