Oxfendazole (Ref: HOE 8105) |
Last updated: 14/02/2024 |
(Also known as: OFDZ; RS-8858) |
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A benzimidazole anthelmintic active against both adults and laval stages of parasitic worms | |
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Current | |
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circa 1980, registered for veterinary use USA | |
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Used for the management roundworms, strongyles and pinworms | |
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Sheep; Cattle; Goats; Pigs; Horses |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₁₅H₁₃N₃O₃S | |
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COC(=O)NC1=NC2=C(N1)C=C(C=C2)S(=O)C3=CC=CC=C3 | |
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No data | |
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BEZZFPOZAYTVHN-UHFFFAOYSA-N | |
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InChI=1s/C15H13N3O3S/c1-21-15(19)18-14-16-12-8-7-11(9-13(12)17-14)22(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19) | |
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Yes |
General status |
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Anthelmintic, Antiparasitic | |
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Benzimidazole | |
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Synthetic | |
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Inhibits tubulin synthesis in the parasite and leading to death by starvation. | |
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[Tubulin beta chain, Antagonist] | |
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53716-50-0 | |
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258-714-5 | |
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Antiparasitic products, insecticides & repellents: Anthelmintics | |
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QP52AC02 | |
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No | |
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Allowed substance (Table 1: Ruminants, Porcine, Equidae) | |
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315.35 | |
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(5-(phenylsulfinyl)-1H-benzimidazol-2-yl)carbamic acid methyl ester | |
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methyl-5-(phenylsulfinyl) benzimidazole-2-carbamate | |
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- | |
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- | |
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White to off-white powder |
Formulations |
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Autoworm Finisher | Zoetis UK Ltd | UK National authorisation (IC) | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Autoworm First Grazer Pulsatile-Release Intraruminal Device | Zoetis UK Ltd | UK National authorisation (IC) | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Bovex Oral Suspension | Chanelle Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Ovidown SC Oral Suspension | Norbrook Laboratories Ltd | UK National authorisation (IC) | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Currently available formulations include pulsatile-release intraruminal devices and liquid suspensions for oral administration |
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3.11 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Low | ||||||||
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245 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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8.91 X 1001 | Calculated | - | |||||||
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1.95 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Main environmental release is via the slurry and manure from treated livestock |
Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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8.87 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Slightly mobile | |||||||
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885 | ||||||||||
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USEPA data: Kd range 3.87-16.73 mL g⁻¹, Koc range 470-1673 mL g⁻¹, Soils=3 | ||||||||||
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8.87 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Slightly mobile | |||||||
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887 | ||||||||||
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0.9 | ||||||||||
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USEPA data: Kf range 4.5-15.7 mL g⁻¹, Kfoc range 544-1570 mL g⁻¹, 1/n range 0.87-0.93, Soils=3 | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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2-amino-5(6)-phenylsulfinyl benzimidazole | oxfendazole amine | Hydrolysis | - |
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Terrestrial ecotoxicology |
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> 6400 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat4 = Verified data |
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> 971 | R4 R = Peer reviewed scientific publications Eisenia foetida4 = Verified data |
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Aquatic ecotoxicology |
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> 2.7 | R4 R = Peer reviewed scientific publications Lepomis macrochirus4 = Verified data |
Moderate | ||||||||
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> 5.6 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio EC₅₀ Embryo3 = Unverified data of known source |
Moderate | ||||||||
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1.17 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 6400 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat4 = Verified data |
Low | ||||||||
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Metabolised to active oxfendazole sulfoxide and sulfone. Excreted mainly in faeces. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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oxfendazole | ||
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oxfendazole | ||
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oxfendazol | ||
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Record last updated: | 14/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |