Meloxicam |
Last updated: 18/05/2024 |
(Also known as: meloxicamum; metacam) |
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A non-steroidal anti-inflammatory drug (NSAID) used for anti-inflammatory and analgesic purposes in veterinary care | |
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Current | |
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Circa 1995, introduced; 1998, first veterinary approval | |
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Generally used before surgery to control pain and inflammation after spays, neuters, and orthopedic surgeries | |
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Dogs; Cats; Pigs; Cattle; Vultures |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₁₄H₁₃N₃O₄S₂ | |
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CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O | |
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No data | |
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ZRVUJXDFFKFLMG-UHFFFAOYSA-N | |
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InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19) | |
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Yes |
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Common Name | Relationship | Link |
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meloxicam | - |
General status |
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Medicinal drug, Anti-inflammatory, Analgesic | |
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Oxicam derivative | |
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96% | |
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Synthetic | |
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Inhibits prostaglandin synthesis thereby exerting an anti-inflammatory, analgesic, anti-exudative and antipyretic effect | |
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[Prostaglandin G/H synthase 2, Antagonist], [Prostaglandin G/H synthase 1, Antagonist] | |
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71125-38-7 | |
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Musculo-skeletal system: Anti-inflammatory & antirheumatic products | |
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QM01AC06 | |
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No | |
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Allowed substance (Table 1: Bovine, Caprine, Porcine, Rabbit, Equidae) | |
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351.40 | |
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4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide | |
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2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methylthiazolyl)-, 1,1-dioxide | |
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Pale yellow powder |
Formulations |
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Animeloxan Oral Suspension | aniMedica GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Chanoxidxyl Oral Suspension | EU Pharmaceuticals Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Loxicom Oral Suspension for Dogs | Norbrook Laboratories Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Metaxx Chewable Tablets | Alfasan Nederland B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Often formulated as oral suspensions and solutions for injection |
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7.15 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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254 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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2.69 X 1003 | Calculated | - | |||||||
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3.43 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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3.8 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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pka(2) = 7.6 | |||||||||||
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1.42 X 10-10 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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No absorption >290 nm | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | V1 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 1 = Estimated data with little or no verification |
Slightly mobile | |||||||
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1700 | ||||||||||
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Estimated | ||||||||||
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Fate indices |
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85 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low potential | |||||||||||||||||||||||||
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Not available | - |
Known soil and groundwater metabolites |
None
Other known metabolites |
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5'-carboxy meloxicam Note: Pharmacologically inactive |
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5'-hydroxymethyl meloxicam Note: Pharmacologically inactive |
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Terrestrial ecotoxicology |
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> 83.5 | R4 R = Peer reviewed scientific publications Rat4 = Verified data |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 83.5 | R4 R = Peer reviewed scientific publications Rat4 = Verified data |
High | ||||||||
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Occupational exposure to meloxicam may occur through inhalation and dermal contact | ||||||||||
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Almost completely metabolised and excreted as breakdown products in the urine and faeces. The mean elimination half-life (t1/2) ranges from 15 hours to 20 hours. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause gastrointestinal toxicity and bleeding, tinnitus &/or headaches Possible kidney, liver & blood toxicant May cause dermatitis or other skin problems |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group III (minor danger) | |||
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meloxicam | ||
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meloxicam | ||
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meloxicam | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |