Fluazaindolizine (Ref: DPX-Q8U80)	Last updated: 15/03/2024
(Also known as: Q8U80)

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SUMMARY

Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate	Ecotoxicity	Human health
Environmental fate High alert: GUS: High leachability	Ecotoxicity Moderate alert: Birds chronic ecotoxicity: Moderate; Fish acute ecotoxicity: Moderate; Fish chronic ecotoxicity: Moderate; Bees acute oral ecotoxicity: Moderate; Earthworms chronic ecotoxicity: Moderate	Human health Moderate alert: Mammals acute toxicity: Moderate; Reproduction/development effects

GENERAL INFORMATION

Description	A selective nematicide for the control of plant parasitic nematodes in both the field and in protected cropping
Example pests controlled	Root-knot nematode (Meloidogyne incognita)
Example applications	Tomato; Cucubits: cucumber, courgette; Aubergine; Pepper; Strawberry; Oranges; Peaches; Kiwi; Potato; Root & tuber vegetables including carrots
Efficacy & activity	Efficacy demonstrated in extensive field trials
Availability status	Novel
Introduction & key dates	-

UK regulatory status

UK COPR regulatory status	Not applicable
Date COPR inclusion expires	Not applicable
UK LERAP status	No UK approval for use

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status	Pending
Dossier rapporteur/co-rapporteur	Malta
Date EC 1107/2009 inclusion expires	Not applicable
EU Candidate for substitution (CfS)	Not applicable
Listed in EU database	No
Approved for use (✓) under EC 1107/2009 in the following EU Member States	ATAustria BEBelgium BGBulgaria CYCyprus CZCzech Republic DEGermany DKDenmark EEEstonia ELGreece                   ESSpain FIFinland FRFrance HRCroatia HUHungary IEIreland ITItaly LTLithuania LULuxembourg                   LVLatvia MTMalta NLNetherlands PLPoland PTPortugal RORomania SESweden SISlovenia SKSlovakia
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries	ISIceland NONorway

Additional information

Also used in	USA

Chemical structure

Isomerism	None. Fluazaindolizine is not a chiral molecule
Chemical formula	C₁₆H₁₀Cl₂F₃N₃O₄S
Canonical SMILES	COC1=CC(=C(C=C1)Cl)S(=O)(=O)NC(=O)C2=CN3C=C(C=C(C3=N2)Cl)C(F)(F)F
Isomeric SMILES	-
International Chemical Identifier key (InChIKey)	PHCCDUCBMCYSNQ-UHFFFAOYSA-N
International Chemical Identifier (InChI)	InChI=1S/C16H10Cl2F3N3O4S/c1-28-9-2-3-10(17)13(5-9)29(26,27)23-15(25)12-7-24-6-8(16(19,20)21)4-11(18)14(24)22-12/h2-7H,1H3,(H,23,25)
2D structure diagram/image available?	Yes

General status

Pesticide type	Nematicide, Insecticide
Substance groups	Imidazopyridine nematicide; Pyridine nematicide; Sulfonamide nematicide
Minimum active substance purity	961 g kg⁻¹
Known relevant impurities	-
Substance origin	Synthetic
Mode of action	Selective
CAS RN	1254304-22-7
EC number	832-861-0
CIPAC number	986
US EPA chemical code	-
PubChem CID	-
CLP index number	No data found
Molecular mass	468.24
PIN (Preferred Identification Name)	8-chloro-N-(2-chloro-5-methoxybenzene-1-sulfonyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide
IUPAC name	8-chloro-N-((2-chloro-5-methoxyphenyl)sulfonyl)-6-(trifluoromethyl)imidazo(1,2-a)pyridine-2-carboxamide
CAS name	8-chloro-N-((2-chloro-5-methoxyphenyl)sulfonyl)-6-(trifluoromethyl)imidazo(1,2-a)pyridine-2-carboxamide
Other status information	-
Relevant Environmental Water Quality Standards	-
Herbicide Resistance Class (HRAC MoA class)	Not applicable
Herbicide Resistance Class (WSSA MoA class)	Not applicable
Insecticide Resistance Class (IRAC MoA class)	Not known
Fungicide Resistance Class (FRAC MOA class)	Not applicable
Examples of recorded resistance	-
Physical state	Off-white coloured solid

Formulations

Property	Value
Example manufacturers & suppliers of products using this active now or historically	Corteva AgriScience
Example products using this active	Salibro Reklemel Active
Formulation and application details	-

ENVIRONMENTAL FATE

Property		Value	Source; quality score; and other information	Interpretation
Solubility - In water at 20 °C (mg l⁻¹)		2148	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	High
Solubility - In organic solvents at 20 °C (mg l⁻¹)		35050	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Acetonitrile	-
		3470	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Methanol	-
		99760	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Acetone	-
		27620	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Ethyl acetate	-
Melting point (°C)		218.5	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Boiling point (°C)		Decomposes before boiling	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Degradation point (°C)		260	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Flashpoint (°C)		-	-	-
Octanol-water partition coefficient at pH 7, 20 °C	P	6.92 X 10-01	Calculated	-
	Log P	-0.16	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Low
Fat solubility of residues	Solubility	-	-	-
	Data type	-	-	-
Density (g ml⁻¹)		0.619	P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes	-
Dissociation constant pKa) at 25 °C		5.60	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
		-
Vapour pressure at 20 °C (mPa)		-	-	-
Henry's law constant at 25 °C (Pa m³ mol⁻¹)		-	-	-
Volatilisation as max % of applied dose lost	From plant surface	-	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes 24 hr	-
	From soil surface	Negligible	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes 24 hr	-
Maximum UV-vis absorption L mol⁻¹ cm⁻¹		202nm=48000; 235nm=50000, 298nm=6500 at pH 1.8, 7.0 & 10.5	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data	-
Surface tension (mN m⁻¹)		-	-	-

Degradation

Property		Value	Source; quality score; and other information	Interpretation
General biodegradability		Not readily biodegradable
Soil degradation (days) (aerobic)	DT₅₀ (typical)	31.8	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Moderately persistent
	DT₅₀ (lab at 20 °C)	31.8	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Moderately persistent
	DT₅₀ (field)	31.95	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Moderately persistent
	DT₉₀ (lab at 20 °C)	330.0	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Persistent
	DT₉₀ (field)	217.0	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
	DT₅₀ modelling endpoint	46.8	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes (normalised geometric mean)	-
	Note	EU 2023 dossier Lab studies DT₅₀ (normalised) range 3.9-241.3 days; DT₉₀ (measured) 19.0-1000 days; Soils=13; Field data DT₅₀ (measured) range 3.8-79.8 days; DT₉₀ (measured) range 24.2-498.0 days, Soils=12
Dissipation rate RL₅₀ (days) on plant matrix	Value	-	-	-
	Note	-
Dissipation rate RL₅₀ (days) on and in plant matrix	Value	-	-	-
	Note	-
Aqueous photolysis DT₅₀ (days) at pH 7	Value	-	-	-
	Note	-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7	Value	Stable	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Stable
	Note	Stable at all environmentally relevant pH values
Water-sediment DT₅₀ (days)		32.5	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Moderately fast
Water phase only DT₅₀ (days)		30.3	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Stable
Air degradation		As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀		-

Soil adsorption and mobility

Property		Value	Source; quality score; and other information	Interpretation
Linear	Kd (mL g⁻¹)	3.1	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data	Moderately mobile
	Koc (mL g⁻¹)	198.4
	Notes and range	EU 2023 dossier kd range 1.42-4.61 mL g⁻¹; Koc range 148-254 mL g⁻¹, Soils=5
Freundlich	Kf (mL g⁻¹)	1.81	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	Moderately mobile
	Kfoc (mL g⁻¹)	124.8
	1/n	0.855
	Notes and range	EU 2023 dossier kf range 0.94-2.84 mL g⁻¹; Kfoc range 91.5-168 mL g⁻¹, 1/n range 0.833-0.884, Soils=5
pH sensitivity		None

Fate indices

Property		Value	Source; quality score; and other information	Interpretation
GUS leaching potential index		2.86	Calculated	High leachability
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate	Value	2.27 X 10-01	Calculated	-
	Note	-
Potential for particle bound transport index		Low	Calculated	-
Potential for loss via drain flow		Moderately mobile	Calculated	-
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk		32.6	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Calculated using the Atkinson method. Assumed 1.5E+06 OH/cm³, 12 hr	Below the level of concern for long-range air transport
Bio-concentration factor	BCF (l kg⁻¹)	-	-	-
	CT₅₀ (days)	-		-

Known soil metabolites

Metabolite	Major/Minor fraction	Estimated maximum occurrence fraction	Notes
8-chloro-N-[(2-chloro-5-hydroxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-REG72)	Minor fraction	0.038	-
3-chloro-5-(trifluoromethyl)pyridin-2-amine (Ref: IN-VM862)	Major fraction	0.199	-
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-RYC33)	Minor fraction	-	-
2-chloro-5-hydroxybenzenesulfonamide (Ref: IN-A5760)	Major fraction	0.055	-
2-chloro-5-methoxybenzenesulfonamide (Ref: IN-F4106)	Major fraction	0.860	-
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid (Ref: IN-QEK31)	Major fraction	0.790	-

Known groundwater metabolites

Metabolite	EC SANCO/221/2000 relevancy	ADI (mg kg⁻¹ bodyweight day⁻¹)	WHO drinking water guidance value (μg L⁻¹ day⁻¹)
2-chloro-5-hydroxybenzenesulfonamide (Ref: IN-A5760)	Not relevant	0.3	1800
2-chloro-5-methoxybenzenesulfonamide (Ref: IN-F4106)	Not relevant	0.3	1800
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid (Ref: INQEK31)	Not relevant	0.3	1800
3-chloro-5-(trifluoromethyl)pyridin-2-amine (Ref: IN-VM862)	Not relevant	0.02	1200

Other known metabolites

Metabolite name and reference	Aliases	Formation medium / Rate	Estimated maximum occurrence fraction
2-chloro-5-hydroxybenzenesulfonamide (Ref: IN-A5760)	-	Plant; Animal; Rat	-
2-chloro-5-methoxybenzenesulfonamide (Ref: IN-F4106)	-	Water/sediment systems; Plant; Animal; Rat/Mouse	-
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid (Ref: IN-QEK31)	-	Water/sediment systems; Plant; Animal; Rat/Mouse	-
3-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]-L-alanine hydrochloride (Ref: IN-QZY47)	-	Plant	-
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid methyl ester (Ref: IN-R2W56)	-	Plant; Animal	-
2-chloro-5-(beta-D-glucopyranosyloxy) (Ref: IN-R3Z85)	-	Plant	-
5-(trifluoromethyl)pyridin-2-amine (Ref: IN-R6P21)	-	Surface water (aqueous hydrolysis)	-
8-chloro-N-[(2-chloro-5-hydroxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-REG72)	-	Water/sediment systems; Plant; Animal; Rat/Mouse	-
8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-RYC33)	-	Plant; Animal; Rat	-
3-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]-(2R)-hydroxypropanoic acid, potassium salt (Ref: IN-TMQ01) Note: R-enantiomer of IN-RSU03	-	Plant	-
3-[[(2-chloro-5-hydroxyphenyl)sulfonyl]amino]-(2R)-hydroxypropanoic acid potassium salt (Ref: IN-TQD54) Note: R-enantiomer of IN-UNS90	-	Plant	-
N-(carboxyacetyl)-3-[[(2-chloro-5methoxyphenyl)sulfonyl]-amino]-L-alanine (Ref: IN-TUT81)	-	Plant	-
beta-D-glucopyranose 1-[8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate] (Ref: IN-UGA20)	-	Plant	-
8-chloro-N-[(2-chloro-hydroxy-5-methoxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-UHD20)	-	Rat/Mouse	-
8-chloro-N-[(2-chloro-4,5-dihydroxyphenyl)sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-UHD21)	-	Rat/Mouse	-
3-[[(2-chloro-5-hydroxyphenyl)sulfonyl]amino]-L-alanine hydrochloride (Ref: IN-UJV12) Note: S-enantiomer	-	Plant	-
2-[[[8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl]oxy]butanedioic acid (Ref: IN-UJU44)	-	Plant	-
N-[(2-chloro-5-methoxyphenyl)sulfonyl]-8-hydroxy-6-(trifluoromethyl)- imidazo[1,2-a]pyridine-2-carboxamide (Ref: IN-URA40)	-	Surface water (aqueous photolysis)	-
3-chloro-5-(trifluoromethyl)pyridin-2-amine (Ref: IN-VM862)	-	Sediments; Surface water (aqueous photolysis); Plants	-
N-[[8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl]carbonyl]-L-glutamic acid (Ref: IN-WUK12)	-	Plant	-
2-chloro-5-(beta-L2-glucopyranuronosyloxy)benzenesulfonamide	-	Animal	-
2-chloro-5-(sulfooxy)benzenesulfonamide	-	Animal; Rat/Mouse	-
2-chloro-4-(beta-L-Lglucopyranuronosyloxy)-benzenesulfonamide	-	Rat (bile)	-
8-chloro-N-[(2-chloro-5-(beta-D-glucopyranosyl) phenyl) sulfonyl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxamide	-	Plant	-
8-chloro-N-[[2-chloro-5-(sulfooxy)phenyl]sulfonyl]-6-(trifluoromethyl) imidazo[1,2-a]pyridine-2-carboxamide	-	Rat (bile)	-
3-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]-(2R)-(beta-D-glucopyranosyloxy)propanoic acid	-	Plant	-
mono[1-carboxy-(2R)-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]ethyl]-propanedioic acid ester	-	Plant	-
(2R)-[[6-O-(2-carboxyacetyl)-beta-D-glucopyranosyl]oxy]-3-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]-propanoic acid	-	Plant	-
8-hydroxy-6-(trifluoromethyl)- imidazo[1,2-a]pyridine-2-carboxamide	-	Surface water (aqueous photolysis)	-
3-[[[2-chloro-5-(beta-D-glucopyranosyloxy)phenyl]sulfonyl]-amino]-(2R)-hydroxypropanoic acid	-	Plant	-
imidazo[1,2-a]pyridine-2-carboxylic acid, 8-chloro-6-(trifluoromethyl)-, 3-(hexopyranuronosyloxy)-2-hydroxypropyl ester	-	Plant	-
N-acetyl-3-[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]-L-alanine	-	Plant; Rat	-
N-acetyl-3-[[(2-chloro-5-hydroxyphenyl)sulfonyl]amino]-L-alanine	-	Rat	-
N-acetyl-3-[[[2-chloro-5-(sulfooxy)phenyl]sulfonyl]-amino]-L-alanine	-	Rat	-
2-chloro-4-hydroxy-5-(sulfooxy)-benzenesulfonamide	-	Rat	-
4-[4-[[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]carbonyl]-1H-imidazol-2-yl]-4-oxo-2-(trifluoromethyl)-(2E/Z)-butenoic acid (Ref: IN-UGA22) Note: Unstable in water	-	Surface water (aqueous photolysis)	-
4-[[[(2-chloro-5-methoxyphenyl)sulfonyl]amino]carbonyl]-1H-imidazole-2-carboxylic acid (Ref: IN-UGA26)	-	Surface water (aqueous photolysis)	-
N-[(2-chloro-5-methoxyphenyl)sulfonyl]-1H-imidazole-4-carboxamide (Ref: IN-UHC58)	-	Surface water (aqueous photolysis)	-
[(2S,3R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]1-[8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate] (Ref: IN-UHD13)	-	Plant	-

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property		Value	Source; quality score; and other information	Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)		940	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg⁻¹)	-	-	-
	(ppm diet)	-		-
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)		-	-	-
Birds - Acute LD₅₀ (mg kg⁻¹)		> 2250	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Colinus virginianus	Low
Birds - Short term dietary (LC₅₀/LD₅₀)		-	-	-
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)		51.1	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Colinus virginianus as NOEC	Moderate
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)		> 1000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Eisenia foetida	Low
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)		100	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Eisenia foetida	Moderate
Soil micro-organisms		Nitrogen transformation: No significant adverse effect	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes % effect 28 Day onwards	-
Collembola	Acute LC₅₀ (mg kg⁻¹)	-	-	-
	Chronic NOEC (mg kg⁻¹)	500	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Folsomia candida	-
Non-target plants		-	-	-
		-	-	-
Honeybees (Apis spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	> 200	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Apis mellifera	Low
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	> 19.62	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Apis mellifera	Moderate
	Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
	Chronic	-	-	-
Bumblebees (Bombus spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	> 200	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Bombus terrestris	Low
		-
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	> 176	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Bombus terrestris	Low
		-
Mason bees (Osmia spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
Other bee species (1)	Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)	-	-	-
	Mode of exposure	-
Other bee species (2)	Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)	-	-	-
	Mode of exposure	-
Beneficial insects (Ladybirds)		-	-	-
Beneficial insects (Lacewings)		-	-	-
Beneficial insects (Parasitic wasps) as mL product (500g l⁻¹)/ha		> 2000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Aphidius rhopalosiphi	-
Beneficial insects (Predatory mites) as mL product (500 g l⁻¹)/ha		> 2000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Typhlodromus pyri	-
Beneficial insects (Ground beetles)		-	-	-

Aquatic ecotoxicology

Property		Value	Source; quality score; and other information	Interpretation
Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)		> 30.0	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data Cyprinodon variegatus marine species	Moderate
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)		0.75	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Cyprinodon variegatus	Moderate
Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)		-	-	-
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)		> 120	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Daphnia magna	Low
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)		-	-	-
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)		-	-	-
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)		> 30	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Americamysis bahia	Moderate
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)		> 120	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Chironomus riparius	Low
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)		35.0	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Chironomus riparius	Low
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)		37.0	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Chironomus riparius	Moderate
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)		28.5	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Lemna gibba	Low
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)		46.0	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Pseudokirchneriella subcapitata	Low
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)		-	-	-
Mesocosm study data	NOEAEC mg l⁻¹	-	-	-
	NOEAEC mg l⁻¹	-	-	-

HUMAN HEALTH AND PROTECTION

General

Property		Value	Source; quality score; and other information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		High (class III)	-	-
Mammals - Acute oral LD₅₀ (mg kg⁻¹)		940	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat	Moderate
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)		2000	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat	-
Mammals - Inhalation LC₅₀ (mg l⁻¹)		> 5.3	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat 4 hr (nose only)	-
Other Mammal toxicity endpoints		-	-	-
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)		0.3	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat SF=100	-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)		1.25	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat SF=100	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)		0.64	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat SF=100	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)		0.15	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Rat SF=100	-
Dermal penetration studies (%)		1.7-13.0	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes concentration dependent	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Routes	Public	Negligible exposure expected for bystanders, consumers and the general public
	Occupational	Negligible exposure expected for operators
MRLs	European	EU MRL pesticide database
	Great Britain	GB MRL Register
	Notes	-
Drinking Water Standards		-	-	-
Drinking Water MAC (μg l⁻¹)		-	-	-
Mammalian dose elimination route and rate		Majority (>90%) of administered dose excreted in urine and feces over 48 hours. Metabolised in humans.	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-

Health issues

Specific human health issues		Carcinogen Genotoxic Endocrine disruptor XNo, known not to cause a problem A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative XNo, known not to cause a problem Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant ?Possibly, status not identified No data found XNo, known not to cause a problem Respiratory tract irritant Skin irritant Skin sensitiser No data found XNo, known not to cause a problem XNo, known not to cause a problem Eye irritant Phototoxicant   XNo, known not to cause a problem ✓Yes, known to cause a problem
General human health issues		Possible kidney, gall bladder, liver toxicant

Handling issues

Property	Value and interpretation
General	Not expected to auto-ignite; Not highly flammable; Melts rather than combusts Not explosive or oxidising
CLP classification 2013	Health: H373, H302 Environment: H411
WHO Classification	Not listed (Not listed)
UN Number	-
Waste disposal & packaging	-
Shelf-life, storage, stability and reactivity	Technical fluazaindolizine is expected to be stable during storage under normal conditions for at least 2 years.

TRANSLATIONS

Language	Name
English	fluazaindolizine
French	fluazaindolizine
German	-
Danish	-
Italian	-
Spanish	-
Greek	-
Polish	-
Swedish	-
Hungarian	-
Dutch	-
Norwegian	-

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Record last updated:	15/03/2024
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242