Fusidic acid |
Last updated: 08/02/2024 |
(Also known as: diethanolamine fusidate) |
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A tetracyclic triterpenoid veterinary drug used as a bacteriostatic against gram-positive organisms | |
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Current | |
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1960s, first developed | |
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Used to treat skin infections such as those caused by Staphylococcus spp. bacteria including impetigo and infected dermatitis | |
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Cats; Dogs; Rabbits |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₃₁H₄₈O₆ | |
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CC1C2CCC3(C(C2(CCC1O)C)C(CC4C3(CC(C4=C(CCC=C(C)C)C(=O)O)OC(=O)C)C)O)C | |
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C[C@H]1[C@@H]2CC[C@]3([C@H]([C@]2(CC[C@H]1O)C)[C@@H](C[C@@H]\4[C@@]3(C[C@@H](/C4=C(/CCC=C(C)C)\C(=O)O)OC(=O)C)C)O)C | |
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IECPWNUMDGFDKC-MZJAQBGESA-N | |
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InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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fusidic acid | - |
General status |
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Antibiotic, Antibacterial, Antimicrobial | |
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Tetracyclic triterpenoid | |
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Synthetic | |
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Bacterial protein synthesis inhibitor via interfering with elongation factor G | |
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[Elongation factor G, Antagonist], [Chloramphenicol acetyltransferase, Antagonist], [Chloramphenicol acetyltransferase 3, Antagonist] | |
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6990-06-3 | |
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230-256-0 | |
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3000226 | |
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Dernmatologicals: Corticosteroids, dermatological preparations | |
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QD07CC01 | |
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No | |
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516.71 | |
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(2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid | |
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Solid |
Formulations |
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Betafuse Gel | Norbrook Laboratories Ltd | GB Natinal authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Fuselieve Gel | Norbrook Laboratories Ltd | GB Natinal authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually supplied as a gel for topical use |
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192.5 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Decomposes before boiling | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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250 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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5.62 X 1006 | Calculated | - | |||||||
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6.75 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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5.7 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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- | hydroxy fusidic acid | Human (Liver) | - | ||||
- | glucuronide fusidic acid | Human (Liver) | - | ||||
- | 3-keto fusidic acid | Human (Liver) | - |
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Terrestrial ecotoxicology |
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> 1500 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 1500 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
Moderate | ||||||||
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Intraperitoneal LD₅₀ = 165 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 1200 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Excreted almost entirely in the bile, mostly as inactive metabolites | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Possible liver toxicant May cause rash, nasal congestion, cough or eye irritation |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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fusidic acid | ||
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acide fusidique | ||
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acido fusidico | ||
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Record last updated: | 08/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |