Dioxathion (Ref: Hercules AC25) |
Last updated: 28/08/2024 |
(Also known as: dioxation; delnav; dioxane phosphate; dioxationum) |
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An organophosphate compound once used as an insecticide on livestock | |
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Considered obsolete but may be available in some countries | |
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1959, first reported | |
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Once used to control ticks, fleas and mites | |
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Cattle; Goats; Sheep; Pigs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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A chiral molecule. The technical material is an isomeric mixture. | |
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C₁₂H₂₆O₆P₂S₄ | |
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CCOP(=S)(OCC)SC1C(OCCO1)SP(=S)(OCC)OCC | |
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No data | |
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VBKKVDGJXVOLNE-UHFFFAOYSA-N | |
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InChI=1S/C12H26O6P2S4/c1-5-15-19(21,16-6-2)23-11-12(14-10-9-13-11)24-20(22,17-7-3)18-8-4/h11-12H,5-10H2,1-4H3 | |
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Yes |
General status |
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Insecticide | |
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Organophosphate insecticide; Organophosphate acaricide; Organothiophosphate insecticide; Organothiophosphate acaricide | |
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>68% | |
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- | |
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Synthetic | |
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Acetylcholinesterase (AChE) inhibitor. | |
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[Cholinesterase, Inhibitor] | |
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78-34-2 | |
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201-107-7 | |
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124 | |
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037801 | |
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6531 | |
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015-063-00-X | |
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- | |
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None allocated | |
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No | |
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- | |
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456.54 | |
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O,O,O',O'-tetraethyl S,S'-1,4-dioxane-2,3-diyl bis(phosphorodithioate) | |
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S,S'-(1,4-dioxane-2,3-diyl) O,O,O',O'-tetraethyl bis(phosphorodithioate) | |
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S,S'-1,4-dioxane-2,3-diyl bis(O,O-diethyl phosphorodithioate) | |
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Marine Pollutant; Subject to the provisions of the UK Poisons Act 1972 | |
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Reddish-brown liquid |
Formulations |
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1.55 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
Low | ||||||||
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20000 | L3 L = Pesticide manuals and hard copy reference books / other sources Kerosene3 = Unverified data of known source |
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10000 | L3 L = Pesticide manuals and hard copy reference books / other sources n-hexane3 = Unverified data of known source |
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-2 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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2.82 X 1003 | Calculated | - | |||||||
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3.45 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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Soluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Regulatory data - observed in metabolism and farm animal feeding studies | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1.26 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Degradation |
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35 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Moderately persistent | |||||||
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Literature values give DT₅₀ range 15 (silty clay loam) - 55 days (clay) | ||||||||||
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Stable | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
Stable | |||||||
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Stable | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
Stable | |||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
Non-mobile | |||||||
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11845 | ||||||||||
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Estimated | ||||||||||
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Fate indices |
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-0.11 | Calculated | Low leachability | ||||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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23 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
High | ||||||||
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> 3600 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Anas platyrhynchos4 = Verified data |
Low | ||||||||
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> 50 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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0.118 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss4 = Verified data |
Moderate | ||||||||
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0.00035 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
High | ||||||||
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General |
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High (class III) | - | - | ||||||||
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23 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
High | ||||||||
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235 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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0.0015 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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List I; List II | - | - | ||||||||
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May be absorded through the skin - PPE/PPC required | ||||||||||
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Eliminated in faeces and urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause mild transient conjunctivitis Very toxic |
Handling issues |
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Prevent generation of mists | |||
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Health: H300, H311, H330 Environment: H400, H410 |
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Ib (Highly hazardous) | |||
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dioxathion | ||
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dioxathion | ||
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Dioxathion | ||
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dioxation | ||
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dioksation | ||
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Record last updated: | 28/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |