Praziquantel |
Last updated: 18/05/2024 |
(Also known as: biltricide; central praziquantel) |
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An animal anthelmintic effective against gastrointestinal parasites | |
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Current | |
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Used to control parasitic worms including tape worms and flukes | |
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Cats; Dogs; Fish |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric. The commercial preparation is a mixture of equal parts of levo and dextro-isomers. | |
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C₁₉H₂₄N₂O₂ | |
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C1CCC(CC1)C(=O)N2CC3C4=CC=CC=C4CCN3C(=O)C2 | |
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No data | |
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FSVJFNAIGNNGKK-UHFFFAOYSA-N | |
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InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2 | |
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Yes |
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Common Name | Relationship | Link |
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praziquantel | - | |
praziquantel | - |
General status |
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Antiparasitic, Anthelmintic | |
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Pyrazinaisoquinoline | |
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Synthetic | |
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Though to cause parasitic paralysis leading to death. Disrupts Ca2+ homeostasis in adult worms. | |
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[Schistosome Calcium (Ca 2+) Channel] | |
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55268-74-1 | |
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259-559-6 | |
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Antiparasitic products, insecticides & repellents: Anthelmintics | |
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QP52 AA51 | |
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No | |
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Allowed substance (Table 1: Ovine, Equidae) | |
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312.41 | |
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(RS)-2-(cyclohexanecarbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one | |
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2-cyclohexylcarbonyl-1,2,3,6,11b-hexahydropyrazino[2,1a]isoquinoline-4-one | |
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Yellow to tan coloured solid |
Formulations |
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Aderexa Chewable Tablets | Krka d.d. Novo Mesto | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Bob Martin Clear 3 in 1 Flavoured Wormer | Vetoquinol UK Ltd | UK National authorisation | Authorised veterinary medicine for general sale (AVM-GSL) | |||||||
Drontal Plus Flavour Tablets | Vetoquinol UK Ltd | UK National authorisation | Authorised veterinary medicine for general sale (AVM-GSL) | |||||||
Quantex Tablets | Vetoquinol UK Ltd | UK National authorisation | Authorised veterinary medicine for general sale (AVM-GSL) | |||||||
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Usually supplied in tablet form for oral administration |
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400 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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97000 | L3 L = Pesticide manuals and hard copy reference books / other sources Ethanol3 = Unverified data of known source |
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567000 | L3 L = Pesticide manuals and hard copy reference books / other sources Chloroform3 = Unverified data of known source |
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136 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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544 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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255 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.63 X 1002 | Calculated | - | |||||||
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2.42 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.22 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2840 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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> 12.2 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Clarias gariepinus4 = Verified data |
Moderate | ||||||||
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30.07 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 2840 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Intraperitoneal LD₅₀ = 586 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intramuscular LD₅₀ > 2000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Excreted mainly via the urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause abdominal pain or cramps Possible liver toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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praziquantel | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |