Chlorfenvinphos (Ref: OMS 166) |
Last updated: 23/08/2024 |
(Also known as: clofenvinfos; CVP; OMS 1328; ENT 24969; CGA 26351) |
SUMMARY |
Chlorfenvinphos is a soil-applied insecticide. It has a moderate aqueous solubility and is miscible with many organic solvents. It is relatively volatile and there is some risk that it may leach to groundwater. It is moderately persistent in soil systems. It is highly toxic to mammals, an endocrine disrupter, a neurotoxin and an inhibitor of cholinesterase. In addition, there is some concern that it may bio-concentrate. Chlorfenvinphos is highly toxic to birds, honeybees and aquatic invertebrates. It is moderately toxic to fish and earthworms. |
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An organophosphate antiparasitic used in veterinary medicine for external parasites | |
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Current | |
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circa 1962, introduced | |
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Substance used as a dip or spray to treat ectoparasitic insects, ticks and mites | |
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Sheep; Goats; Cattle |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Exists in two geometric isomeric forms: alpha (cis) isomer and beta (trans) isomer. | |
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C₁₂H₁₄Cl₃O₄P | |
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CCOP(=O)(OCC)OC(=CCl)C1=C(C=C(C=C1)Cl)Cl | |
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CCOP(=O)(OCC)O/C(=C\Cl)/C1=C(C=C(C=C1)Cl)Cl | |
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FSAVDKDHPDSCTO-UHFFFAOYSA-N | |
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InChI=1S/C12H14Cl3O4P/c1-3-17-20(16,18-4-2)19-12(8-13)10-6-5-9(14)7-11(10)15/h5-8H,3-4H2,1-2H3/b12-8- | |
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Yes |
General status |
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Sheep dip, Insecticide | |
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Organophosphate insecticide; Organophosphate acaricide | |
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- | |
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- | |
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Synthetic | |
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Contact and stomach action. Acetylcholinesterase (AChE) inhibitor. | |
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[Cholinesterase, Inhibitor] | |
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470-90-6 | |
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207-432-0 | |
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88 | |
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084101 | |
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5377784 | |
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015-071-00-3 | |
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Antiparasitic products, insecticides & repellents: Ecoparasiticides, insecticides & repellents | |
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QP53 | |
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No | |
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- | |
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359.6 | |
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(1E)-2-chloro-1-(2,4-dichlorophenyl)ethenyl diethyl phosphate | |
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(EZ)-2-chloro-1-(2,4-dichlorophenyl)vinyl diethyl phosphate | |
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2-chloro-1-(2,4-dichlorophenyl)ethenyl diethyl phosphate | |
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WFD priority substance; Marine, Surface and Groundwater Pollutant; Chemical subject to PIC regulations; PAN Bad Actor Chemical; Subject to the provisions of the UK Poisons Act 1972 | |
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EU Directive 2008/105/EC EQS surface waters: annual average 0.1 µg l⁻¹; max measured 0.3 µg l⁻¹ | |
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Colourless to amber liquid |
Formulations |
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145 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Miscible | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Acetone4 = Verified data |
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Miscible | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ethanol4 = Verified data |
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Miscible | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Xylene4 = Verified data |
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Miscible | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Dichloromethane4 = Verified data |
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-20 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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167 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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6.31 X 1003 | Calculated | - | |||||||
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3.8 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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Soluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Regulatory data - observed in metabolism and farm animal feeding studies | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1.36 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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0.0014 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Low volatility | ||||||||
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Degradation |
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40 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
Moderately persistent | |||||||
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37 | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 4 = Verified data |
Moderately persistent | ||||||||
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30 | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 4 = Verified data |
Moderately persistent | ||||||||
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Lab studies DT₅₀ range 6-98 days, field study range 12-45 days; FAO state DT₅₀ 10-45 days | ||||||||||
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125 | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 4 = Verified data |
Persistent | |||||||
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pH and temperature sensitive: DT₅₀ 29 days at pH 1 and 38 °C, 17 days at pH 9 and 38 °C, 1.3 hours at pH 13 and 20 °C, (L3) | ||||||||||
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7 | K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data |
Moderately fast | ||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 5 = Verified data used for regulatory purposes |
Slightly mobile | |||||||
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680 | ||||||||||
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Other literature data Koc 295 mL g⁻¹ (R4) | ||||||||||
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Fate indices |
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1.72 | Calculated | Low leachability | ||||||||||||||||||||||||||
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250 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Threshold for concern | |||||||||||||||||||||||||
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Not available | - |
Known metabolites |
None
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Terrestrial ecotoxicology |
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12 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Rat5 = Verified data used for regulatory purposes |
High | ||||||||
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- | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Rat5 = Verified data used for regulatory purposes |
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3 | - | |||||||||
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80 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Colinus virginianus5 = Verified data used for regulatory purposes |
High | ||||||||
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130 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Moderate | ||||||||
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4.1 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Apis mellifera4 = Verified data |
Moderate | |||||||
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0.55 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Apis mellifera5 = Verified data used for regulatory purposes |
High | ||||||||
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Harmless | AA2 AA = IOBC Database on classification of side effects to beneficial organisms, 2005 Chrysoperla carnea2 = Unverified data of unknown source |
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Harmful | AA2 AA = IOBC Database on classification of side effects to beneficial organisms, 2005 Typhlodromus pyri2 = Unverified data of unknown source |
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Aquatic ecotoxicology |
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1.1 | B3 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Oncorhynchus mykiss3 = Unverified data of known source |
Moderate | ||||||||
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0.03 | Q2 Q = Miscellaneous data from online sources Unknown species2 = Unverified data of unknown source |
Moderate | ||||||||
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0.00025 | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Daphnia magna4 = Verified data |
High | ||||||||
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0.0001 | P3 P = Other non-EU, UK or US Governments and Regulators Daphnia magna3 = Unverified data of known source |
High | ||||||||
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> 0.0003 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ceriodaphnia dubia LC₅₀4 = Verified data |
High | ||||||||
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1.36 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Scenedesmus subspicatus5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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1 | Q2 Q = Miscellaneous data from online sources Unknown species2 = Unverified data of unknown source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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12 | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Rat5 = Verified data used for regulatory purposes |
High | ||||||||
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31 | L3 L = Pesticide manuals and hard copy reference books / other sources Rabbit3 = Unverified data of known source |
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0.05 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 87.0 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ = 87.0 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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List I; List II | - | - | ||||||||
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Dermal and inhalation during pesticide handling Source: US EPA |
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Majority excreted in the urine, much less in the faeces. Some also lost from the lungs. | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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May cause bradycardia or tachycardia May cause Loss of muscle coordination, slurring of speech May cause mental confusion, disorientation and drowsiness Endocrine issues - Weak estrogen effect |
Handling issues |
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Prevent generation of mists Not expected to auto-ignite; Not highly flammable IMDG Transport Hazard Class 6.1 |
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Health: H300, H311 Environment: H400, H410 |
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Ib (Highly hazardous) | |||
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UN3018 | |||
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chlorfenvinphos | ||
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chlorfenviphos | ||
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Chlorfenvinphos | ||
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chlorfenvinphos | ||
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clorfenvinfos | ||
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clorfenvinfos | ||
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chlorfenvinphos | ||
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chlorfenwinfos | ||
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klorfenvinfos | ||
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chloorfenvinfos | ||
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Record last updated: | 23/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |