Moxidectin (Ref: CL 301423) |
Last updated: 26/04/2024 |
(Also known as: milbemycin B) |
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A semi-synthetic, broad spectrum veterinary antiparasitic treatment | |
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Current | |
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1990, synthesised | |
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Used for the prevention and control of heartworm and intestinal worms | |
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Dogs; Cats; Horses; Cattle; Sheep |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Moxidectin is the 23-E isomer of the 23-methoxime derivative of nemadectin | |
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C₃₇H₅₃NO₈ | |
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CC1CC(=CCC2CC(CC3(O2)CC(=NOC)C(C(O3)C(=CC(C)C)C)C)OC(=O)C4C=C(C(C5C4(C(=CC=C1)CO5)O)O)C)C | |
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C[C@@H]\1C/C(=C/C[C@@H]2C[C@@H](C[C@@]3(O2)C/C(=N\OC)/[C@@H](C(O3)/C(=C/C(C)C)/C)C)OC(=O)[C@@H]4C=C([C@H]([C@@H]5[C@]4(/C(=C/C=C1)/CO5)O)O)C)/C | |
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YZBLFMPOMVTDJY-BFPKLJSTSA-N | |
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InChI=1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31+/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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moxidectin | - |
General status |
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Insecticide, Acaricide, Antiparasitic, Ectoparasiticide | |
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A milbemycin | |
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Semi-synthetic | |
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Selectively binds to the parasites glutamate-gated chloride ion channels | |
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[Glycine receptor subunit alpha-3, Agonist], [Gamma-aminobutyric-acid (GABA) receptor subunit beta-3, agonist] | |
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113507-06-5 | |
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9832912 | |
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Antiparasitic products, insecticides & repellents: Endectocides | |
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QP54AB02 | |
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No | |
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Allowed substance (Table 1: Bovine, Ovine) | |
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639.82 | |
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- | |
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(10E,14E,16E)-(1R,4S,5'S,6R,6'S,8R,13R,20R,21R,24S)-6'-[(1E)-1,3-dimethylbut-1-enyl]-21,24-dihydroxy-5',11,13,22-tetramethyl-(3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene)-6-spiro-2'-(tetrahydropyran)-2,4'-dione 4'-(E)-(O-methyloxime) | |
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(6R,23E,25S)-5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)milbemycin B | |
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- | |
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- | |
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White to pale yellow powder |
Formulations |
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Advocate Spot-on Solution | Bayer Animal health | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Bravecto Plus Spot-on Solution | MSD Animal Health UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Moxiclear Spot-on Solution | Norbrook Laboratories Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Simparica Trio Chewable Tablets | Zoetis UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated for topical appliactions such as spot-on and pour-on products |
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0.51 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Low | ||||||||
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610000 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Dichloromethane3 = Unverified data of known source |
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125000 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ethanol3 = Unverified data of known source |
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145 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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5.89 X 1004 | Calculated | - | |||||||
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4.77 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
High | ||||||||
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Max at 245nm, only slight absorption above 300nm | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Degradation |
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62 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderately persistent | |||||||
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0.3 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | R4 R = Peer reviewed scientific publications 4 = Verified data |
Non-mobile | |||||||
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29500 | ||||||||||
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General literature Koc range 18000-41000 mL g⁻¹ | ||||||||||
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Fate indices |
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-0.84 | Calculated | Low leachability | ||||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 106 | R4 R = Peer reviewed scientific publications Rat4 = Verified data |
Moderate | ||||||||
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278 | R3 R = Peer reviewed scientific publications Colinus virginianus3 = Unverified data of known source |
Moderate | ||||||||
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37.2 | R3 R = Peer reviewed scientific publications Eisenia foetida3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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0.00016 | R4 R = Peer reviewed scientific publications Oncorhynchus mykiss4 = Verified data |
High | ||||||||
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< 0.00015 | R3 R = Peer reviewed scientific publications Oncorhynchus mykiss 96 hour3 = Unverified data of known source |
High | ||||||||
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0.00003 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
High | ||||||||
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0.087 | R3 R = Peer reviewed scientific publications Green algae3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 106 | R4 R = Peer reviewed scientific publications Rat4 = Verified data |
Moderate | ||||||||
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2000 | R4 R = Peer reviewed scientific publications Rabbit4 = Verified data |
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Majority of dose is excreted in faeces. Also identified in milk. The depletion half-lives in fat, muscle and kidney/liver were 11.5, 3.9 and 2.4 days, respectively. | V4 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 4 = Verified data |
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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moxidectin | ||
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moxidectine | ||
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moxidectina | ||
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Record last updated: | 26/04/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |