Cyclobutrifluram |

Last updated: 23/01/2025
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(Not known by any other names) |
Cyclobutrifluram is a multi-use pesticide which is mostly used as a nematicide. It is moderately soluble in water, very soluble in most organic solvents and is non-volatile. It can be persistent in soil systems under certain conditions - it degrades quicker in moist soils than in dry ones. It tends to demonstrate a low toxicity to humans or biodiversity. |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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A multi-use pesticide that offers control of a broad spectrum of nematode pests and diseases across all major crops |
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Nematodes including Ring, Southern Sting, Root-knot, Stuby, Dagger, Sheath, Spiral and Beet cyst nematodes; Soil-borne diseases, especially Fusarium |
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Soybean; Cotton; Romaine lettuce; Ornamentals; Turf; Cucumber; Tomato; Corn; Sugarbeet; Banana; Pepper; Coffee; Melon; Tobacco; Wheat; Barley |
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Efficacy as a nematicide established from extensive field trials |
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Current |
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2103, first patent; 2020, introduction |
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Not approved |
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Not applicable |
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No UK approval for use as a pesticide |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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Australia; Argentina; Chile; China; Belize; Columbia; El Salvador; Paraguay; South Korea; Vietnam; Zimbabwe; Guatemala |
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Isomeric - containing 80–100% of the (1S,2S)-enantiomer and 20–0% of the (1R,2R)-enantiomer |
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C₁₇H₁₃Cl₂F₃N₂O |
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- |
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- |
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GBFKIHJZPMECCF-FZMZJTMJSA-N |
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InChI=1S/C17H13Cl2F3N2O/c18-9-3-4-10(13(19)8-9)11-5-6-14(11)24-16(25)12-2-1-7-23-15(12)17(20,21)22/h1-4,7-8,11,14H,5-6H2,(H,24,25)/t11-,14-/m0/s1 |
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Yes |
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Fungicide, Nematicide |
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Pyridine fungicide; Amide fungicide; Pyridine nematricide; Amide nematicide |
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- |
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- |
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Synthetic |
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An SDHI fungicide. Inhibitor of the mitochondrial electron transport chain complex II |
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1460292-16-3 |
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856-353-3 |
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None allocated |
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126002 |
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- |
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389.2 |
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N-[2-(2,4-dichlorophenyl)cyclobutyl]-2-(trifluoromethyl)pyridine-3-carboxamide |
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N-[2-(2,4-dichlorophenyl)cyclobutyl]-2-(trifluoromethyl)pyridine-3-carboxamide |
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rel-N-[(1R,2R)-2-(2,4-dichlorophenyl)cyclobutyl]-2-(trifluoromethyl)-3-pyridinecarboxamide |
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- |
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- |
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Not applicable |
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Not applicable |
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N-3 |
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C2 |
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None identified |
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Solid, off-white coloured, odourless crystalline powder |
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- Tymirium
- Victrato
- Trefinti Turf nematicide
- Vaniva
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Formulated for application as a suspension concentrate via soil treatment or as a seed treatment. |
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19 |
P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data |
Moderate |
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500000 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Acetone |
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420000 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Methanol |
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390000 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Ethyl acetate |
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69000 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Octanol |
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124.6 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
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- |
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1.58 X 1003 |
Calculated |
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3.2 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
High |
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- |
- |
- |
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- |
- |
- |
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1.4 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
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- |
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- |
- |
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6.2 X 10-03 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
Low volatility |
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7.3 X 10-05 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
Non-volatile |
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Acidic soln: 225nm=12817 Basic soln: 225nm=12970 Neutral soln: 225nm=11792 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
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23 |
P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data |
Non-persistent |
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23 |
P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data |
Non-persistent |
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138 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
Persistent |
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Australian dossier 2024: Lab study: DT₅₀ in moist soil = 14.7 days, in dry soil DT₅₀ 52.8 days. Field studies: DT₅₀ slow under dark aerobic conditions DT₅₀ range 27.1-248 days |
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- |
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18 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
Slow |
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DT₅₀ of 11 to 24 days under summer sunlight |
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Stable |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
Stable |
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Stable at pH4,7 & 9 at temps up to 70 °C |
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697 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
Stable |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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6.46 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
Moderately mobile |
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333 |
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0.87 |
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Australian dossier: Kf range 3.39-9.53 L/kg, Koc range 210-585 L/kg |
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Weak correlation with OC |
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3.16 |
Calculated |
High leachability |
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4.12 X 10-01 |
Calculated |
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Medium |
Calculated |
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Moderately mobile |
Calculated |
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1.73 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Calculated using the Atkinson method, 12 hr |
Below the level of concern for long-range air transport |
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Major fraction |
0.140 |
P5 |
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Major fraction |
0.115 |
P5 |
Known groundwater metabolites |
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None
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Ref: SYN510275 |
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Rat; Animal; Plant |
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Ref: SYN549104 |
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Plant; Animal |
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Ref: SYN552301 |
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Plant |
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Ref: SYN552202 |
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Plant |
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Ref: SYN510275 |
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Plant |
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Ref: SYN510260 |
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Plant |
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trifluoroacetic acid |
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Plant |
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Terrestrial ecotoxicology |
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> 5000 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Rat |
Low |
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> 1264 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Colinus virginianus |
Moderate |
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> 500 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Eisenia andrei |
Moderate |
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212 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Eisenia andrei |
Low |
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> 900 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Various plants n=10 Seedling emergence, ER₅₀ as g ha⁻¹ |
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> 900 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Various plants n=10 Vegetative vigour, ER₅₀ as g ha⁻¹ |
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> 200 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Apis mellifera |
Low |
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> 72 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Apis mellifera |
Moderate |
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> 30 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Apis mellifera Larvae |
Moderate |
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11.0 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Pimephales promelas |
Moderate |
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0.33 |
P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data Cassostrea virginica |
Moderate |
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9.5 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Raphidocelis subcapitata |
Moderate |
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HUMAN HEALTH AND PROTECTION |
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High (Class III) |
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> 5000 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Rat |
Low |
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0.08 |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes Australia |
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EU MRL pesticide database |
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Excretion usually in 72-168 hrs after dosing, Major route is via bile and urine |
P5 P = Other non-EU, UK or US Governments and Regulators 5 = Verified data used for regulatory purposes |
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Carcinogen |
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Endocrine disruptor |
XNo, known not to cause a problem |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
XNo, known not to cause a problem |
No data found |
XNo, known not to cause a problem |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
XNo, known not to cause a problem |
XNo, known not to cause a problem |
Eye irritant |
Phototoxicant |
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?Possibly, status not identified |
No data found |
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No information available |
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Not flammable Not explosive Slightly corrosive to some metals |
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Not listed (Not listed) |
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Stable at room temperature >1 yr. |
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cyclobutrifluram |
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cyclobutrifluram |
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Record last updated: |
23/01/2025 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |