Nitenpyram (Ref: CGA 246916) |
Last updated: 24/07/2024 |
(Also known as: (E)-nitenpyram ; TI 204; niterndipoine) |
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A systemic insecticide used mainly to kill external parasites in livestock and domestic pets | |
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Current | |
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1989 discovered, 1995 launched | |
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Mainly used to treat adult flea infestations in mammals and maggot infestations on reptiles as off-label | |
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Cats; Dogs; Reptiles |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric - molecule has one E/Z centre | |
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C₁₁H₁₅ClN₄O₂ | |
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CCN(CC1=CN=C(C=C1)Cl)C(=C[N+](=O)[O-])NC | |
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CCN(CC1=CN=C(C=C1)Cl)/C(=C/[N+](=O)[O-])/NC | |
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CFRPSFYHXJZSBI-DHZHZOJOSA-N | |
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InChI=1S/C11H15ClN4O2/c1-3-15(11(13-2)8-16(17)18)7-9-4-5-10(12)14-6-9/h4-6,8,13H,3,7H2,1-2H3/b11-8+ | |
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Yes |
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Common Name | Relationship | Link |
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nitenpyram | - |
General status |
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Insecticide, Antiparasitic | |
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Neonicotinoid insecticide | |
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>98% | |
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- | |
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Semi-synthetic | |
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Systemic with translaminar activity, stomach and contact action affecting insects nervous system. No long term activity. Nicotinic acetylcholine receptor (nAChR) channel blocker. | |
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[Nicotinic acetylcholine receptors, Binder] | |
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150824-47-8 | |
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634-900-5 | |
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None allocated | |
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- | |
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3034287 | |
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No data found | |
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Antiparasitic products, insecticides & repellents: Ecoparasiticides, insecticides & repellents | |
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QP53BX02 | |
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No | |
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- | |
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270.72 | |
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(1E)-N-[(6-chloropyridin-3-yl)methyl]-N-ethyl-N'-methyl-2-nitroethene-1,1-diamine | |
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(E)-N-(6-chloro-3-pyridylmethyl)-N-ethyl-N'-methyl-2-nitrovinylidenediamine | |
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(1E)-N-[(6-chloro-3-pyridinyl)methyl]-N-ethyl-N'-methyl-2-nitro-1,1-ethenediamine | |
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PAN listed Highly Hazardous Chemical | |
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- | |
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Pale yellow to orange crystalline solid |
Formulations |
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Bob Martin Flea Tablets | Elanco Europe Ltd | UK National authorisation (IC) | Authorised veterinary medicine for general sale (AVM-GSL) | ||||||
Capstar 11.4mg Tablets for Cats and Small Dogs | Elanco Europe Ltd | GB National authorisation | Authorised veterinary medicine for general sale (AVM-GSL) | |||||||
Johnsons 4Fleas 57mg Tables for Dogs | Elanco Europe Ltd | UK National authorisation (IC) | Authorised veterinary medicine for general sale (AVM-GSL) | |||||||
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Usually supplied in tablet form for oral administration |
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570000 | E4 E = Manufacturers safety data sheets 4 = Verified data |
High | ||||||||
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1000000 | L3 L = Pesticide manuals and hard copy reference books / other sources Methanol3 = Unverified data of known source |
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700000 | L3 L = Pesticide manuals and hard copy reference books / other sources Chloroform3 = Unverified data of known source |
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290000 | L3 L = Pesticide manuals and hard copy reference books / other sources Acetone3 = Unverified data of known source |
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4500 | L3 L = Pesticide manuals and hard copy reference books / other sources Xylene3 = Unverified data of known source |
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72 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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417.2 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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2.19 X 10-01 | Calculated | - | |||||||
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-0.66 | L3 L = Pesticide manuals and hard copy reference books / other sources at 25 °C3 = Unverified data of known source |
Low | ||||||||
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1.254 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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3.1 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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0.0011 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Low volatility | ||||||||
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3.54 X 10-13 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Non-volatile | ||||||||
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Degradation |
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8 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Non-persistent | |||||||
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General literature states DT₅₀ 1-15 days | ||||||||||
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Stable | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Stable | |||||||
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Stable pH 3-7 at 25 °C; pH9 DT₅₀ = 2.9 days | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
Mobile | |||||||
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60 | ||||||||||
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Estimated | ||||||||||
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Fate indices |
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2.01 | Calculated | Transition state | ||||||||||||||||||||||||||
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
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- | - |
Known soil and groundwater metabolites |
None
Other known metabolites |
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2-(N-(6-chloro-3-pyridylmethyl)-N-ethyl-N-methylformamidine | 3-CPMF | Plant | - | ||||
2-(N-(6-chloro-3-pyridylmethyl)-N-ethyl)amino-2-methyliminoacetic acid | 2-CPMA | Plant | - |
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Terrestrial ecotoxicology |
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1575 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
Moderate | ||||||||
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1124 | L3 L = Pesticide manuals and hard copy reference books / other sources Anas platyrhynchos3 = Unverified data of known source |
Moderate | ||||||||
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32.2 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Moderate | ||||||||
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0.138 | R4 R = Peer reviewed scientific publications 4 = Verified data |
High | ||||||||
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> 0.33 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Chrysoperla carnea Larva4 = Verified data |
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Aquatic ecotoxicology |
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10 | L3 L = Pesticide manuals and hard copy reference books / other sources Oncorhynchus mykiss3 = Unverified data of known source |
Moderate | ||||||||
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10000 | L3 L = Pesticide manuals and hard copy reference books / other sources Daphnia magna3 = Unverified data of known source |
Low | ||||||||
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26 | L3 L = Pesticide manuals and hard copy reference books / other sources Pseudokirchneriella subcapitata3 = Unverified data of known source |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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1575 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
Moderate | ||||||||
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2000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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5.8 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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In mammals it is excreted mostly unchanged in the urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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No further information available |
Handling issues |
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Corrosive | |||
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Health: H302, H315, H319, H335 Environment: H400, H410 |
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II (Moderately hazardous) | |||
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Limited shelf-life. Store at -20 DegC |
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nitenpyram | ||
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Record last updated: | 24/07/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |