Sulphadoxine |
Last updated: 18/05/2024 |
(Also known as: sulfadoxine; sulphormethoxine; sulforthomidine) |
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A sulfonamide antibacterial drug to treat or prevent various infections in livestock | |
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Current | |
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1981, first approved for medical use USA | |
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Used to treat respiratory tract infections such as bovine pneumonia pasteurellosis | |
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Cattle; Horses; Pigs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₁₂H₁₄N₄O₄S | |
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COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N | |
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No data | |
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PJSFRIWCGOHTNF-UHFFFAOYSA-N | |
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InChI=1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16) | |
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Yes |
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Common Name | Relationship | Link |
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sulphadoxine | - |
General status |
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Medicinal drug, Antibacterial, Antiparasitic | |
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Sulfonamide | |
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Synthetic | |
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Helps inhibit the enzyme dihydropteroate synthetase which restricts folic acid production | |
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[Dihydropteroate synthetase], [Bifunctional dihydrofolate reductase-thymidylate synthase, Inhibitor] | |
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2447-57-6 | |
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219-504-9 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01EQ13 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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310.33 | |
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4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide | |
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4-sulfanilamido-5,6-dimethoxypyrimidine | |
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White or off-white crystalline powder |
Formulations |
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Bimotrim Co Injection Solution for Injection | Bimeda Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Usually supplied as a solution for injection |
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2700 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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192 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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523 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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5.01 X 1000 | Calculated | - | |||||||
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0.7 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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6.16 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.11 X 10-04 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 5200 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 5200 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ = 2900 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 2900 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Eliminated partly by metabolism and partly by excretion of the unchanged compounds in urine or faeces | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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May contribute towards hepatitis &/or pneumonitis Side effects may include nausea, vomiting, convulsions, excitation & anorexia |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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sulphadoxine | ||
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sulfadoxina | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |