Cefalexin |
Last updated: 12/01/2024 |
(Also known as: cephalexin; ceporexin-E; cephanasten; cophalexin; CEX) |
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A broad spectrum antibiotic commonly used in veterinary medicine | |
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Current | |
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1967, introduced | |
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Used to treat bacterial infections of the skin, urinary tract, respiratory tract, bones and joints | |
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Dogs; Cats; Cattle; Pigs; Sheep |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₁₆H₁₇N₃O₄S | |
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CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=CC=C3)N)SC1)C(=O)O | |
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CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)SC1)C(=O)O | |
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ZAIPMKNFIOOWCQ-UEKVPHQBSA-N | |
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InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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Cephalexin hydrate | - |
General status |
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Antibiotic, Medicinal drug, Antibacterial, Antimicrobial | |
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Cephalosporin | |
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Semi-synthetic | |
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Interferes with the bacteria's cell wall formation, causing it to rupture, and killing the bacteria. | |
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[Penicillin-binding protein 3, Antagonist], [Penicillin-binding protein 2a, Antagonist], [Penicillin-binding protein 1b, Antagonist], [Penicillin-binding protein 2B, Antagonist], [Penicillin-binding protein 1A, Antagonist] | |
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15686-71-2 | |
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239-773-6 | |
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27447 | |
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Antiinfectants for systemic use: Antibacterials for intramammary use | |
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QJ51DA01 | |
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No | |
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Allowed substance (Table 1: Bovine) | |
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347.39 | |
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(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}- 3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene- 2-carboxylic acid | |
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7-(D-2-amino-2-phenylacetamido)-3-methyl-delta(sup 3)-cephem-4-carboxylic acid | |
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White crystalline powder |
Formulations |
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Cefabactin Tablets | Le Vet Beheer B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Cephacare flavour 50 mg tablets for cats and dogs | Eucphar NV | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Cephorium Film-coated Tablets | TVM UK Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Ceporex Suspension Injection Solution | MSD Animal Health UK | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated as standard tablets, film-coated and chewable tablets as well as powders and intramammary suspensions for injection |
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1790 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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197 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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727 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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394 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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4.47 X 1000 | Calculated | - | |||||||
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0.65 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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5.2 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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pKa(2) = 7.3 | |||||||||||
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4.31 X 10-10 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Max: 260nm = 7750 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 20000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 20000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Intraperitoneal LD₅₀ = 4000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Subcutaneous LD₅₀ > 6100 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Majority (~80-90%) is excreted unchanged in urine within 6 hours of administration, remainder lost in bile and faeces | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause diarrhoea, dizziness, headache, indigestion, joint pain, stomach pain and tiredness |
Handling issues |
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Hazardous combustion or decomposition products are produced in a fire | |||
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Not listed (Not listed) | |||
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cefalexin | ||
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cefalexine | ||
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cefalexina | ||
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Record last updated: | 12/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |