Benzyl benzoate |
Last updated: 24/10/2024 |
(Also known as: benzoic acid phenylmethyl ester; benzyl phenylformate; benzoic acid benzyl ester; benzylbenzenecarboxylate; benzylis benzoas) |
SUMMARY |
Benzyl benzoate is used mainly as a non-agricultural pesticide although it also has other manufacturing applications. It has a low aqueous solubility and is moderately volatile. Little information is available regarding its environmental fate. Benzyl benzoate is moderately toxic to birds and fish. It has a low oral mammalian toxicity and a neurotoxin as well as being a recognised irritant. |
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A bridged diphenyl insecticide used topically to manage skin problems | |
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Current | |
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Most common use is for the treatment of "Sweet Itch" in horses. It is also sometiems used to treat mites responsible for causing scabies | |
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Horses |
Approval status |
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Approved | |
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Chemical structure |
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None | |
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C₁₄H₁₂O₂ | |
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C1=CC=C(C=C1)COC(=O)C2=CC=CC=C2 | |
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SESFRYSPDFLNCH-UHFFFAOYSA-N | |
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InChI=1S/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H2 | |
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Yes |
General status |
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Antiparasitic | |
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Solvent, Biocide, Disinfectant, Algicide | |
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Bridged diphenyl insecticide | |
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Synthetic | |
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Attacks the nervous system of mites | |
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120-51-4 | |
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204-402-9 | |
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None allocated | |
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009501 | |
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2345 | |
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607-085-00-9 | |
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Antiparasitic products, insecticides & repellents: Ecoparasiticides, insecticides & repellents | |
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QP53AX11 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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212.25 | |
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benzyl benzoate | |
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benzyl benzoate | |
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phenylmethyl benzoate | |
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Colourless to pale yellow oily liquid with pleasant aromatic odour |
Formulations |
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Killitch 25% w/v cutaneous emulsion | Carr Day and Martin Ltd | UK National authorisation | Authorised veterinary medicine for general sale (AVM-GSL) | ||||||
Savlon Veterinary Antiseptic concentrate | Schering-Plough Ltd | Not licensed | Not licensed | |||||||
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Often supplied as lotions for topical administration |
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15.4 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
Low | ||||||||
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Miscible | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Ether5 = Verified data used for regulatory purposes |
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Miscible | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Ethanol5 = Verified data used for regulatory purposes |
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Miscible | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Methanol5 = Verified data used for regulatory purposes |
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Miscible | B5 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Acetone5 = Verified data used for regulatory purposes |
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18 | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 4 = Verified data |
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323 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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158 | E3 E = Manufacturers safety data sheets (closed cup)3 = Unverified data of known source |
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9.33 X 1003 | Calculated | - | |||||||
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3.97 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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1.12 | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) 4 = Verified data |
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29.86 | V2 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 2 = Unverified data of unknown source |
Highly volatile. If applied directly to plants or soil, drift is a concern & mitigation is advisable | ||||||||
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0.284 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderately volatile | ||||||||
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1.5681 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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benzoic acid | - | Human | - | ||||
benzyl alcohol | - | Human | - | ||||
hippuric acid | - | Human | - |
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Terrestrial ecotoxicology |
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> 2800 | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Rat4 = Verified data |
Low | ||||||||
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2000 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Colinus virginianus3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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4.6 | E3 E = Manufacturers safety data sheets Unknown species3 = Unverified data of known source |
Moderate | ||||||||
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General |
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Low (class I) | - | - | ||||||||
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> 2800 | B4 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Rat4 = Verified data |
Low | ||||||||
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2000 | B3 B = UK CRD and ACP Evaluation Documents / and other DEFRA (UK) documents; Also Chemicals Regulation Division, Health and Safety Executive (HSE), UK (click here ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ > 500 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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No unacceptable risks identified | |||||||||
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May be absorbed through the skin | ||||||||||
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Metabolised and excreted mainly in the urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause nausea and vomiting In large doses may cause skin blistering, crusting & scaling |
Handling issues |
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Combustible IMDG Transport Hazard Class 9 Incompatible with alkalis and oxidising agents |
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Health: H302 Environment: H411 |
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Not listed (Not listed) | |||
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UN3082 | |||
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Packaging Group III (minor danger) | |||
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benzyl benzoate | ||
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Record last updated: | 24/10/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |