Flumequine |
Last updated: 09/01/2024 |
(Also known as: R-802; Apurone) |
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A first generation fluoroquinolone antibiotic and microbiocide active against gram negative bacteria | |
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Used mainly to treat enteric infections | |
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Farmed livestock; Domestic pets; Fish; Poultry |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₄H₁₂FNO₃ | |
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CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2)F)C(=O)O | |
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No data | |
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DPSPPJIUMHPXMA-UHFFFAOYSA-N | |
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InChI=1S/C14H12FNO3/c1-7-2-3-8-4-9(15)5-10-12(8)16(7)6-11(13(10)17)14(18)19/h4-7H,2-3H2,1H3,(H,18,19) | |
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Yes |
General status |
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Microbiocide, Antibiotic, Antibacterial | |
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Quinolone drug | |
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Synthetic | |
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Broad spectrum, fluoroquinolones inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, resulting the inhibition of DNA replication and transcription. | |
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[DNA gyrase subunit A, Antagonist] | |
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42835-25-6 | |
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255-962-6 | |
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Antiinfectants for system use: Antibacterials for systemic use | |
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QJ01MB07 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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261.25 | |
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9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]-quinolizine-2-carboxylic acid | |
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White crystalline powder | |
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Formulations |
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Flumisol Oral Solution 100mg/ml | Ceva Animal Health Ltd | Not licensed | Not licensed | ||||||
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2190 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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254 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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3.63 X 1002 | Calculated | - | |||||||
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2.56 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
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6.21 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Weak acid | |||||||||||
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0.033 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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2.71 X 10-18 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Non-volatile | ||||||||
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Degradation |
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150 | R2 R = Peer reviewed scientific publications 2 = Unverified data of unknown source |
Persistent | |||||||
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DT₅₀ value for surface sediment | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | V1 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 1 = Estimated data with little or no verification |
Moderately mobile | |||||||
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180 | ||||||||||
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Estimated | ||||||||||
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Fate indices |
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3.80 | Calculated | High leachability | ||||||||||||||||||||||||||
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Known soil and groundwater metabolites |
None
Other known metabolites |
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7-hydroxy-flumequine | - | Ruminants (Faeces) | - |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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10 | R4 R = Peer reviewed scientific publications Pimephales promelas4 = Verified data |
Moderate | ||||||||
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10 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Moderate | ||||||||
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2.4 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Lemna minor4 = Verified data |
Moderate | ||||||||
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5.0 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Pseudokirchneriella subcapitata4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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Occupational exposure to flumequine may occur through inhalation and dermal contact | ||||||||||
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In mammals it is well absorbed and is excreted in the urine and faeces | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible liver toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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flumequine | ||
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fluméquine | ||
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Fluméquine | ||
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flumequino | ||
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Record last updated: | 09/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |