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Dimethenamid-P
Last updated: 22/08/2024
(Also known as: dimethenamide-P; (S)-dimethenamid)

SUMMARY
Dimethanamid-P is a soil-applied herbicide. It is highly soluble in water and has a low volatility. It is not expected to be persistent in soil systems but may be persistent in water depending on local conditions. It is moderately toxic to birds, fish, aquatic invertebrates and algae but more so to aquatic plants. It is also moderately toxic to earthworms whilst its honeybee toxicity is low. Dimethenamid-P is also moderately toxic to mammals if ingested and is a skin and eye irritant, and a skin sensitizer.
Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate Ecotoxicity Human health
Environmental fate
Moderate alert:
GUS: Transition state; Drainflow: Moderately mobile
Ecotoxicity
Moderate alert:
Birds acute ecotoxicity: Moderate; Birds chronic ecotoxicity: Moderate; Fish acute ecotoxicity: Moderate; Fish chronic ecotoxicity: Moderate; Daphnia acute ecotoxicity: Moderate; Daphnia chronic ecotoxicity: Moderate; Earthworms acute ecotoxicity: Moderate; Earthworms chronic ecotoxicity: Moderate
Human health
Moderate alert:
Mammals acute toxicity: Moderate; Mammals chronic toxicity: Moderate; Reproduction/development effects
GENERAL INFORMATION
Description
A pre-emergence herbicide often used to control annual grasses, annual broad-leaved weeds and sedges
Example pests controlled
Black grass; Chickweed; Cleavers; Mayweed; Forget-me-not; Speedwell; Shepherd's purse; Cranes-bill
Example applications
Soybeans; Vegetables including beans, onions, cabbage; Peanuts; Grapevines; Ornamentals; Sugarbeet; Sunflowers; Stone fruit
Efficacy & activity
-
Availability status
Current
Introduction & key dates
1999, registered USA; 2000, registered UK
GB regulatory status
GB COPR regulatory status
Approved
Date COPR inclusion expires
31/08/2034
GB LERAP status
Possible - check label
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Approved
Dossier rapporteur/co-rapporteur
Germany/Bulgaria
Date EC 1107/2009 inclusion expires
31/08/2034
EU Candidate for substitution (CfS)
No
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
                 
Additional information
Also used in
Australia, Morocco
Chemical structure
Isomerism
Dimethenamid-P is the more biologically active isomer of chiral dimethenamid and is used at lower rates.
Chemical formula
C₁₂H₁₈ClNO₂S
Canonical SMILES
CC1=CSC(=C1N(C(C)COC)C(=O)CCl)C
Isomeric SMILES
CC1=CSC(=C1N([C@@H](C)COC)C(=O)CCl)C
International Chemical Identifier key (InChIKey)
JLYFCTQDENRSOL-VIFPVBQESA-N
International Chemical Identifier (InChI)
InChI=1S/C12H18ClNO2S/c1-8-7-17-10(3)12(8)14(11(15)5-13)9(2)6-16-4/h7,9H,5-6H2,1-4H3/t9-/m0/s1
2D structure diagram/image available?
Yes
General status
Pesticide type
Herbicide
Substance groups
Chloroacetamide herbicide; Amide herbicide
Minimum active substance purity
930 g kg⁻¹
Known relevant impurities
EU dossier - 1,1,1,2-tetrachloroethane <1.0 g kg⁻¹; 2,4-dimethylthiopene-3-ol <=1.5 g kg⁻¹
Substance origin
Synthetic
Mode of action
Selective. Inhibition of very long chain fatty acids (VLCFA, inhibition of cell division)
CAS RN
163515-14-8
EC number
605-329-9
CIPAC number
638
US EPA chemical code
129501
PubChem CID
13633097
CLP index number
616-215-00-3
Molecular mass
275.8
PIN (Preferred Identification Name)
2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide
IUPAC name
(S)-2-chloro-N-(2,4-dimethyl-3-thienyl)-N-(2-methoxy-1-methylethyl)acetamide
CAS name
2-chloro-N-(2,4-dimethyl-3-thienyl)-N-[(1S)-2-methoxy-1-methylethyl]acetamide
Other status information
-
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Class (HRAC MoA class)
K3
Herbicide Resistance Class (WSSA MoA class)
15
Insecticide Resistance Class (IRAC MoA class)
Not applicable
Fungicide Resistance Class (FRAC MOA class)
Not applicable
Examples of recorded resistance
-
Physical state
Yellow-brown viscous liquid
Related substances & organisms
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
Example products using this active
  • Elk
  • Shadow
  • Springbok
  • Frontier X-2
Formulation and application details
-
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
1499
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
High
Solubility - In organic solvents at 20 °C (mg l⁻¹)
310000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
n-Hexane
-
310000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
n-Heptane
-
1000000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Toluene
-
1000000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Acetone
-
Melting point (°C)
Solidification below -50
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Boiling point (°C)
280
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Degradation point (°C)
101
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
7.76 X 1001 Calculated -
Log P
1.89
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Low
Fat solubility of residues
Solubility
- - -
Data type
- - -
Density (g ml⁻¹)
1.2
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Dissociation constant pKa) at 25 °C
Not applicable
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
No dissociation
Vapour pressure at 20 °C (mPa)
3.47
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Low volatility. If applied directly to plants or soil, drift is a concern & mitigation is advisable
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
4.80 X 10-04
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-volatile
Volatilisation as max % of applied dose lost
From plant surface
26.1
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
24 hr
Volatilisation is potentially a concern for short and long range air transport
From soil surface
-
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
24 hr
-
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
236nm = 7560
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Surface tension (mN m⁻¹)
52.0
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
at 20 °C 0.1%w/w
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
11
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-persistent
DT₅₀ (lab at 20 °C)
12.1
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-persistent
DT₅₀ (field)
15.8
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-persistent
DT₉₀ (lab at 20 °C)
44.6
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderately persistent
DT₉₀ (field)
70.1
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
DT₅₀ modelling endpoint
- - -
Note
EU dossier Lab studies DT₅₀ range 5-31 days (normalised), DT₉₀ range 26-104 days, field studies DT₅₀ range 10-20 days (normalised), DT₉₀ range 48-167 days (normalised)
Dissipation rate RL₅₀ (days) on plant matrix
Value
- - -
Note
-
Dissipation rate RL₅₀ (days) on and in plant matrix
Value
- - -
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
13.7
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderately fast
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
Stable
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Stable
Note
Stable pH 5 to pH 9 over 30 days, 25 °C
Water-sediment DT₅₀ (days)
28
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Fast
Water phase only DT₅₀ (days)
24
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Slow
Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀
-
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd (mL g⁻¹)
- - -
Koc (mL g⁻¹)
-
Notes and range
-
Freundlich
Kf (mL g⁻¹)
3.69
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderately mobile
Kfoc (mL g⁻¹)
227
1/n
1.0
Notes and range
EU dossier Kf range 1.23-13.5 mL g⁻¹, Kfoc range 90-474 mL g⁻¹, 1/n range 0.92 -1.07, Soils=10
pH sensitivity
No
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
1.97 Calculated Transition state
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
5.49 X 10-02 Calculated -
Note
-
Potential for particle bound transport index
Low Calculated -
Potential for loss via drain flow
Moderately mobile Calculated -
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
4.8
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Calculated using the Atkinson method. Assumed 1.5E+06 OH/cm³, 12 hr
Below the level of concern for long-range air transport
Bio-concentration factor
BCF (l kg⁻¹)
Low risk
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Based on LogP < 3
Low risk
CT₅₀ (days)
- -
Known soil metabolites
Metabolite
Major/Minor fraction
Estimated maximum occurrence fraction
Notes
2-((2,4-dimethyl-3-thienyl)-((1S)-2-methoxy-1-methyl-ethyl)amino)-2-oxo-acetic acid (Ref: M656PH023)
Major fraction 0.134 BASF verified
2-((2,4-dimethyl-3-thienyl)-((1S)-2-methoxy-1-methyl-ethyl)amino)-2-oxo-ethanesulfonic (Ref: M656PH027)
Major fraction 0.133 BASF verified
2-(2-((2,4-dimethyl-3-thienyl)-((1S)-2-methoxy-1-methyl-ethyl)amino)-2-oxo-ethylsulfinylacetic acid (Ref: M656PH031)
Major fraction 0.103 BASF verified
Known groundwater metabolites
Metabolite
EC SANCO/221/2000 relevancy
ADI (mg kg⁻¹ bodyweight day⁻¹)
WHO drinking water guidance value (μg L⁻¹ day⁻¹)
2-((2,4-dimethyl-3-thienyl)-((1S)-2-methoxy-1-methyl-ethyl)amino)-2-oxo-ethanesulfonic (Ref: M656PH027)
Not relevant 0.34 2040
N-(2,4-dimethyl-3-thienyl)-N-[(1S)-2-methoxy-1-methyl-ethyl]-2-methylsulfonyl-acetamide (Ref: M656PH010)
Not relevant - -
2-(2-((2,4-dimethyl-3-thienyl)-((1S)-2-methoxy-1-methyl-ethyl)amino)-2-oxo-ethylsulfinylacetic acid (Ref: M656PH031)
Not relevant 1.0 6000
2-[2-[(2,4-dimethyl-3-thienyl)-[(1S)-2-methoxy-1-methyl-ethyl]amino]-2-oxo-ethyl]sulfanylacetic acid (Ref: M656PH032)
Not relevant 0.04 240
2-[2-[(2,4-dimethyl-3-thienyl)-[(1S)-2-methoxy-1-methyl-ethyl]amino]-2-oxo-ethyl]sulfonyl acetic acid (Ref: M656PH051)
Not relevant - -
3-{(hydroxyacetyl)[(2S)-1-methoxypropan-2-yl]amino}-4-methylthiophene-2-carboxylic acid (Ref: M656PH043)
Not relevant - -
N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide (Ref: M656PH003)
Not relevant 0.04 240
(2S)-2-[(2,4-dimethyl-3-thienyl)-(2-sulfoacetyl)amino]propanoic acid (Ref: M656PH054)
Not relevant 0.35 2100
(E)-3-[[(1S)-2-methoxy-1-methyl-ethyl]-(2-sulfoacetyl)amino]-2-methyl-4-oxo-pent-2-enoic acid (Ref: M656PH052)
Not relevant - -
2-[[4-(hydroxymethyl)-2-methylene-5-oxo-3-thienyl]-[(1S)-2-methoxy-1-methyl-ethyl]amino]-2-oxo-ethanesulfonic acid (Ref: M656PH053)
Not relevant - -
2-[(2,4-dimethyl-3-thienyl)amino]-2-oxo-ethanesulfonic acid (Ref: M656PH055)
Not relevant - -
2-[[(1S)-2-methoxy-1-methyl-ethyl]-(4-methyl-2-methylene-5-oxo-3-thienyl)amino]-2-oxo-ethanesulfonic acid (Ref: M656PH059)
Not relevant - -
3-[[(1S)-2-methoxy-1-methyl-ethyl]amino]-4-methyl-thiophene-2-carboxylic acid (Ref: M656PH062)
Not relevant 0.1 600
2-((2,4-dimethyl-3-thienyl)-((1S)-2-methoxy-1-methyl-ethyl)amino)-2-oxo-acetic acid (Ref: M656PH023)
Not relevant 0.36 2160
3-[((1S)-2-methoxy-1-methyl-ethyl)-oxalo-amino]-acid (Ref: M656PH045)
Not relevant 1.17 7020
(E)-3-[[(1S)-2-methoxy-1-methyl-ethyl]-oxalo-amino]-2-methyl-4-oxo-pent-2-enoic acid (Ref: M656PH049)
Not relevant - -
2-[(2,4-dimethyl-3-thienyl)-[(1S)-2-hydroxy-1-methyl-ethyl]amino]-2-oxo-acetic acid (Ref: M656PH050)
Not relevant - -
3-{[(2S)-1-methoxypropan-2-yl](sulfoacetyl)amino}-4-methylthiophene-2-carboxylic acid (Ref: M656PH047)
Not relevant 0.97 5820
Other known metabolites
Metabolite name and reference
Aliases
Formation medium / Rate
Estimated maximum occurrence fraction
3,4-dihydro-4-(2,4-dimethyl-3-thienyl)-5-methyl-2H-1,4-oxazin-3-one - - -
4-(2,4-dimethyl-3-thienyl)-5-methyl-3-morpholinone - - -
N-(2,4-dimethyl-3-thienyl)-N-(2-methoxy-1-methylethyl)-2-(methylsulfonyl)acetamide - Rat -
N-(2,4-dimethyl-3-thienyl)-2-hydroxy-N-(2-methoxy-1-methylethyl)acetamide - - -
N-(2,4-dimethyl-3-thienyl)-N-(2-hydroxy-1-methylethyl)acetamide - - -
N-(2,4-dimethyl-3-thienyl)-N-(2-methoxy-1-methylethyl)-2-(methylsulfinyl)acetamide - Rat -
methylated N-(2,4-dimethyl-3-thienyl)-N-((methylsulfonyl)acetyl)alanine - Rat -
1,5-dihydro-1-(2-methoxy-1-methylethyl)- 8-methylthieno-[thieno-[3,4-f][4,1]oxazepin-2(3H)-one - Rat -
4-(2,4-dimethyl-3-thienyl)-6-hydroxy-5-methyl-3-thiomorpholinone - Rat -
2,2'-dithiobis(N-(2,4-dimethyl-3-thienyl)-N-(2-methoxy-1-methylethyl)acetamide) - Rat -
2-[N-(2,4-dimethyl-3-thienyl)-N- (2-methoxy-1-methylethyl)amino]-2-oxoethyl-glutathione glutathione conj Rat -
2-[N-(2,4-dimethyl-3-thienyl)-N- (2-methoxy-1-methylethyl)amino]-2-oxoethyl-cysteine - Rat; Plant -
2-[N-(2,4-dimethyl-3-thienyl)-N-(2-methoxy-1-methylethyl)amino]-2-oxoethyl-thiolactic acid thiolactic acid conj Rat; Plant -
sulfoxide of 2-[N-(2,4-dimethyl-3-thienyl)-N-(2-methoxy-1-methylethyl)amino]-2-oxoethyl cysteine - Rat -
N-(2,4-dimethyl-3-thienyl)-N-(2-hydroxy-1-methylethyl)-2-(methylsulfinyl)acetamide - Rat -
N-(2,4-dimethyl-3-thienyl)-N-(2-methoxy-1-methylethyl)acetamide dechlorinated dimethanamid Sediment; Water -
2-[N-(2,4-dimethyl-3-thienyl)-N-(2-methoxy-1-methylethyl)amino]-2-oxoethyl thioglycolic acid - Rat -
sulfoxide of 2-[N-(2,4-dimethyl-3-thienyl)-N-(2-methoxy-1-methylethyl)amino]-2-oxoethyl thiolactic acid - Rat -
N-(2-hydroxymethyl-4-methyl-3-thienyl)-N-(2-methoxy-1-methylethyl)-2-(methylsulfinyl)acetamide - Rat -
N-acetyl-S-(2-(N'-(2,4-dimethyl-3-thienyl)-N'-(2-methoxy-1-methylethyl)amino)-2-oxoethyl)cysteine mercapturate conj Rat -
methylated N-(2,4-dimethyl-3-thienyl-N-(2-methoxy-2-methylthio-acetyl)alanine - Rat -
2-chloro-N-(2,4-dimethyl-3-thienyl)- N-(2-hydroxy-1-methylethyl)acetamide - - -
N-(2,4-dimethyl-3-thienyl)-N-(2-hydroxy-1-methylethyl)-2-(methylsulfonyl)acetamide - Rat -
4-(2,4-dimethyl-3-thienyl)-6-hydroxy-5-methyl-3-morpholinone - Rat -
sulfoxide of 2-[N-(2,4-dimethyl-3-thienyl)-N-(2-methoxy-1-methylethyl)amino]-2-oxoethyl-N-malonyl cysteine - Rat -
ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
429
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
Moderate
Mammals - Short term dietary NOEL
(mg kg⁻¹)
- - -
(ppm diet)
- -
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
150
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat Reproductive NOAEL
Moderate
Birds - Acute LD₅₀ (mg kg⁻¹)
1068
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Colinus virginianus
Moderate
Birds - Short term dietary (LC₅₀/LD₅₀)
> 5620 ppm
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Colinus virginianus
-
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
114
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Colinus virginianus NOAEL
Moderate
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
294.4
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Eisenia foetida
Moderate
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
25.4
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Eisenia foetida
Moderate
Soil micro-organisms
Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes

Dose: 4.93 kg ha⁻¹
-
Collembola
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
12.5
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Folsomia candida
-
Non-target plants
- - -
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 200
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Apis mellifera
Low
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
118.4
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Apis mellifera
Low
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Chronic
- - -
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
200
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Bombus terrestris 48 hr
Low
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 158
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Bombus terrestris 48 hr
Low
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other bee species (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other bee species (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Beneficial insects (Ladybirds)
- - -
Beneficial insects (Lacewings) as Mortality LR₅₀ g ha⁻¹
> 1050
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Chrysoperla carnea
-
Beneficial insects (Parasitic wasps) as Mortality LR₅₀ g ha⁻¹
47.25
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Aphidius rhopalosiphi
-
Beneficial insects (Predatory mites) as Mortality LR₅₀ g ha⁻¹
> 1050
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Typhlodromus pyri
-
Beneficial insects (Ground beetles)
- - -
Aquatic ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
2.6
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Oncorhynchus mykiss
Moderate
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)
2.5
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Oncorhynchus mykiss
Moderate
Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
3.2
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Daphnia magna
Moderate
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
1.25
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Daphnia magna
Moderate
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
2.7
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment )
3 = Unverified data of known source
Americamysis bahia
Moderate
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
0.0060
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Lemna gibba
High
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
0.019
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Pseudokirchneriella subcapitata
Moderate
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
Marine bivalves
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
429
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
Moderate
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
2000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
-
Mammals - Inhalation LC₅₀ (mg l⁻¹)
> 5.16
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat 4 hr (head & nose only)
-
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.04
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
0.08
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
0.04
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Dermal penetration studies (%)
10
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Dangerous Substances Directive 76/464
- - -
Exposure Routes
Public
No unacceptable risks to bystanders identified
Occupational
Acceptable for intended uses
MRLs
European
EU MRL pesticide database 
Great Britain
GB MRL Register 
Notes
-
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Mammalian dose elimination route and rate
- - -
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database)
0 = No data
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source)
3 = Negative
No data found
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
?Possibly, status not identified
Yes, known to cause a problem
Yes, known to cause a problem
Eye irritant Phototoxicant  
Yes, known to cause a problem
XNo, known not to cause a problem
 
General human health issues
Possible liver toxicant
Handling issues
Property
Value and interpretation
General
Prevent generation of mists
Not explosive or oxidising
Not expected to auto-ignite; Not highly flammable
CLP classification 2013
Health: H302, H317
Environment: H400
WHO Classification
Not listed (Not listed)
UN Number
-
Waste disposal & packaging
-
Shelf-life, storage, stability and reactivity
-
TRANSLATIONS
Language
Name
English
dimethenamid-P
French
dimethenamid-P
German
Dimethenamid-P
Danish
dimethenamid-P
Italian
dimetenamid-P
Spanish
dimetenamida-P
Greek
-
Polish
dimetenamid-P
Swedish
-
Hungarian
dimethenamid-P
Dutch
dimethenamide-P
Norwegian
-

Record last updated: 22/08/2024
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242