The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate
Ecotoxicity
Human health
Environmental fate Moderate alert: Drainflow: Moderately mobile
There are three mainmechanisms (i) disruption of mitochondrial function, (ii) ATP depletion, and (iii) Proton-Motive Force Disruption
CAS RN
88-30-2
EC number
201-818-2
CIPAC number
-
US EPA chemical code
-
PubChem CID
6931
Molecular mass
207.11
PIN (Preferred Identification Name)
-
IUPAC name
4-nitro-3-(trifluoromethyl)phenol
CAS name
3-trifluoromethyl-4-nitrophenol
Forever chemical
PFAS
Other status information
-
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Class (HRAC MoA class)
Not applicable
Herbicide Resistance Class (WSSA MoA class)
Not applicable
Insecticide Resistance Class (IRAC MoA class)
Not applicable
Fungicide Resistance Class (FRAC MOA class)
Not applicable
Examples of recorded resistance
-
Physical state
Yellow to orange coloured solid
Commercial
Property
Value
Availability status
Current
Introduction & key dates
1958, discovered; 1964, first registered in US
Example manufacturers & suppliers of products using this active now or historically
MilliporeSigma
Cayman Chemical
Example products using this active
Unbranded and usuage managed by the Great Lakes Fishery Commission
Formulation and application details
Supplied as a liquid concentrate and applied by metered pump from the back of a boat or by backpack sprayer
Commercial production
The production of 3-trifluoromethyl-4-nitrophenol involves a multi-step synthetic route starting with the preparation of 3-(trifluoromethyl)-4-nitroacetanilide, which is then hydrolysed using a mixture of concentrated sulphuric acid and water to yield 3-(trifluoromethyl)-4-nitroaniline. This intermediate undergoes diazotization, forming a diazonium salt that is subsequently hydrolysed in a boiling mixture of xylene and aqueous copper sulphate solution, converting the diazonium group into a hydroxyl group and producing the final phenol compound.
Impact on climate of production and use
Data for the amount of life cycle GHGs produced by 3-trifluoromethyl-4-nitrophenol are not available in the public domain. However, whilst estimates vary, more general data suggests that between 14 and 30 kilograms of CO₂e is emitted per kilogram of pesticide produced.
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
Non-persistent
DT₅₀ (lab at 20 °C)
-
-
-
DT₅₀ (field)
-
-
-
DT₉₀ (lab at 20 °C)
-
-
-
DT₉₀ (field)
-
-
-
DT₅₀ modelling endpoint
-
-
-
Note
-
Dissipation rate RL₅₀ (days) on plant matrix
Value
-
-
-
Note
-
Dissipation rate RL₅₀ (days) on and in plant matrix
Value
-
-
-
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
-
-
-
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
-
-
-
Note
-
Water-sediment DT₅₀ (days)
-
-
-
Water phase only DT₅₀ (days)
-
-
-
Sediment phase only DT₅₀ (days)
-
-
-
Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
3.88 X 10-03
Calculated
-
Note
-
Potential for particle bound transport index
Low
Calculated
-
Potential for loss via drain flow
Moderately mobile
Calculated
-
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
500
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
A0 A = Chromosome aberration (EFSA database) 0 = No data
;
B0 B = DNA damage/repair (EFSA database) 0 = No data
;
C0 C = Gene mutation (EFSA database) 0 = No data
;
D0 D = Genome mutation (EFSA database) 0 = No data
;
E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
✓Yes, known to cause a problem
No data found
General human health issues
May cause irreversible eye damage and skin burns May be fatal if swallowed
Handling issues
Property
Value and interpretation
General
Incompatible with strong bases and oxidizers, {Corrosive Combustible When heated to decomposition it emits toxic vapors of nitrogen oxides and hydrogen fluoride
CLP classification 2013
Health: H301, H302, H312, H315, H319, H332, H335
WHO Classification
-
UN Number
-
Waste disposal & packaging
-
Shelf-life, storage, stability and reactivity
Stable under normal environmental conditions but rapidly metabolises in water.
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242
Environmental fate
Warning:
