Sarafloxacin |
Last updated: 09/02/2024 |
(Also known as: difloxacine; difloxacin) |
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A second generation fluoroquinolone antibiotic and antimicrobial veterinary medicine | |
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1995, first approved in US | |
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Used to treat a wide range of bacterial infections including those of the respiratory tract, urinary system and skin tissue | |
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Poultry; Fish; Pigs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₂₀H₁₇F₂N₃O₃ | |
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C1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F | |
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No data | |
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XBHBWNFJWIASRO-UHFFFAOYSA-N | |
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InChI=1S/C20H17F2N3O3/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24/h1-4,9-11,23H,5-8H2,(H,27,28) | |
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Yes |
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Common Name | Relationship | Link |
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sarafloxacin trihydrate | Trihydrate |
General status |
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Antibiotic, Antimicrobial | |
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Fluoroquinolone | |
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Synthetic | |
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Inhibition of bacterial DNA-gyrase | |
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[DNA gyrase subunit A, Antagonist] | |
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98105-99-8 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01MA94 | |
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No | |
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Allowed substance (Table 1: Chicken, Salmonidae) | |
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385.36 | |
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- | |
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6-fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid | |
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6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinolinecarboxylic acid | |
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White to yellow coloured crystalline solid |
Formulations |
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100 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderate | ||||||||
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275 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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1.66 X 1002 | Calculated | - | |||||||
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2.22 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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6.15 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Degradation |
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70 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Moderately persistent | |||||||
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General literature states DT₅₀ range 65-80 days | ||||||||||
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0.05 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Fast | |||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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1380 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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1000 | R4 R = Peer reviewed scientific publications Eisenia foetida4 = Verified data |
Low | ||||||||
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Aquatic ecotoxicology |
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16 | R3 R = Peer reviewed scientific publications Pseudokirchneriella subcapitata3 = Unverified data of known source |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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1380 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Mainly excreted in faeces (~79%) with the remainder lost in urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible liver and kidney toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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sarafloxacin | ||
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sarafloxacino | ||
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sarafloxacine | ||
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Record last updated: | 09/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |