Bromhexine hydrochloride |
Last updated: 18/05/2024 |
(Also known as: bisolvon hydrochloride; bromohexine hydrochloride) |
|
|
An antibiotic, used alone or in combination with antimicrobials for its mucolytic properties | |
---|---|---|
|
Current | |
|
1950s, developed; 1961, Patented | |
|
Used in the control of respiratory disease involving production of excessive tenacious mucus | |
|
Cats; Dogs; Cattle; Pigs; Sheep; Pigeons |
Approval status |
|
Approved | |
---|---|---|
|
- |
Chemical structure |
|
- | |
---|---|---|
|
C₁₄H₂₁Br₂ClN₂ | |
|
CN(CC1=CC(=CC(=C1N)Br)Br)C2CCCCC2.Cl | |
|
- | |
|
UCDKONUHZNTQPY-UHFFFAOYSA-N | |
|
InChI=1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H | |
|
Yes |
|
Common Name | Relationship | Link |
---|---|---|
bromhexine hydrochloride | - | |
bromhexine | Parent |
General status |
|
Medicinal drug, Antibiotic, Expectorant | |
---|---|---|
|
Unclassified substance | |
|
- | |
|
- | |
|
Synthetic | |
|
Acts on the mucus at the formative stages in the glands, within the mucus-secreting cells. | |
|
[Angiotensin-converting enzyme 2, Binder], [Transmembrane protease serine 2] | |
|
611-75-6 | |
|
210-280-8 | |
|
- | |
|
- | |
|
5702220 | |
|
Respiratory system: Cough and cold preparations | |
|
QR05CB02 | |
|
No | |
|
- | |
|
412.59 | |
|
- | |
|
2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride | |
|
N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)ammonium | |
|
- | |
|
- | |
|
White crystalline powder | |
|
Formulations |
|
|
|
|
|
||||||
---|---|---|---|---|---|---|---|---|---|---|
|
Bisolvon 10 mg/g oral powder | Boehringer Ingelheim Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Bromhex-Air Forte oral powder | Pharmanovo Veterinararneimittel GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Exflow10 powder for drinking water | Ceva Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
|
Often formulated as powders for adding to drinking water and feeds |
|
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
4.0 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Low | ||||||||
|
10.0 | Q2 Q = Miscellaneous data from online sources Ethanol2 = Unverified data of unknown source |
- | ||||||||
0.2 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Chloroform3 = Unverified data of known source |
- | |||||||||
|
235 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Decomposes3 = Unverified data of known source |
- | ||||||||
|
Decomposes on melting | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
- | ||||||||
|
235 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
- | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
- | |||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- |
Degradation |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
|
- |
Soil adsorption and mobility |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | ||||||||||
|
- | ||||||||||
|
- |
Fate indices |
|
|
|
|
||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
- | - | - | ||||||||||||||||||||||||||
|
|
- | - | - | |||||||||||||||||||||||||
|
- | - |
Known metabolites |
None
|
Terrestrial ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
> 6000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
|
|
- | - | - | |||||||
|
- | - | |||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
- | - | - | |||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
- | |||||||||||
|
- | - | - | ||||||||
- | |||||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - |
Aquatic ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - |
|
- | - | - |
|
General |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
High (class III) | - | - | ||||||||
|
> 6000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
Subcutaneous LD₅₀ > 14000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
- | ||||||||
Intraperitoneal LD₅₀ = 1680 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
- | |||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | |||||||||
|
- | ||||||||||
|
Rapidly absorbed from the gastrointestinal tract and metabolises in the liver, excreted as metabolites in the urine | Q4 Q = Miscellaneous data from online sources 4 = Verified data |
- |
Health issues |
|
|
||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Prolonged exposure to the substance can produce target organs damage May cause gastrointestinal disturbances |
Handling issues |
|
|
|||
---|---|---|---|---|
|
No information available | |||
|
- | |||
|
Not listed (Not listed) | |||
|
- | |||
|
- | |||
|
- |
|
|
|
||
---|---|---|---|
|
bromhexine hydrochloride | ||
|
- | ||
|
- | ||
|
- | ||
|
bromessina | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- |
Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |