Trichlorfon (Ref: OMS 800) |
Last updated: 23/08/2024 |
(Also known as: chlorophos; metriphonate; trichlorphon; dipterex; chloroxyphos) |
SUMMARY |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A insecticide and acaricide used to control a variety of insects on an extensive range of crops | |
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Cockroaches; Silverfish; Fleas; Flies; Ticks; Grapevine moth; Banana spotting bug; Passion vine bug; Fruit flies; Cabbage white butterfly; Army worms; Leaf miners | |
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Fruit including apples, pears, plums, cherries, avodado, grapes, passionfruit, blueberries; Peppers; Chillies; Tomatoes; Brassicas; Tomatoes; Linseed; Lucerne; Cereals; Soybean; Rice | |
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- | |
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Current | |
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1957, introduced |
UK regulatory status |
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Not approved | ||
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Expired | ||
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Spain | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Expired | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information |
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Australia |
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Chemical structure |
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A chiral molecule. The technical material is an isomeric mixture of two isomers. | |
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C₄H₈Cl₃O₄P | |
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COP(=O)(C(C(Cl)(Cl)Cl)O)OC | |
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No data | |
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NFACJZMKEDPNKN-UHFFFAOYSA-N | |
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InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3 | |
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Yes |
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Common Name | Relationship | Link |
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trichlorfon | Unstated isomer |
General status |
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Insecticide, Veterinary substance | |
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Organophosphate insecticide; Organophosphate acaricide; Phosphonate acaricide; Phosphonate insecticide | |
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980 g kg⁻¹ | |
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EU dossier - diclorvos 0.02g kg⁻¹ | |
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Synthetic | |
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Non-systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor. | |
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52-68-6 | |
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200-149-3 | |
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68 | |
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057901 | |
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5853 | |
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015-021-00-0 | |
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257.4 | |
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rac-dimethyl [(1R)-2,2,2-trichloro-1-hydroxyethyl]phosphonate | |
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dimethyl (RS)-2,2,2-trichloro-1-hydroxyethylphosphonate | |
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dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate | |
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Evidence of use in third world countries; Chemical subject to PIC regulations | |
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- | |
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Not applicable | |
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Not applicable | |
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1B | |
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Not applicable | |
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Agrotis ipsilon, Blattella germanica, Boophilus microplus, Culex pipiens pallens, Dendrolimus punctatus, many others | |
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Colourless to yellow or pink waxy solid |
Formulations |
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Available in a range of formulations including soluble powders, soluble concentrates, granules and spot-on sticks. |
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120000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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21500 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Xylene5 = Verified data used for regulatory purposes |
- | ||||||||
363000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Ethyl acetate5 = Verified data used for regulatory purposes |
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1346000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Methanol5 = Verified data used for regulatory purposes |
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707000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Acetone5 = Verified data used for regulatory purposes |
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80 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Decomposes before boiling | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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100 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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2.69 X 1000 | Calculated | - | |||||||
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0.43 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Low | ||||||||
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1.68 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Not applicable | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Not determinable | |||||||||||
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0.21 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility. If applied directly to plants, drift is a concern & mitigation is advisable | ||||||||
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4.50 X 10-07 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-volatile | ||||||||
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71.8 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) at 20°C 99.3% 1g l⁻¹5 = Verified data used for regulatory purposes |
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Degradation |
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18 | K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data |
Non-persistent | |||||||
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18 | K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data |
Non-persistent | ||||||||
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Other sources: DT₅₀ 10 days (DW4); General literature DT₅₀ range 7-30 days (R2) | ||||||||||
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2.45 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Published literature RL₅₀ range 0.34-5.16 days, 3 field grown crops, various matrices, n=3 | ||||||||||
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3.9 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Published literature RL₅₀ range 1.6-6.7 days, 9 field & undercover grown crops, various matrices, n=10 | ||||||||||
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Stable | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Stable | |||||||
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No UV degradation | ||||||||||
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1.6 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-persistent | |||||||
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pH sensitive: DT₅₀ 117 days at pH 5, 31 minutes at pH 9, all at 25 °C | ||||||||||
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1.2 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Moderately fast | ||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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[Apple (waxed): 22.8 days @ ambient conditions; Field data], [Apple (natural): 11.8 days @ ambient conditions; Field data] |
Soil adsorption and mobility |
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- | G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data |
Very mobile | |||||||
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10 | ||||||||||
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Fate indices |
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3.77 | Calculated | High leachability | ||||||||||||||||||||||||||
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4.25 X 10-01 | Calculated | - | |||||||||||||||||||||||||
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Low | Calculated | - | ||||||||||||||||||||||||||
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Very mobile | Calculated | - | ||||||||||||||||||||||||||
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41.52 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Calculated using the Atkinson method4 = Verified data |
Below the level of concern for long-range air transport | ||||||||||||||||||||||||||
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0.41 | R4 R = Peer reviewed scientific publications Piaractus mesopotamicus Other data: Low risk LogP<3 (A5)4 = Verified data |
Low potential | |||||||||||||||||||||||||
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Not available | - |
Known soil metabolites |
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Minor fraction | 0.044 | - | |||||
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Major fraction | 0.245 | - | |||||
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Major fraction | 0.376 | - | |||||
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Major fraction | 0.407 | - |
Known groundwater metabolites |
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Relevant | - | - | ||||||
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Relevancy unknown | - | - | ||||||
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Relevancy unknown | - | - |
Other known metabolites |
None
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Terrestrial ecotoxicology |
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212 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 4.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat 2 yr5 = Verified data used for regulatory purposes |
High | |||||||
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> 500 | - | |||||||||
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> 36.8 | G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) Anas platyrhynchos4 = Verified data |
High | ||||||||
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Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect |
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Dose: 7.2 kg ha⁻¹ 28 Day |
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2.85 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Apis mellifera3 = Unverified data of known source |
Moderate | |||||||
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> 0.4 | K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) Apis mellifera4 = Verified data |
High | ||||||||
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568.3 | R3 R = Peer reviewed scientific publications Bombus terricola3 = Unverified data of known source |
Low | |||||||
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7.5 | R4 R = Peer reviewed scientific publications Megachile rotundata4 = Verified data |
Moderate | |||||||
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Contact | ||||||||||
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4.147 | R4 R = Peer reviewed scientific publications Andrena erythronii4 = Verified data |
Moderate | |||||||
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Contact | ||||||||||
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> 91.1 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Chrysoperla carnea Larva4 = Verified data |
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0.519 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Aphidius rhopalosiphi5 = Verified data used for regulatory purposes |
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90 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Typhlodromus pyri Adult4 = Verified data |
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Aquatic ecotoxicology |
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0.7 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Oncorhynchus mykiss3 = Unverified data of known source |
Moderate | ||||||||
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0.5 | P3 P = Other non-EU, UK or US Governments and Regulators Carassius auratus 30 day3 = Unverified data of known source |
Moderate | ||||||||
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16.99 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio Embryo 6 days3 = Unverified data of known source |
Moderate | ||||||||
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0.00096 | L3 L = Pesticide manuals and hard copy reference books / other sources Daphnia magna3 = Unverified data of known source |
High | ||||||||
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10 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Scenedesmus subspicatus3 = Unverified data of known source |
Moderate | ||||||||
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3.2 | Q2 Q = Miscellaneous data from online sources Unknown species2 = Unverified data of unknown source |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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212 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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5000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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> 0.53 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Intraperitoneal LD₅₀ = 160 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intramuscular LD₅₀ = 395 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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0.045 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
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0.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
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0.09 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=5005 = Verified data used for regulatory purposes |
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List I; List II | - | - | ||||||||
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Possible bystander risk from spray drift | |||||||||
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Risk of exposure acceptable under label recommendations for use for personal protection clothing and equipment | ||||||||||
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Around 70% of the total dose administered to rats is eliminated in urine within 16hrs | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause pyrexia, cyanosis, pulmonary edema, loss of sphincter control, paralysis, coma and respiratory failure IARC Group 3 carcinogen - not classifiable; US EPA - possible human carcinogen at high doses Endocrine issues - alteration of thyroid function |
Handling issues |
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Not explosive IMDG Transport Hazard Class 9 Not expected to auto-ignite; Not highly flammable |
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Health: H302, H317 Environment: H400, H410 |
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II (Moderately hazardous) | |||
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UN3077 | |||
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Packaging Group III (minor danger) | |||
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trichlorfon | ||
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trichlorfon | ||
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Trichlorfon | ||
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trichlorphon | ||
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triclorfon | ||
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triclorfon | ||
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trichlorfon | ||
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triklorfon | ||
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Record last updated: | 23/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |