Sulphachlorpyridazine |
Last updated: 17/05/2024 |
(Also known as: sulfachlorpyridazine; BA-10370) |
|
|
An antibacterial / antibiotic veterinary medicine used to control a range of infections | |
---|---|---|
|
Current | |
|
- | |
|
Used to treatr urinary tract and other bacterial infections | |
|
Pigs; Poultry; Calves |
Approval status |
|
Not approved | |
---|---|---|
|
Not approved |
Chemical structure |
|
- | |
---|---|---|
|
C₁₀H₉ClN₄O₂S | |
|
C1=CC(=CC=C1N)S(=O)(=O)NC2=NN=C(C=C2)Cl | |
|
No data | |
|
XOXHILFPRYWFOD-UHFFFAOYSA-N | |
|
InChI=1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15) | |
|
Yes |
|
Common Name | Relationship | Link |
---|---|---|
sulphachlorpyridazine | - |
General status |
|
Antibiotic, Microbiocide, Antimicrobial, Antibacterial | |
---|---|---|
|
Sulfonamide | |
|
- | |
|
- | |
|
Synthetic | |
|
Inhibits folic acid synthesis in prokaryotes | |
|
[Dihydropteroate synthase, Inhibitor] | |
|
80-32-0 | |
|
201-269-9 | |
|
- | |
|
- | |
|
- | |
|
Antiinfectants for systemic use: Antibacterials for systemic use | |
|
QJ01EW12 | |
|
No | |
|
Allowed substance (Table 1: All food producing species) | |
|
284.72 | |
|
- | |
|
4-amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide | |
|
4-amino-N-(6-chloro-3-pyridazinyl)benzenesulfonamide | |
|
- | |
|
- | |
|
- | |
|
Formulations |
|
|
|
|
|
||||||
---|---|---|---|---|---|---|---|---|---|---|
|
Cosumix Plus powder for oral solution | Novartis Animal Health Ltd | Not licensed | Not licensed | ||||||
|
- |
|
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
7000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
|
- | - | - | ||||||||
|
187 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
- | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
2.04 X 1000 | Calculated | - | |||||||
|
0.31 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
1.40 | R4 R = Peer reviewed scientific publications 4 = Verified data |
- | ||||||||
- | |||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- |
Degradation |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
17 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Non-persistent | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
General literature states DT₅₀ range 3.5-21 days | ||||||||||
|
<8.0 | R4 R = Peer reviewed scientific publications Slightly persistent; Other data 127 days for slurry4 = Verified data |
- | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
|
- |
Soil adsorption and mobility |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
- | R4 R = Peer reviewed scientific publications 4 = Verified data |
Mobile | |||||||
|
43 | ||||||||||
|
General literature states Koc range 3.3-82 mL g⁻¹ | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | ||||||||||
|
- | ||||||||||
|
- |
Fate indices |
|
|
|
|
||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
2.91 | Calculated | High leachability | ||||||||||||||||||||||||||
|
|
- | - | - | |||||||||||||||||||||||||
|
- | - |
Known metabolites |
None
|
Terrestrial ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | |||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
- | - | - | |||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
- | |||||||||||
|
- | - | - | ||||||||
- | |||||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - |
Aquatic ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
535.7 | R4 R = Peer reviewed scientific publications Oryzias latipes4 = Verified data |
Low | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
0.375 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Moderate | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - |
|
- | - | - |
|
General |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
High (class III) | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | |||||||||
|
- | ||||||||||
|
Elimination may occur in the urine, bile, feces, sweat, tears, or milk | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
- |
Health issues |
|
|
||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ingestion of sulfonamide can cause nausea, vomiting & diarrhoea Possible kidney, gastrointestinal & liver toxicant |
Handling issues |
|
|
|||
---|---|---|---|---|
|
Light sensitive | |||
|
- | |||
|
Not listed (Not listed) | |||
|
- | |||
|
- | |||
|
- |
|
|
|
||
---|---|---|---|
|
sulphachlorpyridazine | ||
|
sulfachlorpyridazine | ||
|
Sulfachlorpyridazine | ||
|
- | ||
|
- | ||
|
sulfacloropiridazina | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- |
Record last updated: | 17/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |