Butorphanol |
Last updated: 12/01/2024 |
(Also known as: butorfanol) |
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A synthetic opiod used in veterinary medicine | |
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Current | |
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Most commonly used as a narcotic for pain relief. Also used to reverse the effects of opioids whilst still giving pain relief. | |
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Horses; Dogs; Cats; Ferrets; Raccoons; Some rodents |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₁H₂₉NO₂ | |
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C1CCC2(C3CC4=C(C2(C1)CCN3CC5CCC5)C=C(C=C4)O)O | |
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C1CC[C@]2([C@H]3CC4=C([C@]2(C1)CCN3CC5CCC5)C=C(C=C4)O)O | |
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IFKLAQQSCNILHL-QHAWAJNXSA-N | |
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InChI=1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1 | |
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Yes |
General status |
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Analgesic, Medicinal drug | |
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Benzylisoquinoline | |
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Synthetic | |
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Intracellular inhibition of adenylate cyclase distrupting normal behaviour of membrane calcium and potassium channels. | |
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[Kappa-type opioid receptor, Agonist], [Delta-type opioid receptor, agonist], [Mu-type opioid receptor, agonist] | |
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42408-82-2 | |
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255-808-8 | |
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Nervous system: Analgesics | |
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QN02AF01 | |
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No | |
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327.47 | |
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17-cyclobutylmethyl-morphinan-3,14-diol | |
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Controlled substance | |
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White crystalline solid |
Formulations |
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Alvegesic vet | VMD NV | GB National uthorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Dolorex 10mg/mL Solution for Injection for horse, dog and cat | Zoetis UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Torbugesic Solution for injection | Zoetis UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Torphasol Solution for Injection | aniMedica GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated as a solution for injection but may also be available in tablet form |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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> 17 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 17 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat3 = Unverified data of known source |
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Intraspinal TDLo = 0.035 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Women3 = Unverified data of known source |
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Extensively metabolised by the liver and elimination occurs by urine and faecal excretion. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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High doses may cause seizures, falling, salivation, constipation, and muscle twitching |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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butorphanol | ||
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butorfanol | ||
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Record last updated: | 12/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |