Carprofen |
Last updated: 18/05/2024 |
(Not known by any other names) |
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A NSAID drug that is used in veterinary medicine | |
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Used as a supportive treatment for the relief of arthritis | |
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Dogs; Cats; Cattle |
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Approved | |
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Approved |
Chemical structure |
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C₁₅H₁₂CINO₂ | |
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CC(C1=CC2=C(C=C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O | |
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No data | |
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PUXBGTOOZJQSKH-UHFFFAOYSA-N | |
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InChI=1S/C15H12ClNO2/c1-8(15(18)19)9-2-4-11-12-7-10(16)3-5-13(12)17-14(11)6-9/h2-8,17H,1H3,(H,18,19) | |
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Common Name | Relationship | Link |
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carprofen | - |
General status |
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Anti-inflammatory, Medicinal drug | |
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Carbazole | |
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Synthetic | |
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Reduces inflammation by inhibiting the production of COX-2 and other sources of inflammatory prostaglandins | |
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[Prostaglandin G/H synthase 2, Antagonist], [Prostaglandin G/H synthase 1, Antagonist] | |
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53716-49-7 | |
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258-712-4 | |
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Musculo-skeletal system: Anti-inflammatory and antirheumatic products | |
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QM01AE91 | |
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Allowed substance (Table 1: Bovine, Equidae) | |
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273.72 | |
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(RS)-2-(6-chloro-9H-carbazol-2-yl)propanoic acid | |
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6-chloro-α-methyl-9H-carbazole-2-acetic acid | |
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White crystalline solid |
Formulations |
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Canidryl Tablets | Chanelle Pharmaceuticals Manufacturing Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Carprieve Tablets | Norbrook Laboratories Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Carporal Tablets | Le Vet Beheer B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Formulated in a variety of ways to suit application including solutions for injection and tablets for oral administration |
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197.5 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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6.17 X 1003 | Calculated | - | |||||||
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3.79 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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149 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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149 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Metabolised in the liver, 70-80% eliminated in the faeces and the remainder in urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible liver and kidney toxicant May cause nausea, gastro-intestinal pain and diarrhoea |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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carprofen | ||
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carprofene | ||
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carprofeno | ||
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carprofeno | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |