Foramsulfuron (Ref: AE F130360)

Foramsulfuron (Ref: AE F130360)	Last updated: 22/08/2024
(Not known by any other names)

SUMMARY

Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate	Ecotoxicity	Human health
Environmental fate High alert: GUS: High leachability	Ecotoxicity Moderate alert: Birds chronic ecotoxicity: Moderate; Daphnia acute ecotoxicity: Moderate; Earthworms acute ecotoxicity: Moderate; Earthworms chronic ecotoxicity: Moderate	Human health Low alert

GENERAL INFORMATION

Description

A selective post-emergence herbicide for grass and broad-leaved weed control mainly in corn and turf

Example pests controlled

Broad-leaved weeds, Perennial rye grass (Lolium perenne), Winter grass (Poa annua), Crowsfoot grass (Eleusine indica)

Example applications

Corn; Golf courses; Lawns; Athletic fields; Recreational areas

Efficacy & activity

Availability status

Current

Introduction & key dates

1995, first synthesised; 2001, first reported

GB regulatory status

GB COPR regulatory status

Approved

Date COPR inclusion expires

31/05/2035

GB LERAP status

No data

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Approved

Dossier rapporteur/co-rapporteur

Finland/Slovakia

Date EC 1107/2009 inclusion expires

31/05/2035

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece
✓	✓	✓	✓	✓	✓	✓	✓	✓
ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg
✓	✓	✓	✓	✓	✓	✓	✓	✓
LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia
✓		✓	✓	✓	✓	✓	✓	✓

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway
	✓

Additional information

Also used in

Australia, Canada, Russia, Morocco

Chemical structure

Isomerism

None

Chemical formula

C₁₇H₂₀N₆O₇S

Canonical SMILES

CN(C)C(=O)C1=C(C=C(C=C1)NC=O)S(=O)(=O)NC(=O)NC2=NC(=CC(=N2)OC)OC

Isomeric SMILES

No data

International Chemical Identifier key (InChIKey)

PXDNXJSDGQBLKS-UHFFFAOYSA-N

International Chemical Identifier (InChI)

InChI=1S/C17H20N6O7S/c1-23(2)15(25)11-6-5-10(18-9-24)7-12(11)31(27,28)22-17(26)21-16-19-13(29-3)8-14(20-16)30-4/h5-9H,1-4H3,(H,18,24)(H2,19,20,21,22,26)/f/h18,21-22H

2D structure diagram/image available?

Yes

General status

Pesticide type

Herbicide

Substance groups

Pyrimidinylsulfonylurea herbicide; Sulfonylurea herbicide

Minimum active substance purity

973 g kg⁻¹

Known relevant impurities

EU dossier - None declared

Substance origin

Synthetic

Mode of action

Acetolactate synthase (ALS) inhibitor stunting growth and causing death.

CAS RN

173159-57-4

EC number

605-666-1

CIPAC number

659

US EPA chemical code

122020

PubChem CID

11419598

CLP index number

No data found

Molecular mass

452.44

PIN (Preferred Identification Name)

IUPAC name

1-(4,6-dimethoxypyrimidin-2-yl)-3-[2-(dimethylcarbamoyl)-5-formamidophenylsulfonyl]urea

CAS name

2-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-4-(formylamino)-N,N-dimethylbenzamide

Other status information

Marine pollutant

Relevant Environmental Water Quality Standards

Herbicide Resistance Class (HRAC MoA class)

Herbicide Resistance Class (WSSA MoA class)

Insecticide Resistance Class (IRAC MoA class)

Not applicable

Fungicide Resistance Class (FRAC MOA class)

Not applicable

Examples of recorded resistance

Setaria faberi

Physical state

White powder

Formulations

Property

Value

Example manufacturers & suppliers of products using this active now or historically

Aventis
Bayer CropScience

Example products using this active

Option
Revolver
Tribute
Equip OD
MaisTer

Formulation and application details

Usually supplied as water dispersible granules

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C (mg l⁻¹)

3293

High

Solubility - In organic solvents at 20 °C (mg l⁻¹)

1925

Acetone

362

Ethyl acetate

Heptane

1660

Methanol

Melting point (°C)

194.5

Boiling point (°C)

Decomposes before boiling

Degradation point (°C)

190

Flashpoint (°C)

Octanol-water partition coefficient at pH 7, 20 °C

1.66 X 10^-01

Calculated

Log P

-0.78

Low

Fat solubility of residues

Solubility

Insoluble

Data type

Regulatory data

Density (g ml⁻¹)

1.44

Dissociation constant pKa) at 25 °C

4.6

Weak acid

Vapour pressure at 20 °C (mPa)

4.20 X 10^-08

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

5.80 X 10^-12

Non-volatile

Volatilisation as max % of applied dose lost

From plant surface

Negligible

From soil surface

Negligible

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

291nm = 3300, 252nm = 33300, 219nm = 31900

Surface tension (mN m⁻¹)

65.1

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

25.4

Non-persistent

DT₅₀ (lab at 20 °C)

25.3

Non-persistent

DT₅₀ (field)

DT₉₀ (lab at 20 °C)

77.1

Moderately persistent

DT₉₀ (field)

DT₅₀ modelling endpoint

Note

EU dossier (2016) lab studies DT₅₀ range 1.8-82.0 days, DT₉₀ range 10.3-222.4 days, Soils=12; Other sources: DT₅₀ 15 days (DW4)

Dissipation rate RL₅₀ (days) on plant matrix

Value

Note

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Stable

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

128

Persistent

Note

pH sensitive: DT₅₀ 3.7 days at pH 4, 10 days at pH 5, 132 days at pH 9, all at 25 °C

Water-sediment DT₅₀ (days)

32.9

Moderately fast

Water phase only DT₅₀ (days)

25.2

Slow

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

K_oc (mL g⁻¹)

Notes and range

Freundlich

K_f (mL g⁻¹)

1.08

Moderately mobile

K_foc (mL g⁻¹)

78.4

¹/_n

0.87

Notes and range

EU dossier (2002 & 2016) K_f range 0.31-2.61 mL g⁻¹, K_foc range 38-151 mL g⁻¹, ¹/_n range 0.82-0.96, Soils=5

pH sensitivity

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

2.95

Calculated

High leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

2.33 X 10^-01

Calculated

Note

Potential for particle bound transport index

Low

Calculated

Potential for loss via drain flow

Moderately mobile

Calculated

Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk

1.68

Calculated using the Atkinson method. Assumed 1.5E+06 OH/cm³, 12 hr

Below the level of concern for long-range air transport

Bio-concentration factor

BCF (l kg⁻¹)

Low risk

Based on LogP < 3

Low risk

CT₅₀ (days)

No data

Known soil metabolites

Metabolite

Major/Minor fraction

$Click here for further information on Major/Minor fraction$

Estimated maximum occurrence fraction

Notes

4-amino-2-(3-(4,6-dimethoxypyrimidin-2-yl)ureidosulfonyl)-N, N-dimethylbenzamide (Ref: AE-F130619)

Major fraction

0.291

2-amino-4,6-dimethoxypyrimidine (Ref: AE-F092944)

Major fraction

0.178

4-formylamino-N,N-dimethyl-2-sulfamoylbenzamide (Ref: AE-F153745)

Minor fraction

0.078

Known groundwater metabolites

None

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

6-formamido-1,2-benzisothiazol-3(2H)-one 1,1 dioxide (Ref: AE-0014940)

Water (Hydrolysis, Aerobic)

4-formamido-2-{[(4-methoxy-6-oxo-1,6-dihydropyrimidin-2-yl)carbamoyl]sulfamoyl}-N,N-dimethylbenzamide (Ref: AE-0338795)

Water; Sediment

6-amino-1,2-benzisothiazol-3(2H)-one 1,1 dioxide (Ref: AE-0001082)

Water (Hydrolysis)

N-dimethyl-2-sulfamoylbenzamide-4-formylamino-N (Ref: AE-F153745)

foramsulfuron sulfonamide

Water (Hydrolysis); Water; Sediment; Plant

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 5000

Rat

Low

Mammals - Short term dietary NOEL

(mg kg⁻¹)

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

1038

Rat Reproductive NOAEL

Low

Birds - Acute LD₅₀ (mg kg⁻¹)

> 2000

Colinus virginianus

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

> 5000 mg kg feed⁻¹

Colinus virginianus

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

104

Colinus virginianus NOEL

Moderate

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)

453

Eisenia foetida as product

Moderate

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)

>= 2.75

Eisenia foetida

Moderate

Soil micro-organisms

Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect

Dose: 0.45 kg ha⁻¹

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

178

Folsomia candida

Non-target plants

38.8

Lactuca sativa
Seedling emergence, ER₅₀
as g ha⁻¹

1.88

Raphanus sativus
Vegetative vigour, ER₅₀
as g ha⁻¹

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 100

Apis mellifera

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 110.1

Apis mellifera

Low

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds)

Beneficial insects (Lacewings)

Beneficial insects (Parasitic wasps) as Mortality LR₅₀ g ha⁻¹

5.6

Aphidius rhopalosiphi

Beneficial insects (Predatory mites) as Mortality LR₅₀ g ha⁻¹

> 62.2

Typhlodromus pyri

Beneficial insects (Ground beetles)

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

> 100

Oncorhynchus mykiss

Low

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

10.5

Pimephales promelas

Low

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

100

Daphnia magna

Moderate

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

> 100

Daphnia magna

Low

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)

0.001

Lemna gibba

High

Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)

8.1

Anabaena flos-aquae

Moderate

Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 5000

Rat

Low

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 5.04

Rat 4 hr (nose only)

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.25

Rat SF=100

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

None allocated

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.1

Rabbit SF=500

Dermal penetration studies (%)

Dangerous Substances Directive 76/464

Exposure Routes

Public

No unacceptable risks to bystanders identified

Occupational

No unacceptable risks to operators or other workers identified

MRLs

European

EU MRL pesticide database

Great Britain

GB MRL Register

Notes

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Mammalian dose elimination route and rate

Rapid and extensive excretion, mainly via the faeces

Health issues

Specific human health issues

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

No data found

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

Respiratory tract irritant

Skin irritant

Skin sensitiser

Eye irritant

Phototoxicant

General human health issues

Some data sources suggest substance causes serious eye irritation

Handling issues

Property

Value and interpretation

General

Avoid dust generation - under certain conditions explosion may occur
Not oxidising
Not expected to auto-ignite; Not highly flammable

CLP classification 2013

Environment: H412

WHO Classification

Not listed (Not listed)

UN Number

UN3082

Waste disposal & packaging

Packaging Group III (minor danger)

Shelf-life, storage, stability and reactivity

TRANSLATIONS

Language

Name

English

foramsulfuron

French

foramsulfuron

German

Foramsulfuron

Danish

foramsulfuron

Italian

foramsulfuron

Spanish

foramsulfuron

Greek

Polish

foramsulfuron

Swedish

foramsulfuron

Hungarian

foramsulphuron

Dutch

Norwegian

foramsulfuron

Record last updated:	22/08/2024
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242