Benazepril hydrochloride (Ref: CGS 14824A) |
Last updated: 25/01/2024 |
(Also known as: benazepril HCl ) |
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A phenylpropylamine medicinal prodrug which is a second generation ACE inhibitor | |
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Current | |
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1981, patented; 1990, first medical use | |
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Used to treat congestive heart failure, high blood pressure and chronic renal failure | |
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Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₄H₂₉N₂O₅Cl | |
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CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl | |
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CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl | |
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VPSRQEHTHIMDQM-FKLPMGAJSA-N | |
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InChI=1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1 | |
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Yes |
General status |
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Medicinal drug, Hypertensive agent, Prodrug | |
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Phenylpropylamine | |
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>99% | |
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Synthetic | |
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A second generation ACE (angiotensin-converting enzyme) inhibitor which prevents the catalytic conversion of angiotensin I to angiotensin II and in turn causes vasodilation and an increase in capillary blood volume | |
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[Angiotensin-converting enzyme, Antagonist] | |
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86541-74-4 | |
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5362123 | |
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Alimentary tract & metabolism: Agents acting on the renin-angiotensin system; ACE inhibitor | |
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QC09AA07 | |
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No | |
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460.96 | |
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2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid;hydrochloride | |
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S-(R*,R*))-1H-1-benzazepine-1-acetic acid,3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-monohydrochloride | |
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Off-white crystalline solid | |
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Formulations |
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Benazecare Flavour 20 mg Tablets for Dogs | Ecuphar NV | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Fortekor 2.5 mg tablets for cats and dogs | Elanco Europe Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Arixil Vet Tablets | Industrial Veterinaria S.A. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually supplied in tablet form for oral administration |
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34000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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189 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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691 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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372 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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6.76 X 10-01 | Calculated | - | |||||||
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-0.17 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
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benazeprilat Note: Pharmacologically active |
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Terrestrial ecotoxicology |
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> 5000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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> 100 | E3 E = Manufacturers safety data sheets Danio rerio3 = Unverified data of known source |
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> 1000 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
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General |
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High (class III) | - | - | ||||||||
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> 5000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Metabolised in the liver to the active substance Benazeprilat. Equally excreted by both liver and kidney. Also excreted in breast milk and unmetabolized in faeces. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause diarrhoea, hypotension; disturbances in heart rhythm |
Handling issues |
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Incompatible with oxidising agents Emits toxic fumes in a fire |
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Not listed (Not listed) | |||
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benazepril hydrochloride | ||
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Record last updated: | 25/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |