Frusemide |
Last updated: 06/03/2024 |
(Also known as: furosemide) |
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A sulfonamide compound used as a diuretic in veterinary medicine | |
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circa 1970, introduced | |
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Used for the treatment of congestive heart failure, pulmonary edema, kidney disease, high blood pressure and edema in a range of animals | |
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Horses; Cats; Dogs; Cattle |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₂H₁₁ClN₂O₅S | |
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C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl | |
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No data | |
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ZZUFCTLCJUWOSV-UHFFFAOYSA-N | |
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InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) | |
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Yes |
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Common Name | Relationship | Link |
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frusemide | - |
General status |
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Diuretic, Antihypertensive | |
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Sulfonamide | |
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Synthetic | |
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Blocks the absorption of salt and fluid in the kidney tubules, causing diuresis. | |
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[Solute carrier family 12 member 1, Blocker] | |
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54-31-9 | |
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200-203-6 | |
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Cardiovascular system: Diuretics | |
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QC03CA01 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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330.75 | |
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4-chloro-2-(furan-2-ylmethylamino)- 5-sulfamoylbenzoic acid | |
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2-furfurylamino-4-chloro-5-sulfamoylbenzoic acid | |
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Pale yellow powder |
Formulations |
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Frusecare 40 mg Tablets | Dechra Ltd | Not licensed | Not licensed | ||||||
Frusecare oral 40 mg Tablets | Dechra Ltd | Not licensed | Not licensed | |||||||
Troy Furosemide Injection | Troy Laboratories Pty Ltd | Not licensed | Not licensed | |||||||
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73.1 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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295 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.07 X 1002 | Calculated | - | |||||||
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2.03 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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4.30 X 10-05 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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In ethanol: 288nm, 276nm, 336nm In NaOH: 226nm, 273nm, 336nm |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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4-chloro-5-sulfamoylanthranilic acid Note: Minor metabolite |
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Terrestrial ecotoxicology |
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> 2600 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 2600 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ = 4600 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 800 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Excreted largely unchanged in the urine | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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kidney, liver, bladder, cardiovascular system toxicant |
Handling issues |
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Do not use water jets to fight fires, use dry chemical, foam or water spray | |||
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Not listed (Not listed) | |||
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frusemide | ||
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furosemida | ||
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furosemidu | ||
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Record last updated: | 06/03/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |