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Cloquintocet-mexyl (Ref: CGA 185072)
Last updated: 26/07/2026
(Also known as: cloquintocet mexyl)
SUMMARY
Hazard alerts

The following Pesticide Hazard Tricolour (PHT) alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. The alerts for Highly Hazardous Pesticides (HHPs) are based on applying the FAO/WHO (Type 1) and the PAN (Type II) criteria to PPDB data. Further details on the HHP indicators are given in the tables below. Neither the PHT nor the HHP hazard alerts take account of usage patterns or exposure, thus they do not represent risk.

PHT: Environmental fate PHT: Ecotoxicity PHT: Human health Highly Hazardous Pesticide
Environmental fate
Moderate alert:
Potential for particle bound transport: Medium
Ecotoxicity
Moderate alert:
Fish acute ecotoxicity: Moderate; Fish chronic ecotoxicity: Moderate
Human health
Moderate alert:
Mammals chronic toxicity: Moderate
  
GENERAL INFORMATION
Description
A herbicide safener used to improve cereal crop tolerance to herbicides particularly clodinafop-propargyl
Example pests/issues controlled
Crop damage from the herbicide
Example applications
Wheat; Barley
Efficacy & activity
-
GB regulatory status
GB COPR regulatory status
Approved
Date COPR inclusion expires
31/12/2030
GB LERAP status
Not applicable
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Not approved
Dossier rapporteur/co-rapporteur
Not applicable
Date EC 1107/2009 inclusion expires
Not applicable
EU Candidate for substitution (CfS)
Not applicable
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
                 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
                 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
                 
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
                 
Additional information
Also used in
Australia; Morocco
Chemical structure
Isomerism
The parent substance cloquintocet is achiral but the -mexyl ester is chiral.
Chemical formula
C₁₈H₂₂ClNO₃
Canonical SMILES
CCCCCC(C)OC(=O)COC1=C2C(=C(C=C1)Cl)C=CC=N2
Isomeric SMILES
-
International Chemical Identifier key (InChIKey)
COYBRKAVBMYYSF-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C18H22ClNO3/c1-3-4-5-7-13(2)23-17(21)12-22-16-10-9-15(19)14-8-6-11-20-18(14)16/h6,8-11,13H,3-5,7,12H2,1-2H3
2D structure diagram/image available?
Yes
General status
Pesticide type
Other substance; Herbicide
Other bioactivity & uses
Herbicide safener
Substance groups
Unclassified substance; Safener
Minimum active substance purity
-
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
Accelerates the herbicide detoxification process
CAS RN
99607-70-2
EC number
619-447-3
CIPAC number
-
US EPA chemical code
700099
PubChem CID
-
Molecular mass (Da)
335.8
PIN (Preferred Identification Name)
rac-(2R)-heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate
IUPAC name
(RS)-1-methylhexyl (5-chloroquinolin-8-yloxy)acetate
CAS name
1-methylhexyl [(5-chloro-8-quinolinyl)oxy]acetate
Global Governance status: Listed (✓) under
UK Poisons List Order 1972 Rotterdam Convention Montreal Protocol
XNo
The Poisons List Order 1972
XNo
Rotterdam Convention
XNo
Montreal Protocol
Stockholm Convention OSPAR EU Water Framework Directive
XNo
Stockholm Convention
XNo
OSPAR
XNo
EU Water Framework Directive
Relevant Environmental Water Quality Standards
-
Forever chemical
-
Highly Hazardous Pesticide (HHP)
Type I
-
Type II
-
Other status information
-
Herbicide Resistance Class (HRAC MoA class)
Not applicable
Herbicide Resistance Class (WSSA MoA class)
Not applicable
Insecticide Resistance Class (IRAC MoA class)
Not applicable
Fungicide Resistance Class (FRAC MOA class)
Not applicable
Examples of recorded resistance
-
Physical state
Colourless crystals
Related substances & organisms
Commercial
Property
Value
Availability status
Current
Introduction & key dates
1990, introduced
Example manufacturers & suppliers of products using this active now or historically
  • Conquest Crop Protection Pty Ltd
  • Corteva AgriScience
  • Nufarm
  • Sharda Agrochem Ltd
  • Syngenta AG
  • Yifan Biotech
Example products using this active
 
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Selected: Epic (Open in PFC)
   
Selected: Foxtrot EW (Open in PFC)
   
Selected: Fraxial (Open in PFC)
   
Selected: Fundatis (Open in PFC)
   
Selected: Glaive 100 EC (Open in PFC)
   
Selected: Glodiac (Open in PFC)
   
Selected: Grandstand (Open in PFC)
   
Selected: Kanaster (Open in PFC)
   
Selected: Lutimor (Open in PFC)
   
Selected: Manhattan (Open in PFC)
   
Selected: Materra (Open in PFC)
   
Selected: Memphis (Open in PFC)
   
Selected: Novax (Open in PFC)
   
Selected: Olupal (Open in PFC)
   
Selected: Orbit (Open in PFC)
   
Selected: Oskar (Open in PFC)
   
Selected: Palio (Open in PFC)
   
Selected: Pixxaro (Open in PFC)
   
Selected: Reata (Open in PFC)
   
Selected: Rexade Arylex (Open in PFC)
   
Selected: Scintilla (Open in PFC)
   
Selected: Topik (Open in PFC)
   
Selected: Tremis (Open in PFC)
   
Selected: Viscount (Open in PFC)
   
Selected: Whorl (Open in PFC)
   
Selected: Zypar (Open in PFC)
 
Formulation and application details
Usually supplied as an emulsifiable concentrate or incorporated into granular formulations
Commercial production
Cloquintocet-mexyl is commercially produced through a multi-step synthesis starting with 5-chloro-8-hydroxyquinoline as the primary raw material. The process begins with a nucleophilic substitution reaction where 5-chloro-8-hydroxyquinoline reacts with methyl chloroacetate in a solvent such as dimethylformamide, using potassium carbonate or a combination of sodium carbonate and sodium hydroxide as the base to form the intermediate methyl (5-chloro-8-quinolyloxy)acetate, typically at elevated temperatures to drive the alkylation at the 8-position oxygen. This ester is then subjected to alkaline hydrolysis with sodium hydroxide, followed by acidification (e.g., with hydrochloric acid) to yield the free acid, (5-chloro-8-quinolyloxy)acetic acid, which is isolated in high purity to minimize impurities. Finally, the acid undergoes esterification with 2-heptanol in the presence of an acid catalyst like sulfuric acid or p-toluenesulfonic acid, often under Dean-Stark azeotropic distillation conditions to remove water and shift equilibrium, producing cloquintocet-mexyl. An alternative direct transesterification route bypasses hydrolysis by reacting the methyl ester with 2-heptanol under similar catalytic conditions but may suffer lower yields due to equilibrium limitations and potential decomposition above 60DegC.
Impact on climate of production and use
-
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C at pH 7 (mg l⁻¹)
0.59
B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here )
5 = Verified data used for regulatory purposes
 Low
Solubility - In organic solvents at 20 °C (mg l⁻¹)
320000
C4 C = AGRITOX dataset. Dataset is no longer available.
4 = Verified data
Acetone		 -
9000
C4 C = AGRITOX dataset. Dataset is no longer available.
4 = Verified data
Hexane		 -
310000
C4 C = AGRITOX dataset. Dataset is no longer available.
4 = Verified data
Methanol		 -
320000
C4 C = AGRITOX dataset. Dataset is no longer available.
4 = Verified data
Toluene		 -
Melting point (°C)
69.4
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
 -
Boiling point (°C)
275
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
 -
Degradation point (°C)
- - -
Flashpoint (°C)
196
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
(closed cup)		 -
Octanol-water partition coefficient at pH 7, 20 °C
P
1.58 X 1005 Calculated -
Log P
5.20
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
 High
Fat solubility of residues
Solubility
- - -
Data type
- - -
Density (g ml⁻¹)
1.05
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
 -
Dissociation constant pKa) at 25 °C
3.75
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
 -
Weak base
Vapour pressure at 20 °C (mPa)
5.31 X 10-03
B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here )
5 = Verified data used for regulatory purposes
at 25 °C		 Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
3.02 X 10-03
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
 Non-volatile
Volatilisation as max % of applied dose lost
From plant surface
- - -
From soil surface
- - -
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
- - -
Surface tension (mN m⁻¹)
57
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
 -
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (Dark aerobic conditions)
DT₅₀ (typical)
5
W4 W = French database provided by ARVALIS-Institut du Végétal. Dataset no longer available.
4 = Verified data
 Non-persistent
DT₅₀ (lab at 20 °C)
1.75
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
 Non-persistent
DT₅₀ (field)
- - -
DT₉₀ (lab at 20 °C)
- - -
DT₉₀ (field)
- - -
DT₅₀ modelling endpoint
- - -
Note
ECHA: DT₅₀ 2.4 days loamy sand, 1.1 days sandy loam
Soil mineralisation
Aerobic (at 20 °C)
- - -
Anaerobic (at 20 °C)
- -
Dissipation rate RL₅₀ (days) on plant matrix
Value
- - -
Note
-
Dissipation rate RL₅₀ (days) on and in plant matrix
Value
- - -
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
3
Q3 Q = Miscellaneous data from online sources
3 = Unverified data of known source
 Moderately fast
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
139
C4 C = AGRITOX dataset. Dataset is no longer available.
4 = Verified data
 Persistent
Note
Stable acid and neutral media, hydrolysed under alkaline conditions
Water-sediment DT₅₀ (days)
- - -
Water phase only DT₅₀ (days)
- - -
Sediment phase only DT₅₀ (days)
- - -
Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀
-
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd (mL g⁻¹)
-
W3 W = French database provided by ARVALIS-Institut du Végétal. Dataset no longer available.
3 = Unverified data of known source
 Non-mobile
Koc (mL g⁻¹)
9856
Notes and range
Best available data
Freundlich
Kf (mL g⁻¹)
- - -
Kfoc (mL g⁻¹)
-
1/n
-
Notes and range
-
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
0.00 Calculated Low leachability
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
2.55 X 10-04 Calculated -
Note
-
Potential for particle bound transport index
Medium Calculated -
Potential for loss via drain flow
Non-mobile Calculated -
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
- - -
Bio-concentration factor
BCF (l kg⁻¹)
621
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Whole fish		 Threshold for concern
CT₅₀ (days)
4.0 -
Known metabolites

None

ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 2000
B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here )
5 = Verified data used for regulatory purposes
Rat		 Low
Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)
> 9.7
B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here )
4 = Verified data
Rat		 Moderate
Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)
- - -
Birds - Acute LD₅₀ (mg kg⁻¹)
> 2000
B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here )
5 = Verified data used for regulatory purposes
Colinus virginianus		 Low
Birds - Short term dietary LC₅₀ (mg kg⁻¹ bw d⁻¹)
> 1000
Q3 Q = Miscellaneous data from online sources
3 = Unverified data of known source
Anas platyrhynchos		 -
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
- - -
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹ dw soil)
> 1000
B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here )
5 = Verified data used for regulatory purposes
 Low
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹ dw soil)
> 500
Q3 Q = Miscellaneous data from online sources
3 = Unverified data of known source
 Low
Soil micro-organisms
- - -
Collembola
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
- - -
Non-target plants
Vegetative vigour ER₅₀ (g ha⁻¹)
- - -
Seedling emergence ER₅₀ (g ha⁻¹)
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 100
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Apis mellifera		 Low
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 100
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Apis mellifera		 Low
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Chronic
- - -
Notes
-
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other bee species (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other bee species (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Beneficial insects (Ladybirds)
- - -
Beneficial insects (Lacewings)
- - -
Beneficial insects (Parasitic wasps)
- - -
Beneficial insects (Predatory mites)
- - -
Beneficial insects (Ground beetles)
- - -
Beneficial insects (Butterflies)
Contact
- - -
Notes
-
Oral
- - -
Notes
-
Aquatic ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
> 14
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Ictalurus punctatus		 Moderate
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)
> 8.3
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Lepomis macrochirus		 Moderate
Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
> 100
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Daphnia magna		 Low
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
32
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Daphnia magna		 Low
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
> 50
P3 P = Other non-EU, UK or US Governments and Regulators
3 = Unverified data of known source
Chironomus riparius		 Low
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l⁻¹) (EC₅₀)
11.0
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Lemna gibba		 Low
Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l⁻¹)
- - -
Algae - Acute (growth rate, fresh; mg l⁻¹) (EC₅₀)
0.53
B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here )
4 = Verified data
Desmodesmus subspicatus		 Moderate
Algae - Chronic (growth rate, fresh; mg l⁻¹)
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
Marine bivalves
- - -
Regulatory Threshold Levels (RTLs)

Note: These RTLs have been calculated using the regulatory approach used in the European Union and based on ecotoxocity values in the PPDB.

Species group
RTL
Notes
Mammals
1.94 Worst case of acute and chronic mammals
Birds
200 Worst case of acute and chronic birds
Soil organisms
100 Worst case of acute and chronic earthworms
Terrestrial plants
No data No data for non-target plants vegetative vigour and seedling emergence
Pollinators
2 Worst case of contact and oral honeybees
Arthropods
No data No data for parasitic wasps and predatory mites
Fish
0.14 Worst case of temperate acute and chronic fish
Aquatic invertebrates
1 Worst case of temperate acute and chronic aquatic invertebrates
Aquatic plants
0.053 Worst case of free-floating plants, rooted plants, acute and chronic algae
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 2000
B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here )
5 = Verified data used for regulatory purposes
Rat		 Low
Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)
> 9.7
B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here )
4 = Verified data
Rat		 Moderate
Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)
- - -
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
> 2000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat		 -
Mammals - Inhalation LC₅₀ (mg l⁻¹)
> 0.935
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat		 -
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.04
B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here )
4 = Verified data
UK ACP 1999		 -
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
- - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
- - -
Dermal penetration studies (%)
- - -
Dangerous Substances Directive 76/464
- - -
Exposure Routes
Public
-
Occupational
-
MRLs
European
EU MRL pesticide database 
Great Britain
GB MRL Register 
Notes
-
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Mammalian dose elimination route and rate
- - -
Health issues
Specific human health issues (hazard-based)
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A3 A = Chromosome aberration (EFSA database)
3 = Negative
;
B3 B = DNA damage/repair (EFSA database)
3 = Negative
;
C3 C = Gene mutation (EFSA database)
3 = Negative
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E0 E = Unspecified genotoxicity type (miscellaneous data source)
0 = No data
 No data found
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
No data found
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
No data found
✓Yes, known to cause a problem
✓Yes, known to cause a problem
Eye irritant Phototoxicant  
✓Yes, known to cause a problem
 No data found  
General human health issues
Possible liver toxicant
Handling issues
Property
Value and interpretation
General
Not explosive or oxidising
CLP classification 2013
Health: H317, H319, H332, H373
Environment: H400, H410
WHO Classification
Not listed
UN Number
-
Waste disposal & packaging
-
Shelf-life, storage, stability and reactivity
-
TRANSLATIONS
Language
Name
English
cloquintocet-mexyl
French
cloquintocet-mexyl
German
Cloquintocet-mexyl
Danish
cloquintocet-mexyl
Italian
cloquintocet-mexyl
Spanish
cloquintocet-mexil
Greek
-
Polish
klokwintocet meksylowy
Swedish
-
Hungarian
-
Dutch
-
Norwegian
-
Record last updated: 26/07/2026
Contact: aeru@herts.ac.uk
Please cite as:

Tzilivakis, J., Lewis, K.A., Green, A. and Warner, D.J. (2026) A decade of growth and impact of the Pesticide Properties Database (PPDB). Human and Ecological Risk Assessment: An International Journal, 1–26. DOI: 10.1080/10807039.2026.2702066

Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242

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