Lasalocid sodium |
Last updated: 07/02/2024 |
(Also known as: lasalocid A) |
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A divalent polyether ionophore antibiotic and antiparasitic veterinary drug used to control gram-positive bacteria | |
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1951, first reported | |
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Used as a feed supplement for fattening game birds and cattle; Also used for the prevention of coccidiosis caused by Eimeria spp. in game birds. | |
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Turkeys; Chickens; Game birds; Sheep; Cattle |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₃₄H₅₃O₈Na | |
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CCC(C1C(CC(O1)(CC)C2CCC(C(O2)C)(CC)O)C)C(=O)C(C)C(C(C)CCC3=C(C(=C(C=C3)C)O)C(=O)[O-])O.[Na+] | |
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CC[C@H]([C@@H]1[C@H](C[C@@](O1)(CC)[C@H]2CC[C@@]([C@@H](O2)C)(CC)O)C)C(=O)[C@@H](C)[C@H]([C@H](C)CCC3=C(C(=C(C=C3)C)O)C(=O)[O-])O.[Na+] | |
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RDHDUYAKDYQPEW-HWLWSTNVSA-M | |
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InChI=1S/C34H54O8.Na/c1-9-25(31-21(6)18-34(11-3,42-31)26-16-17-33(40,10-2)23(8)41-26)30(37)22(7)28(35)19(4)12-14-24-15-13-20(5)29(36)27(24)32(38)39;/h13,15,19,21-23,25-26,28,31,35-36,40H,9-12,14,16-18H2,1-8H3,(H,38,39);/q;+1/p-1 | |
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Yes |
General status |
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Antibiotic, Medicinal drug, Feed additive, Coccidiostat, Antiparasitic | |
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Ionophore | |
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97% | |
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Synthetic | |
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Dissociates the calcium fluxes in muscle fibres. Lasalocid sodium disturbs ionic homeostasis, leading to osmotic lysis of coccidia. | |
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[Ionic homeostasis, Antagonist] | |
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25999-20-6 | |
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247-400-3 | |
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Antiparasitic products, insecticides & repellents: Antiprotozoals | |
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QP51AH02 | |
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No | |
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Allowed substance (Table 1: Poultry) | |
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612.77 | |
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(2R-(2α(2S*(3R*,4S*,5S*,7R*),3S*,5S*),5α,6β))-6-(7-(5-Ethyl-5-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)tetrahydro-3-methyl-2-furanyl)-4-hydroxy-3,5-dimethyl-6-oxononyl)-2-hydroxy-3-methylbenzoic acid monosodium salt | |
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Benzoic acid, 6-(3R,4S,5S,7R)-7-(2S,3S,5S)-5-ethyl-5-(2R,5R,6S)-5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yltetrahydro-3-methyl-2-furanyl-4-hydroxy-3,5-dimethyl-6-oxononyl-2-hydroxy-3-methyl-, monosodium salt | |
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White to brown coloured powder |
Formulations |
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Avatec 150 G 150 mg/g premix for medicated feed | Alpharma Animal Health BVBA | Not licensed | Not licensed | ||||||
Bovatec 150 Premix | Alpharma Animal Health Pty Ltd | Not licensed | Not licensed | |||||||
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Often used as medicated pre-mix feed |
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50 | F2 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 2 = Unverified data of unknown source |
Moderate | ||||||||
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10000 | Q3 Q = Miscellaneous data from online sources Methanol3 = Unverified data of known source |
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180 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.00 X 102255 | Calculated | - | |||||||
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225 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
High | ||||||||
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1.119 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderately mobile | |||||||
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323 | ||||||||||
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Koc value is for the acid | ||||||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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122 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 59 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Gallus domesticus5 = Verified data used for regulatory purposes |
High | ||||||||
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Aquatic ecotoxicology |
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3.0 | E3 E = Manufacturers safety data sheets Oncorhynchus mykiss3 = Unverified data of known source |
Moderate | ||||||||
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3.6 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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2.4 | E3 E = Manufacturers safety data sheets Scenedesmus subspicatus3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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122 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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1400 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rabbit5 = Verified data used for regulatory purposes |
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Intraperitoneal LD₅₀ = 64 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Widespread distribution throughout the body once administered. Blood elimination DT50 is ~3hrs in rats. Almost totally excreted by the biliary duct. | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Toxic to humans, horses and other species - has low margin of safety Poison by ingestion and intraperitoneal routes |
Handling issues |
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When heated to decomposition it emits acrid smoke and irritating fumes IMDG Transport Hazard Class 6.1(b) |
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group III (minor danger) | |||
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lasalocid sodium | ||
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lasalocide sodique | ||
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lasalocido sodico | ||
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Record last updated: | 07/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |