Triclabendazole (Ref: CGA 89317) |
Last updated: 26/04/2024 |
(Also known as: CGA 89317) |
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A benzimidazole anthelmintic used in veterinary medicine | |
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Current | |
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1980s, first introduced | |
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Used for the control of liver flukes, scabies causing mites, bloodsuck lice and fly larvae | |
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Cattle; Sheep; Goats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₁₄H₉Cl₃N₂OS | |
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CSC1=NC2=CC(=C(C=C2N1)Cl)OC3=C(C(=CC=C3)Cl)Cl | |
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No data | |
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NQPDXQQQCQDHHW-UHFFFAOYSA-N | |
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InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19) | |
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Yes |
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Common Name | Relationship | Link |
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triclabendazole | - |
General status |
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Anthelmintic, Antiparasitic Medicinal drug | |
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Benzimidazole | |
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>97% | |
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- | |
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Synthetic | |
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It binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis. | |
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[Microtubule formation, Inhibitor] | |
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68786-66-3 | |
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Antiparasitic products, insecticides & repellents: Anthelmintics | |
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QP52AC01 | |
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No | |
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Allowed substance (Table 1: Ruminants) | |
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359.66 | |
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- | |
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5-chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole | |
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6-chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole | |
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- | |
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- | |
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White to brown crystalline powder | |
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Formulations |
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Combinex Cattle Oral Suspension | Elanco Europe Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Cydectin Oral Suspension | Zoertis UK Ltd | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Triclafas Drench Oral Suspension | Norbrook Laboratories Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Usually available, often in combination with levamisole hydrochloride, as oral suspensions or as pour-on formulations |
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1.0 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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175 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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496 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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253.7 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.59 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.724 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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triclabendazole sulfone | - | Animal (Faeces) | - | ||||
4-hydroxy triclabendazole | - | Animal (Faeces) | - | ||||
2-benzimidazolone | - | Animal (Urine and Faeces) | - | ||||
triclabendazole sulfoxide | - | Animal (Faeces) | - |
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Terrestrial ecotoxicology |
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> 5000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Aquatic ecotoxicology |
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0.14 | E3 E = Manufacturers safety data sheets Oncorhynchus mykiss3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 5000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Low | ||||||||
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4000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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> 0.5 | E3 E = Manufacturers safety data sheets Rat 4 hr3 = Unverified data of known source |
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Mostly metabolised and excreted via urine and faeces. Also identified unchanged in breast milk. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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Possible liver and kidney toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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triclabendazole | ||
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triclabendazol | ||
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Record last updated: | 26/04/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |