Cyanocobalamin |
Last updated: 02/05/2024 |
(Also known as: vitamin B12; anacobin) |
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A human and veterinary drug used a vitamin supplement | |
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Current | |
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1955, introduced | |
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Substance used to treat cobalt deficiencies in livestock principally sheep | |
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Sheep; Cattle; Horses; Pigs; Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₆₃H₈₈CoN₁₄O₁₄P | |
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CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3] | |
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CC1=CC2=C(C=C1C)N(C=N2)[C@@H]3[C@@H]([C@@H]([C@H](O3)CO)OP(=O)([O-])O[C@H](C)CNC(=O)CC[C@@]4([C@H]([C@@H]5[C@]6([C@@]([C@@H](/C(=C(/C7=N/C(=C\C8=N/C(=C(\C4=N5)/C)/[C@H](C8(C)C)CCC(=O)N)/[C@H]([C@]7(C)CC(=O)N)CCC(=O)N)\C)/[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3] | |
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FDJOLVPMNUYSCM-WZHZPDAFSA-L | |
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InChI=1S/C62H88N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,57,76,84H,12-19,22,24-27H2,1-11H3,(H2,63,77)(H2,64,78)(H2,65,79)(H2,66,80)(H2,67,81)(H2,68,82)(H,69,83)(H,85,86);;/q;;+1/p-1/b42-23-,54-32-,55-33-;; | |
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Yes |
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Common Name | Relationship | Link |
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cyanocobalamin hydrate | - |
General status |
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Medicinal drug | |
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Unclassifed substance | |
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Natural | |
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Converted to coenzyme B12 that is vital for a number of body processes including growth, hematopoiesis and nucleoprotein and myelin synthesis. | |
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[Methionine synthase], [Methylmalonyl-CoA mutase, mitochondrial], [Methionine synthase reductase, mitochondrial], [Methylmalonic aciduria type A protein, mitochondrial], [Methylmalonic aciduria and homocystinuria type C protein], [Amnionless protein], [Transcobalamin-1], [Transcobalamin-2], [Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial], [Cubilin] | |
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68-19-9 | |
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200-680-0 | |
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166596686 | |
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Blood & blood forming organs: Antianemic preparations | |
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QB03BA01 | |
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No | |
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Not applicable - vitamin | |
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1355.38 | |
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5,6-dimethylbenzimidazolylcobamide cyanide | |
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5,6-dimethyl-benzimidazolyl cyanocobamide | |
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Dark red to brown hygroscopic crystalline solid |
Formulations |
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Butasal Solution for injection | Interchemie Werken De Adelaar Eesti AS | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Vigophos Solution for Injection | Livisto International SA | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Vitbee Solution for injection | Alfasan Nederland B.V. | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Usually formulated as a solution for Injection |
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12500 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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102.5 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Decomposes before boiling | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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3.72 X 1003 | Calculated | - | |||||||
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3.57 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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In water max at: 278nm, 361nm & 55nm | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 5000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 5000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
Low | ||||||||
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Intraperitoneal LDLo = 1.36 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ > 2000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Rapidly excreted in the urine and faeces but also identified in human breast milk and bile | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Generally considered to be non-toxic May lead to allergic reactions May cause breathing difficulties |
Handling issues |
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Use water spray, fog or foam to fight fires. Do not use water jet | |||
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Not listed (Not listed) | |||
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cyanocobalamin | ||
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cyanocobalamine | ||
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cianocobalamina | ||
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Record last updated: | 02/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |